CCTV News:On the afternoon of December 13th, the State Council Joint Defense and Control Mechanism held a press conference. A reporter asked, some elderly people wanted to be vaccinated before, but they were assessed as inconsistent due to basic diseases and other reasons. Does this mean that they have not been vaccinated against COVID-19?

　　Wang Huaqing, chief expert of immunization program of China CDC, responded that if there is a serious allergic reaction after vaccination, this kind of vaccine can’t be vaccinated again in the future, and most other situations belong to a slow vaccination scenario. In the early stage, because of the basic diseases, we assessed that it was impossible to vaccinate, and most of this situation belonged to delayed inoculation.

　　He said that if this elderly person has a basic disease, he is in the early stage of attack, he is in a stable stage after a period of treatment, or he can’t be vaccinated because of special treatment. When the special treatment is over, these people can consider vaccination, especially in the current situation where the epidemic intensity is relatively large and there are many sources of infection, these people can be vaccinated again after re-evaluation and permission. The elderly should be well protected before they are vaccinated, and this kind of protection is also needed in the later period. If he enters the stable period of the disease and after the special treatment, it is recommended to vaccinate as soon as possible if he meets the conditions.

In order to thoroughly implement the important exposition of the Supreme Leader General Secretary on scientific and technological innovation and the spirit of the important instructions on the reform, innovation and development of the aviation industry, the leaders of the party group of China Aviation Industry Corporation put forward new requirements and made new arrangements for the scientific and technological innovation work of the group during the investigation of the subordinate units of the group. On the occasion of the eighth "National Day of Science and Technology Workers", China Aviation Industry Corporation focused on serving the front line of science and technology and launched a series of actions with the theme of "New Wisdom" to provide more convenient and efficient conditions for scientific and technological innovation for the majority of scientific and technological workers, and further stimulate their enthusiasm for self-reliance and self-reliance in aviation high-level science and technology.

1. Party leaders went deep into the front line to investigate scientific and technological innovation.

▲ The leaders of the group’s party group investigate scientific and technological innovation.

The party group of China Aviation Industry Corporation attaches great importance to scientific and technological innovation and always puts scientific and technological innovation at the core of the overall development. Recently, Zhou Xinmin, Party Secretary and Chairman of China Aviation Industry Corporation, and Hao Zhaoping, Deputy Party Secretary and General Manager, went to Jiangxi, Shanghai, Gansu and other places to carry out relevant research work and visit cutting-edge scientific and technological innovations. In order to further promote the construction of China Aviation Industry Corporation’s capability center and sharing center, new requirements are put forward for scientific and technological innovation: first, we must resolutely take the lead in the aviation industry as the "flower of modern industry and the crown of manufacturing industry" and give full play to the role of scientific and technological innovation; Second, we should cultivate and develop new quality productivity, strengthen the research on basic technology and applied technology, and improve the laboratory system with integrated group and full professional coverage; Third, we must continue to improve the product pedigree, accelerate the breakthrough of key core technologies, and promote high-level and stable development through innovative development.

2. The Group’s first green book on scientific and technological innovation was officially released.

After careful planning, we carefully sorted out the main scientific and technological innovation planning channels, scientific and technological awards, achievements transformation, standards and norms, innovation platforms, digital aviation and innovation activities in higher authorities and groups in recent years, and compiled the Green Book of Scientific and Technological Innovation of China Aviation Industry Corporation Limited (2024 Edition) to provide desk reference books and innovative inspiration sources for the majority of scientific and technological workers.

3. The first "Learn from others" activity of the Group was officially launched.

In order to stimulate the innovation potential of young aviation science and technology workers and promote the cooperation of scientific and technological innovation in various units, China Aviation Industry Corporation (AVIC) relies on the "Aviation Industry Innovation Port" to carry out the innovation activities of the Young Doctor Association of Scientific and Technological Innovation. Since the launch of the activity, 169 doctoral members have completed the talent storage, and 101 projects have been declared. More than 600 leaders and experts, including group leaders, academicians and chief experts, participated in the voting and selection, and the List of Projects to be Supported by Learning from Others has been formed, and the project implementation will be promoted as planned in the future.

4. The first phase of the Group’s "Qingyun Project" was officially launched.

In order to strengthen the national strategic strength of aviation science and technology, build a highland of scientific and technological talents in aviation industry in Beijing, and build a digital innovation headquarters base, with the strong cooperation of China Aviation Industry Corporation and Beijing Municipal Government, the A1 scientific research building of the first phase of "Qingyun Project" passed the acceptance and was officially put into use, which will provide a cohesive environment for the majority of aviation science and technology workers, give full play to the driving role of aviation science and technology innovation scenes, drive the development of cutting-edge, systematic and basic technologies, and strive to build a world-class scientific and technological innovation base camp with modern aviation characteristics.

5. The research and development of the group’s "Smart Navigation, Quality Improvement and Efficiency Enhancement" model was completed.

In order to promote the in-depth application of artificial intelligence in the aviation field and use intelligent tools to serve scientific and technological workers to carry out scientific and technological innovation activities, China Aviation Industry Corporation has launched a large model of "Intelligent Navigation, Improving Quality and Increasing Efficiency" to realize the functions of comprehensive understanding and analysis of massive information, human-computer natural language interaction, intelligent semantic retrieval and generation, intelligent assistance in scientific research management, etc., to improve the work efficiency of scientific and technological workers in many aspects such as policy inquiry, scientific research management and achievement declaration, and to empower and increase efficiency in scientific and technological innovation.

At the same time, many units of China Aviation Industry Corporation have carried out various thematic activities such as scientific and technological innovation achievements exhibition and scientific and technological competition in a strong atmosphere of scientific and technological innovation.

May 30th.

"National Day of Science and Technology Workers"

Pay tribute to every scientific and technological worker!

Iron powder must be seen.

Original title: "China Aviation Industry Corporation launched a series of actions on the theme of" new wisdom "for scientific and technological workers"

Read the original text

Artificial intelligence will set off a new round of industrial development mode. Revolutionary experts talk about where the development of "big model" and "new quality productivity" will go. Where does the power of "new quality productivity" come from? On the afternoon of December 2, 2023, during the international conference on "Understanding China" (Guangzhou), Zhang Shuwu, a special researcher at the School of Artificial Intelligence of Beijing University of Posts and Telecommunications and deputy head of the overall expert group in the field of modern service industry of the Ministry of Science and Technology, Lv Benfu, vice president of the China Innovation Association and professor of school of economics and management of the University of Chinese Academy of Sciences, Mi Lei, the founding partner of Zhongke Chuangxing, a researcher at Xi ‘an Institute of Optics and Mechanics of China Academy of Sciences and a proponent of the concept of "hard science and technology", attended the guest interview to discuss how artificial intelligence can accelerate the formation of new quality Talking about the big model: Next year, the big model will return to rationality and be more optimized in the competition. Zhang Shuwu: The big model will further promote the recognition and understanding of natural language and characters, and it is a development of the leap-forward transformation of artificial intelligence technology. Algorithm, computing power and data are the three core components of the development of artificial intelligence. In the future, the algorithm will be continuously optimized, and the algorithm and computing power are common problems. With the game of ability and resources, there will be some survival of the fittest, and the core of competition will be data. Zhang Shuwu’s artificial intelligence is still not divorced from perceptual intelligence, and it is an empirical rather than structuralist analysis method, so there are still many unexplained and uncontrollable. Because it is a method of probability statistics, many accurate places are still difficult to apply. At present, the "Hundred Models War" in China is actually a process of big waves scouring the sand.It is expected that it will gradually return to rationality in 2024. Next year, the big model may pay more attention to data optimization and industrial development based on scenarios and vertical fields, not necessarily pursuing "big", but more likely pursuing "fine", and the big model will be more optimized in the competition. Mi Lei: Our Angel Wheel invested in a big model company represented by Zhipu AI. At present, from the perspective of innovation, the resources of large-scale models in the United States are relatively concentrated. China’s problems, such as insufficient computing power and data concentration, need to be integrated urgently. Decentralization makes it difficult to focus on tackling key problems-to reduce ineffective low-level repeated investment. When investing, it mainly depends on who is really involved in the big model at an early stage, and has invested, accumulated technology and accumulated talents for a long time. Mi Lei Lv Benfu: At present, there are three types of big models: pedestal model, industry model and exclusive model. From the application point of view, I don’t think there will be too many bases for the landing of big models next year. The exclusive big model may have two key points-one is the privatization deployment of the exclusive big model, and the other is the digital staff. Lv Benfu talks about "new quality productivity": green and intelligent are important features. Lv Benfu: Understanding "new quality productivity" can be seen from two aspects: one is the new track, and the other is the innovation of the old track. The new track means that the content must be new and there must be future industries and strategic emerging industries; On the other hand, it is an upgrade of traditional industries. No matter the old track or the new track, it has the following important characteristics: first, greening, the use of energy efficiency, must be the most important way of new quality productivity; The second is intelligence.In the process of industrial production, through the intelligent analysis of big data, the demand is accurately refined and personalized. Therefore, the precision of minimalism is the biggest innovation to productivity. Zhang Shuwu: In the past 20 years, China’s economy has achieved rapid development. The future development of digital economy is not a continuation of the Internet economy, so we must find a model that can replace the previous high-value economic development. This requires the formation of "new quality productivity" and the formation of new industries and new values. As a tool, artificial intelligence can empower all walks of life and realize the transformation of production methods. Mi Lei: "New quality productivity" is a new direction put forward to unite the consensus of economic development. "New" refers to new technologies, which, on the one hand, bring more new models and industries, on the other hand, solve the efficiency problems or bottlenecks of traditional industries; "Quality" means high quality, and new technology will bring high quality development. Especially in the new round of scientific and technological revolution such as artificial intelligence, quantum computing and synthetic biology, it is very important to form a consensus that it is very important to reduce redundant capacity building and grasp and grasp the new direction of future industries in advance. Exclusive Dialogue with Zhang Shuwu: The reshaping of industrial development mode led by artificial intelligence is the key issue. On the morning of December 2, the international conference "Understanding China" (Guangzhou) officially opened. At the scene, the reporter interviewed Zhang Shuwu, a special researcher at the School of Artificial Intelligence of Beijing University of Posts and Telecommunications and deputy head of the overall expert group in the field of modern service industry of the Ministry of Science and Technology. He said that artificial intelligence is the core component of the digital economy and a "new quality productivity."An important part of. In the next 5-10 years, the reshaping of industrial development mode led by artificial intelligence is the most critical issue at present, which will surely set off a new revolution in industrial development mode. Reporter: At present, artificial intelligence has become an important driving force for the new round of industrial and technological revolution. How does the development of artificial intelligence and digital economy contribute China wisdom to the development of global digital economy? Zhang Shuwu: Artificial intelligence is the core component of the digital economy and the representative component of new quality productivity. Since last year, the leap-forward development of artificial intelligence technology represented by big model, AIGC and generative artificial intelligence has brought about qualitative changes in many industrial development modes. In the next 5-10 years, the reshaping of industrial development mode led by artificial intelligence is the most critical issue at present, which will surely set off a new revolution in industrial development mode. At present, the whole world is seizing the commanding heights of artificial intelligence. China’s advantage is the industrial economy, especially the Internet economy, which has developed well in recent years. Artificial intelligence technology is actually a combination of data and algorithms. Algorithms are relatively common, while data is more unique. Whoever owns data can form a new scene of artificial intelligence development. The future development is no longer a gradual process, but a rapid development process. Therefore, we should adapt to the law of the development of modern science and technology, dare to explore and seize opportunities, seize the initiative of development and the right to define science and technology, and use the resources of artificial intelligence data to form new values and new quality productivity. Reporter: At present, how can China accelerate the formation of "new quality productivity"? In this process,How does artificial intelligence effectively empower "new quality productivity"? Zhang Shuwu: China has experienced two stages: the upgrading of traditional manufacturing industry, the high-value economy of infrastructure and the high-efficiency economic prosperity of the Internet, and is now entering a new stage of high-quality development of the digital economy. In the previous stage, the high-value economy represented by real estate and the Internet economy formed a relatively balanced economic pattern. However, both economies need to be reshaped at present. In the future, the core driving force of the digital economy is a new high-value depression formed by new quality productivity led by major scientific and technological breakthroughs. We should explore the growth points of this industry. Artificial intelligence is the booster of industrialization. It turned out that agriculture, manufacturing and service industries were separated, and the new network economic environment gave birth to the development mode of industrial integration. In the future, advanced manufacturing must be an industry highly integrated with service. In the process of high-quality development, it is very important to be driven by Chinese excellent traditional culture and technology. Because it can form a new development power and a new future industry with the integration of culture, economy and manufacturing. Cultural scene is the source of the development of artificial intelligence. Whether it is large model or holographic technology, it first comes from cultural scenes such as consumption and entertainment. In the future, the integration of culture, science and technology, economy and manufacturing will be a pillar industry closest to reality. Reporter: What are Guangdong-Hong Kong-Macao Greater Bay Area’s own advantages in artificial intelligence and digital economy? How to cultivate and expand strategic emerging industries through these advantages?Zhang Shuwu: Guangdong-Hong Kong-Macao Greater Bay Area is the forefront of China’s economic development. The Pearl River Delta has many scientific and technological resources and emerging industries, and it is also a science and technology highland in China. At the same time, the state has also given many good policies to support the creation of a new highland for the development of Guangdong-Hong Kong-Macao Greater Bay Area’s cultural industry. In the future, there will be many breakthroughs in Guangdong-Hong Kong-Macao Greater Bay Area, which will integrate Chinese excellent traditional culture, new culture and industrial economy to form a new development pattern.

　　Recently, Jin Peng, a graduate of Anqing Normal University in 2012, reported that Zhao Jingchun, an associate professor at the School of Humanities and Media of zunyi normal University, had plagiarized his undergraduate thesis in the article "On the Criticality of Liu Zhenyun’s Officialdom Novels" published publicly in 2013.

　　"My graduation thesis is more than 10,000 words, which was written under the guidance of many teachers." Jin Peng said that the article published by the other party is exactly the same as his own paper, and even the title and secondary title have not been changed. "My paper has not been published, and it may have been leaked when it was transmitted between classmates."

　　Later, according to China Youth Daily, Zhao Jingchun admitted to plagiarizing the paper, and said that he was lucky enough to buy it from an intermediary for 3,000 yuan. After receiving the paper, he did not make any changes and directly transferred to Journal of zunyi normal University.

　　The school also set up an investigation team and found that Zhao Jingchun’s encroachment on other people’s academic achievements was true and the circumstances of academic misconduct were more serious. Luo Liangjin, director of the school’s propaganda department, told the Beijing News reporter that the school made a decision: dismissing Associate Professor Zhao Jingchun; Announce the withdrawal of the paper, and announce the cancellation in the newspaper; Terminate and cancel all kinds of scientific research projects undertaken by it, and cancel its project application qualification within two years.

　　Previously, this paper appeared on Zhao Jingchun’s list of higher education titles in 2013. A few months later, Zhao Jingchun was hired as an associate professor from a lecturer. Luo Liangjin explained that because this is an undergraduate graduation thesis, it was not published publicly, and it was really not available when the journal system was audited.

　　The Beijing News reporter found that there are many writing agencies for papers, and according to the other party’s academic qualifications, topics, publishing platforms and other "offers", some of them received 700 yuan in thousands of words. And many companies provide one-stop service for writing and sending.

　　In the sale of papers, many paper writing agencies claim that originality is guaranteed. In this regard, experts said that most papers produced by writing agencies are not original. Once found out, buyers will face relevant penalties, but it is difficult for agencies and individuals to hold them accountable.

　　■ Dialogue

　　Jin Peng, the original author of the exclusive dialogue paper of the Beijing News reporter:

　　Don’t kill the other person with a stick.

　　Beijing News: How do you want to check the 2012 papers online?

　　Jin Peng: On the morning of August 3rd, a colleague in the office said that he would publish a paper and asked me for advice. I casually searched online and found that both HowNet and Wanfang System had this article, and the signature was not mine. I immediately clicked in to check the contents and found almost the same.

　　Beijing News: How did you feel at that time?

　　Jin Peng: Very angry. Because I like writing very much at ordinary times, I saw that the article was stolen and wanted to know what was going on.

　　Beijing News: How to release the report information?

　　Jin Peng: I described the process of paper creation on my WeChat account. At that time, I really worked hard and cherished this achievement. I hope that in this way, the plagiarists will take the initiative to find me and give an explanation.

　　Beijing News: How was the paper leaked? Did you ever think about publishing it?

　　Jin Peng: At the time of graduation, some younger brothers and sisters wanted to learn from them, so I sent them the electronic version of my thesis, which may have leaked out and ended up in the hands of an intermediary.

　　I had planned to take the academic road before, but I didn’t pass the exam in English. At the end of April, I was busy looking for a job and taking various exams. I thought about publishing a paper, but I gave up considering that it was difficult for undergraduates to publish.

　　Beijing News: After the incident, how did the other party explain it?

　　Jin Peng: On August 6th, Mr. Zhao Jingchun called me twice. He sincerely apologized and admitted that it was his mistake. He told me that the agent said that this paper was originally created by someone in the agency. He thought that spending 3000 yuan was equivalent to buying someone else’s copyright, so he didn’t change it much and used it directly. I had no idea that this was an undergraduate thesis.

　　Beijing News: Recently, you issued a public notice saying that you will no longer be held accountable. I hope the school can handle it lightly?

　　Jin Peng: I know that he didn’t intentionally copy my works in full, and zunyi normal University has also set up an investigation team, and the social attention is very high. I think he has been punished as he should, so there is no need to go further.

　　In the past two days, I have seen the school’s punishment for Mr. Zhao, and there are many voices of public condemnation. I believe he has suffered a lot. I have checked his resume and know the hard work of doing academic work. He also mentioned to me that the academic pressure in the first half of 2013 was great, and all the papers submitted did not respond. He may be at the threshold of evaluating his professional title, hoping not to be killed with a stick, and he should be given a chance to correct it.

　　Beijing News: What do you think of the result of handling things?

　　Jin Peng: I think the school’s punishment is quite severe. If you search this article online in the future, it would be better to correct the signature in HowNet, Baidu Library and other places.

　　■ Depth

　　one

　　There is a paper writing agency that "receives 700 words"

　　Zhao Jingchun said that the paper was purchased from an intermediary for 3,000 yuan. Yesterday, the Beijing News reporter searched for "papers to write on behalf of others", and found many agencies to write on behalf of others, such as Star paper net, Worry-Free paper net, First paper net, etc., and the homepage of the website has a dialog box for writing consultation.

　　A staff member surnamed Yu of Star paper net said that it is 1,400 yuan to provide one-stop service for writing and distributing periodical papers. "The writers are all doctoral students in school, ensuring originality and quality."

　　The online consultant of 51 Worry-Free paper net provided a website, which was opened as a "demand sheet for writing on behalf of others", including the title of the paper, expected price, word requirements and many other contents. The other party suggested that after filling in according to the specific requirements, there will be a professional writing teacher to inform the required writing time and price by email.

　　On the homepage of Taobao, the Beijing News reporter typed in the word "paper", and on the right side of the page, a row of online stores marked with the words "high-end customization" and "writing articles for others" appeared.

　　Some businesses are obscure, and the product information of "Integrity Ghost Studio" is classified as "propaganda copy"; There are also businesses openly hawking, and the webpage of the "General Editorial Department of Regular Periodicals Call for Papers" is directly displayed as "Papers published with the title of evaluation. thesis title, a provincial-level national cn periodical, issued articles on medical education, economy and electricity (sic)".

　　Many businesses have said that there is no problem in writing papers. According to the other party’s educational background and topic, the price and completion time are also different.

　　Among the four institutions that were asked to write papers, the price of thousands of words ranged from 150 yuan to 700 yuan. According to the grades of academic journals published by buyers, the writers were divided into three categories: undergraduates, in-service masters, and university teachers. At the same time, they promised to be absolutely original, and later revised until they were published smoothly. In addition, some merchants also provide agency services, with agency prices ranging from 500 yuan to 1000 yuan.

　　2

　　"Market" is not included in the undergraduate thesis.

　　Xiong Bingqi, vice president of the 21st Century Education Research Institute, said that the existence of the industrial chain of ghostwriting papers first comes from the abnormal demand for papers. "China’s colleges and universities require papers for students’ study and for teachers’ assessment and rating."

　　Secondly, China’s universities regard the number of papers published as an important school achievement. When evaluating teachers and students, some schools only require the submission of titles and periodicals of published papers, and do not review the papers themselves at all. This has led some teachers and students who are eager for quick success and instant benefit to take "shortcuts".

　　In the sale of papers, many paper writing agencies claim to ensure the originality and quality of papers. In this regard, a university teacher who asked not to be named said that most of the papers produced by writing agencies are not original. Part of it comes from copying and piecing together, and the other part is to acquire unpublished papers. The acquisition channel may be to take over every link of the paper.

　　The thesis that Zhao Jingchun bought from the agency was finally identified as Jin Peng’s undergraduate thesis. And this paper even appeared on the list of its higher education title evaluation. The school said that because "undergraduate graduation thesis was not published publicly", the journal system could not be queried during the audit.

　　Xiong Bingqi said that at present, the papers of graduate students and doctoral students are uploaded through the academic journal network, but the graduation papers of undergraduates in almost all schools are not included in the academic journal network.

　　He analyzed that the reason may be that academic journals think that the quality of undergraduate papers is not high. But "this provides an opportunity for the paper writing agency. Many writing agencies buy unpublished undergraduate papers at low prices and then resell them to earn the difference. "

　　"Even if the purchased paper is successfully published, it does not mean that it is original." Xiong Bingqi reminded that writing agencies can make full use of the time difference of academic database retrieval to copy papers that have just been published or have passed the defense but have not been entered into the academic database. Such a paper will be exposed sooner or later, even if it escapes the examination of academic journals.

　　three

　　There are penalties for buying papers, and it is difficult for sellers to be held accountable.

　　The Ministry of Education’s Measures for Preventing and Handling Academic Misconduct in Colleges and Universities stipulates that "plagiarism, plagiarism, and embezzlement of other people’s academic achievements" should be regarded as academic misconduct; The Measures for Handling the Falsification of Dissertations also clearly stipulates that if the dissertations are purchased, written by others, plagiarized or forged data, their qualifications for degree application may be cancelled; If a degree has been obtained, the awarding unit may revoke its degree.

　　Zhao Jingchun’s plagiarism was identified as a serious academic misconduct, and he himself was dismissed as an associate professor. However, there are no penalties for the intermediary agencies that provide papers for them.

　　Ren Mengshan, an associate professor at China Communication University, mentioned that although colleges and universities have corresponding punishment measures for students and teachers who plagiarize papers, there is no relevant law in China that explicitly prohibits writing papers for institutions and individuals, and the regulation and management of this piece is still blank.

　　Xiong Bingqi also said that the original "commitment" of writing papers on behalf of others is not reliable. Once the buyer of the paper is exposed to plagiarism, he will be held accountable for academic misconduct, and the responsibility for plagiarism will also be borne by himself. In addition, it is difficult for him to investigate the responsibility of the writing agency for not speaking credit, because such behavior is illegal and not protected by law.

　　Director Liu Changsong of Mu Gong Law Firm believes that writing a thesis on behalf of others is equivalent to taking the test in the exam, and the nature of administrative punishment is the same. This practice undermines the academic affairs system and the examination system, and the competent department should stop and punish it according to the departmental regulations of the Ministry of Education.

　　This edition was written/Beijing News reporter Lei Zhao

　　　　　　　

　

　　　　A volunteer couldn’t bear to leave the giant panda and cried with the keeper.

　
Many citizens saw the giant panda off.

　
The staff carried the weighed panda onto a special transport vehicle.

　
After the quarantine, the panda gets bamboo shoots as a snack.

　　　　At 12: 45 yesterday, eight Olympic giant pandas who had lived in Beijing for nearly 10 months set foot on their journey back to Sichuan, and tens of thousands of tourists went to see them off. Volunteers who used to be commentators at the Olympic Panda Pavilion cried and said goodbye to the panda babies.

　　　　At about 11 o’clock last night, the giant pandas finally arrived at the Bifengxia base in Ya ‘an, China Conservation Giant Panda Research Center by plane and car. They are in good physical and mental condition and are sent to the animal house to rest.

　　　　　　82-year-old man came to see me off.

　　　　"Is the Olympic panda gone?" At 8 o’clock yesterday morning, hundreds of tourists gathered outside the giant panda hall of Beijing Zoo, all of whom were very concerned about the situation of giant pandas. The staff of the Panda Pavilion kept explaining that eight Olympic giant pandas were still on display as usual.

　　　　In the Olympic Panda Pavilion, eight giant pandas are playing or eating bamboo in their respective activity areas, enjoying themselves. Good sisters "Duoduo" and "Cuicui" snuggled up in the corner of the playground, "Huanhuan" and "Taotao" hugged and wrestled, and "Fuwa" lay on the ground with bamboo on all fours. Tourists took out their cameras and took photos with the little ones.

　　　　"I came here early in the morning just to see the giant panda for the last time." Grandma Wang, 82, lives in Fengtai District and took a bus to the zoo to bid farewell to the Olympic panda.

　　　　At 9 o’clock in the morning, on the stage on the west side of the Giant Panda Pavilion, more than 20 children from Yinhe Youth Art Troupe sang "Love is the Most Beautiful": "panda,panda, I love you …" The immature singing attracted many tourists’ attention.

　　　　At the short farewell ceremony held in Beijing Zoo, China Research Center for the Protection of Giant Panda presented Wolong soil and Minjiang River water to Beijing Park Management Center. A "national treasure map" with 13 panda cubs born after the earthquake and the palm print of the panda cubs were presented to Beijing Zoo, and the naming right of one of the cubs was given to Beijing. After collecting the names of cubs from the public, Beijing Zoo was finally named "Olympic Games".

　　　　Yang Changjiang, a breeder, said that in order to "lure" giant pandas into cages, they were only given half a breakfast. In the morning, the breeder has cleaned the Olympic Panda Pavilion and disinfected the cages for transporting giant pandas.

　　　　　The greedy cat "Meixin" was first caged.

　　　　In the morning, more than 10,000 people went to the zoo to bid farewell to the Olympic pandas. At 10 o’clock, after the Olympic Panda exhibition, many tourists gathered around the truck carrying the panda. Many children ride around their father’s neck, expecting the baby pandas to appear.

　　　　"Mei Xin, Guaibao, go home!" The breeder called "Meixin" who was playing outside the stadium in Sichuan dialect, and put the cage at the door of the animal house. Soon, "Meixin" got into the animal house, but "Fuwa" followed. The two little guys were attracted by carrots in the cage and blocked the cage door.

　　　　Li Feng, the breeder, waved a pot of carrots in front of Fuwa. Fuwa was attracted, only to find that the food outside the animal house could not be eaten, and immediately went to squeeze the door with Meixin. Seeing that there were more carrots in Li Feng’s hand than in the cage, the greedy cat "Meixin" stared intently at the food basin and followed the breeder to climb to the next animal house. The breeder patted Meixin’s nose, talked to her constantly, fed her, and calmed her mood. In about 5 minutes, "Meixin" was the first to be successfully "lured" into the cage.

　　　　At 11: 30 in the morning, the last baby panda was caged with fresh bamboo, apples and carrots.

Jingshang Sinotrans Zi [2022] No.32

Bureau of Commerce of each district, Bureau of Commerce and Finance of Development Zone, and relevant units:

　　According to the relevant provisions of the Notice of the Ministry of Finance and the Ministry of Commerce on Printing and Distributing the Measures for the Administration of Special Funds for Foreign Trade and Economic Development (Cai Jian [2022] No.3, hereinafter referred to as the Measures for Funds) and the Notice of the General Office of the Ministry of Finance and the General Office of the Ministry of Commerce on the Key Work of Special Funds for Foreign Trade and Economic Development in 2022 (Cai Ban Jian [2022] No.37), in order to do a good job in the declaration of import discount projects in 2022, we will now make relevant statements.

　　I. Basic information

　　The import discount is subject to catalog management, and this import discount declaration is based on the Catalogue of Technologies and Products Encouraged to Import (2016 Edition) issued by the National Development and Reform Commission, the Ministry of Finance and the Ministry of Commerce. The catalogue includes three parts: advanced technology encouraged to import, important equipment encouraged to import and key industries encouraged to develop. The Service Trade Department of our bureau is responsible for encouraging the introduction of advanced technology, and the Foreign Trade Operation Department is responsible for encouraging the import of important equipment and encouraging the development of key industries.

　　Second, the enterprise application conditions

　　(1) Import the products listed in the Catalogue of Technologies and Products Encouraged to Import (2016 Edition) issued by the National Development and Reform Commission, the Ministry of Finance and the Ministry of Commerce (hereinafter referred to as the Catalogue) and the new edition of the Catalogue issued according to the changes of the situation (excluding old products), or import the technologies listed in the Catalogue from non-affiliated enterprises.

　　(2) The applicant enterprise for imported products shall be the consuming and using unit on the Import Goods Declaration Form; The applicant for technology import shall be the technology user on the Registration Certificate of Technology Import Contract.

　　(3) The import declaration of imported products shall be completed from July 1, 2021 to June 30, 2022 (subject to the customs clearance date); The imported technology shall execute the contract from July 1, 2021 to June 30, 2022, and obtain the foreign exchange payment certificate issued by the bank.

　　(four) the technology import contract does not contain provisions that violate the regulations of People’s Republic of China (PRC) Municipality on the administration of technology import and export (the State Council DecreeNo. 331st).

　　(5) The equipment imported under "Key Industries to Encourage Development" in the Catalogue is not included in the Catalogue of Imported Commodities Not Exempted from Tax for Domestic Investment Projects (Adjusted in 2012) (Announcement No.83 of Ministry of Finance, National Development and Reform Commission, General Administration of Customs and State Taxation Administration of The People’s Republic of China, 2012).

　　(6) The total amount of imported products and technologies meeting the above conditions shall not be less than 500,000 US dollars.

　　(7) According to the relevant requirements, central enterprises in Beijing (all enterprises affiliated to central enterprises shall be declared through the Central Enterprise Group) shall be declared through their central departments (institutions), and the Beijing Municipal Bureau of Commerce will no longer accept them.

　　Third, the application materials

　　(1) Application documents signed by the legal representative of the enterprise (Annex 1), including: basic information of the enterprise, import purposes, expected benefits, project performance objectives (completion of work and objectives), etc.

　　(2) Notes on the Declaration of Import Discount Matters in 2022 (Annex 2) and electronic data.

　　(3) Business license of the enterprise (photocopy).

　　(4) Application Form for Import Discount Matters in 2022 (Annex 3) and electronic data.

　　(5) Import product order contract or technology import contract (photocopy, Chinese translation is required for non-Chinese contracts).

　　(six) imported products, the need to provide the "People’s Republic of China (PRC) Customs Import Goods Declaration Form" (copy or printed copy of the enterprise retained).

　　(7) If technology is imported, it is required to provide the Registration Certificate of Technology Import Contract, Data Sheet of Technology Import Contract and the foreign exchange payment certificate (photocopy) issued by the bank indicating the technology import contract number. If the technology user is inconsistent with the foreign exchange payment unit, the agency contract of both parties shall be provided. The amount of technology import refers to the amount of technology fees paid for importing technologies in the Catalogue from non-affiliated enterprises through transfer, licensing, commissioned development, cooperative development, technical consultation, etc. (excluding equipment, training, debugging, travel and other expenses, excluding technology import fees paid in proportion based on annual sales and profits). Please indicate the technology import contract number, technology name and the amount of foreign exchange payment that meets the discount conditions on the payment voucher.

　　(8) To import the equipment under "key industries to encourage development", it is necessary to provide the Confirmation of Domestic and Foreign-funded Projects Encouraged by the State (or the Confirmation Notice of Applicable Encouraged Industrial Policies issued by the Customs, including the list and photocopy of imported equipment attached to the confirmation letter or notice), the Certificate of Tax Exemption for Import and Export Goods (photocopy) and the Import Goods Declaration Form (photocopy). If the tax exemption certificate cannot be obtained because the tariff is zero, the tax exemption certificate may not be submitted, but the relevant situation shall be explained in the application report, and the certification materials that the relevant goods are zero tariff shall be submitted; Belonging to the "National Engineering (Technology) Research Center, National Engineering Laboratory, State-recognized Enterprise Technology Center, Key Laboratory, High-tech Entrepreneurship Service Center, New Product Development and Design Center, Scientific Research Pilot Base and Experimental Base Construction" in the third part of the Catalogue, it is not necessary to submit the Confirmation of Domestic and Foreign Projects Encouraged by the State, but it must be submitted to the Ministry of Science and Technology, the National Development and Reform Commission and other departments.

　　(nine) if the important equipment has technical parameters, it is necessary to provide import contracts or product manuals and other relevant certification materials that list the technical parameters of the goods.

　　(ten) the introduction of technology should explain whether it is introduced from affiliated enterprises, and the relevant information should be explained with supporting materials if the enterprise is renamed.

　　The above materials must be stamped with the official seal of the enterprise.

　　Iv. Work progress and reporting time

　　(1) Submit written materials on site from July 25th to July 29th, 2022 (in duplicate).

　　(2) Check the original materials on site from August 8 to August 12, 2022, and submit the bound paper materials (with page numbers) in triplicate and electronic data (submitted by USB flash drive).

　　V. Place and method of submitting materials

　　Venue: The application materials shall be delivered to the conference room on the second floor of Annex 6, Xili South District, Chaoyang Park, Chaoyang District, Beijing.

　　Method: In order to do a good job in epidemic prevention and control and avoid the possible infection risk caused by crowd gathering, this year’s import discount materials are submitted by appointment system. The reporting enterprise shall complete the telephone appointment from July 20th to July 22nd (9:00-18:00), submit the written materials at the site according to the agreed time, and will not accept the appointment afterwards. Each unit shall send at most one person to the site to declare the materials. Please leave the name and mobile phone number of the person when making an appointment.

　　Appointment telephone number for submission of materials: 17610520360

　　Business consultation telephone (product): 55579519

　　Business consultation telephone number (technology): 55579493

　　VI. Training and other arrangements

　　In order to do a good job in the declaration of import discount projects in 2022, the Municipal Bureau of Commerce is scheduled to hold a training meeting on the project declaration process from 15: 00 to 16: 30 on Monday, July 18, and enterprises that intend to declare can voluntarily participate. The training adopts online conference (Tencent conference number: 823614617), and participating enterprises need to download the "Tencent Conference" client in advance.

　　In order to facilitate communication and receive notification information, enterprises applying for intention can scan the QR code (Annex 4) and join the "Beijing 2022 Import Discount Declaration" WeChat group. Please note "enterprise name+contact person name" for enterprises joining the group.

　　I hereby inform you.

Beijing Municipal Bureau of Commerce　　　　

July 13th, 2022　　

　　Deeply understand and accelerate the development of new quality productive forces

　　Commentator of Qiushi magazine

　　"Developing new-quality productive forces is an inherent requirement and an important focus for promoting high-quality development. We must continue to do a good job in innovation and promote the accelerated development of new-quality productive forces."

　　On January 31, 2024, General Secretary of the Supreme Leader delivered an important speech when he presided over the 11th collective study in the Political Bureau of the Central Committee, systematically expounded the scientific connotation of new quality productivity from the combination of theory and practice, profoundly pointed out the great significance of developing new quality productivity, and put forward clear requirements for developing new quality productivity. From putting forward "new quality productive forces" during a local inspection in 2023, to emphasizing "developing new quality productive forces" at the Central Economic Work Conference, and then making a systematic exposition during the collective study of the Politburo, the General Secretary’s series of important expositions and major arrangements on developing new quality productive forces have profoundly answered the important theoretical and practical questions of "what is new quality productive forces, why should we develop new quality productive forces, and how to develop new quality productive forces", which provides a basis for promoting high-quality development in the new journey.

　　High-quality development needs the guidance of new productivity theory.

　　Marxism holds that productivity is the material premise of all social life, the most active and revolutionary factor to promote social progress, and the productivity standard is a fundamental standard to measure social development. Marx and Engels pointed out that "the sum of people’s productive forces determines the social situation". Unswervingly promoting the development of productive forces and constantly improving people’s living standards on this basis is the fundamental starting point of all our party’s work.

　　The fundamental task of socialism is to liberate and develop social productive forces, and the superiority of socialism over capitalism lies in its ability to develop productive forces faster and better. After the founding of New China, Comrade Mao Zedong proposed that "the purpose of socialist revolution is to liberate productive forces". After the reform and opening up, Comrade Deng Xiaoping clearly pointed out that "there are many tasks of socialism, but the fundamental one is to develop productive forces". Since the founding of the People’s Republic of China, our Party has only spent several decades leading the people to complete the industrialization process that developed countries have gone through for hundreds of years, promoting China’s development into the second largest economy in the world, and creating a miracle of rapid economic development that is rare in the world. It is extremely important to attach great importance to productivity standards, always adhere to the liberation and development of social productivity, and constantly enhance the comprehensive national strength of socialist countries.

　　Entering a new era, China’s economic development has entered a new stage. The CPC Central Committee with the Supreme Leader as the core regards adhering to high-quality development as the last word in the new era, consistently liberates and develops social productive forces, makes a series of major decisions and arrangements, and pushes China’s economy to a higher-quality, more efficient, fairer, more sustainable and safer development path. The level of productive forces has achieved great improvement and breakthrough development, forming a new qualitative state of productive forces development. In view of this new situation, the General Secretary of the Supreme Leader clearly pointed out that "the new quality productivity has been formed in practice and has shown a strong driving force and support for high-quality development".

　　At the same time, we should also see that there are still a lot of factors restricting high-quality development, such as some key core technologies being controlled by people, the problems of "big but not strong" and "all but not excellent" in the industry, and the pressure of transforming the production and living system to green and low carbon, and so on. To further promote high-quality development, we must form new industries, new models and new kinetic energy, firmly grasp key core technologies in our own hands, build a modern industrial system that is self-controllable, safe, reliable and competitive, build a green and low-carbon circular economy system, and realize connotative growth driven by innovation. In the final analysis, it is to achieve greater breakthroughs and greater development at the level of productivity. This puts forward a new topic for our theoretical development, and we need to further deepen our understanding of the new quality productivity. General Secretary of the Supreme Leader emphasized that the development of new quality productive forces "requires us to summarize and generalize theoretically to guide new development practice". General Secretary Supreme Leader’s important exposition on developing new-quality productive forces points out the important focus of promoting high-quality development, embodies a profound grasp of the development law of productive forces and the outstanding problems facing China’s development, and is a profound summary of the law of China’s economic construction, further innovating and developing Marxist productive forces theory, which is an important part of Supreme Leader’s economic thought and has important theoretical and practical significance. We must study deeply and deeply understand it and use it to guide practice.

　　Grasping the scientific connotation of new quality productivity

　　What is new quality productivity? General Secretary of the Supreme Leader pointed out: "In a nutshell, the new quality productivity is an advanced productivity that plays a leading role in innovation, gets rid of the traditional economic growth mode and productivity development path, has the characteristics of high technology, high efficiency and high quality, and conforms to the new development concept. It was born out of revolutionary breakthrough in technology, innovative allocation of production factors, and deep transformation and upgrading of industries. The basic connotation is the leap of laborers, labor materials, labor objects and their optimized combinations, and the core symbol is the substantial improvement of total factor productivity. Its characteristics are innovation, the key is high quality, and the essence is advanced productivity. " This important exposition profoundly points out the basic theoretical issues such as the characteristics, basic connotations, core symbols, characteristics, keys and essence of the new-quality productive forces, and provides a fundamental basis for us to accurately grasp the scientific connotation of the new-quality productive forces.

　　New-quality productivity is an advanced productivity with innovation as the leading role, and its characteristic is innovation. The key to grasping the new quality productivity lies in a deep understanding of the key role of innovation in improving productivity. Looking back at history, from the mechanization of the first industrial revolution in the 18th century to the electrification of the second industrial revolution in the 19th century, and then to the informationization of the third industrial revolution in the 20th century, subversive scientific and technological innovations have brought about great liberation of social productive forces and great leap in living standards, which fundamentally changed the development track of human history. Some countries have seized the rare opportunity of scientific and technological revolution and industrial transformation, and their comprehensive national strength has increased rapidly, even becoming a world power. At present, a new round of scientific and technological revolution and industrial transformation is ready to go, and some major disruptive technological innovations are creating new industries and new formats. Information technology, biotechnology, manufacturing technology, new material technology and new energy technology have penetrated into almost all fields, which has led to major group technological changes characterized by green, intelligence and ubiquity. We have ushered in the historic intersection of the new round of scientific and technological revolution and industrial transformation in the world and the transformation of development mode in China, and are faced with a once-in-a-lifetime historical opportunity. New quality productive forces have emerged as the times require and have continued to grow and develop in practice. New quality productivity represents the new direction and trend of scientific and technological revolution and industrial transformation, and represents the development direction of advanced productivity. To accelerate the formation of new quality productive forces is to gain a leading position in the development of productive forces, take the lead in new fields and new tracks, and win the initiative in development in fierce international competition.

　　Marx pointed out that "productivity, that is, the development of production capacity and its elements" and "labor productivity is developing with the continuous progress of science and technology". New quality productivity is the product of productivity development and scientific and technological progress, and it is a revolutionary promotion of human ability to transform nature. This promotion is holistic and fundamental, and as its constituent elements, workers, labor materials and labor objects must also have new connotations. As far as workers are concerned, workers are the most active factor in productivity. What matches the new quality productivity is no longer ordinary workers who focus on simple repetitive work, but strategic talents who can create new quality productivity and applied talents who can master new quality production materials skillfully. As far as labor materials are concerned, as a "measuring instrument for the development of human labor force", with the development and wide application of original technology and subversive technology, more and more new production tools will be produced, and old and backward production tools will be gradually replaced by new and advanced production tools, which is also the main symbol of the development of productive forces. As far as the object of labor is concerned, the improvement and extensive use of labor materials will inevitably lead to the expansion of the scope of labor objects, including not only traditional natural materials, but also intangible forms such as data that are not limited by space and time.

　　Only by combining various factors of production can we form realistic productive forces. New quality productivity is not only reflected in the innovative development of various factors, but also in the innovative development of the combination of production factors. With the development and changes of laborers, labor materials and labor objects in the new quality productivity, the optimized combination of the three will also undergo revolutionary changes, bringing new industries, new formats and new models, and forming new kinetic energy and new advantages that drive economic development. Productivity determines production relations, and production relations react on productivity. The formation of new quality productive forces will inevitably lead to revolutionary changes in production relations, and it is necessary to form new production relations to adapt to them, and protect, liberate and develop them. Constantly reforming and perfecting the relations of production and forming new management modes and new institutional mechanisms are important guarantees for promoting the continuous development of new quality productive forces.

　　In a word, we should deeply realize that the new quality productivity is not the local optimization and simple iteration of the traditional productivity, but the advanced productivity, which is spawned by the revolutionary breakthrough of technology, the innovative allocation of production factors and the deep transformation and upgrading of industries. It will certainly bring about changes in the development mode and production mode, promote the new leap of China’s social productivity and lay a more solid material and technological foundation for building a socialist modern country in an all-round way.

　　Promote new quality productivity and accelerate development.

　　"We can’t fall behind on the new track", "We should catch up, strive to achieve, run and even lead". At the Central Economic Work Conference in 2023, the words of the Supreme Leader General Secretary were inspiring. On the new journey of building a strong country and national rejuvenation, the most fundamental thing to promote Chinese modernization is to realize the modernization of productive forces. The essence of new quality productivity is advanced productivity. It is necessary to unify thoughts and actions with the spirit of the important speech of the Supreme Leader General Secretary and the decision-making arrangements of the CPC Central Committee, focus on the central task of economic construction and the primary task of high-quality development, further enhance the consciousness and initiative of promoting the development of new-quality productive forces, and improve the practical skills of promoting the development of new-quality productive forces.

　　— — Accelerate scientific and technological innovation. Scientific and technological innovation can give birth to new industries, new models and new kinetic energy, which is the core element of developing new quality productivity. We must strengthen scientific and technological innovation, especially original and subversive scientific and technological innovation, accelerate the realization of high-level scientific and technological self-reliance, lay a solid battle for key core technologies, and cultivate new kinetic energy for developing new quality productive forces.

　　— — Accelerate industrial innovation. Industry is the carrier of productive forces, and scientific and technological achievements can only become social productive forces through industrialization. It is necessary to apply scientific and technological innovations to specific industries and industrial chains in a timely manner, transform and upgrade traditional industries, cultivate and expand emerging industries, lay out and build future industries, and improve the modern industrial system. Layout the industrial chain around the development of new quality productivity, improve the resilience and safety level of the industrial chain supply chain, and ensure that the industrial system is self-controllable, safe and reliable.

　　— — Accelerate the innovation of development mode. Green development is the background of high-quality development, and new quality productivity itself is green productivity. We must speed up the green transformation of development mode, firmly establish and practice Lucid waters and lush mountains are invaluable assets’s concept, unswervingly take the road of ecological priority and green development, and vigorously advocate a green and healthy lifestyle in the whole society.

　　— — Accelerate the innovation of system and mechanism. The relations of production must meet the requirements of the development of productive forces. To develop new quality productive forces, we must further deepen the reform in an all-round way and form a new type of production relationship that is suitable for it. It is necessary to deepen the reform of the economic system and the scientific and technological system, and strive to get through the blocking points that constrain the development of new quality productive forces. Expand high-level opening to the outside world and create a good international environment for the development of new quality productive forces.

　　— — Accelerate the innovation of talent work mechanism. Talent is the first resource, and the essence of innovation drive is talent drive. In the final analysis, the development of new quality productive forces depends on innovative talents. In accordance with the requirements of developing new quality productive forces, we should smooth the virtuous circle of education, science and technology and talents, and improve the working mechanism of talent training, introduction, use and rational flow. Improve the income distribution mechanism in which factors participate, and create a good atmosphere to encourage innovation and tolerate failure.

April 27th

Xiaomi ecological chain enterprise

Ningbo qingmei electrics technology co., ltd

"Intelligent Manufacturing Project of Millet Dishwasher"

Sign a contract to settle in Zhangjiagang High-tech Zone

The total investment of the project is 500 million yuan.

This cooperation will give full play to the advantages of both sides in the field of intelligent manufacturing and innovation ecology, inject strong kinetic energy into regional industrial upgrading, and create a new benchmark for the smart home appliance industry in the Yangtze River Delta.

Xiaomi Dishwasher Intelligent Manufacturing Project signed a contract to settle in Zhangjiagang.

Intelligent manufacturing project of Xiaomi dishwasher

The land area is about 35 mu.

The total construction area is about 60,000 square meters

Relying on the core technical advantages of Qingmei Electric in the field of smart dishwashers, the project combines the innovative resources of Xiaomi ecological chain and the industry accumulation of gold medal home, focuses on the integrated research and development of cabinets and electricity and the expansion of smart kitchen scenes, and is committed to building a digital factory integrating design, production and sales.

Effect drawing of intelligent manufacturing project of millet dishwasher.

According to reports, the project will mainly build

3 intelligent dishwasher production lines, injection molding workshop,

Sheet metal workshop, intelligent warehouse,

Digital national laboratory, etc.

The main products are desktop series, full-size embedded dishwasher series, full-size embedded dishwasher series and so on. It is planned to produce 500,000 intelligent dishwashers annually. After the project is put into production, it is estimated that the annual output value will be 800-100 million yuan.

Xiaomi intelligent dishwasher product map.

As the sole partner of Mijia Dishwasher’s new platform, Qingmei Electric Appliance is a national high-tech enterprise and the drafting unit of the national standard of "Performance Test Method for Household Electric Dishwashers", with nearly 200 technical patents for dishwashers in four years.

In 2023, Qingmei Electric signed a three-year strategic cooperation agreement with Xiaomi Communication Technology Co., Ltd., and reached a strategic cooperation R&D agreement with Jinpai Kitchen Cabinet Home Technology Co., Ltd. in the same year to jointly lay out digital smart kitchens and build an integrated product platform for cabinets and electricity. At present, the products of Qingmei Electric include a full range of dishwashers, a kitchen center with integrated cabinet and electricity, and other emerging kitchen appliances. Leading the industry in the core technologies of dishwashers, such as integration of consumption and storage, intelligent delivery of dishwashing liquid, washing and drying.

Except for the millet dishwasher

Recently, many intelligent manufacturing projects have settled in Suzhou.

In order to speed up the construction of modern production system

Cultivate and develop new quality productivity and help bring in new kinetic energy

On April 27th, Wuzhong Taihu New Town Investment Promotion Project was signed. Eight innovative projects with a total investment of 3.2 billion yuan were signed and settled in Wuzhong, covering emerging fields such as intelligent travel and home service robots.

The eight projects are the intelligent high-end scooter, the unbounded high-end electric motorcycle, the high-end new energy tram of Jiexing Technology, the high-end new energy tram of Yuechuan Tuojing, the lawn mowing robot, the surge future swimming pool robot, the atomic remodeling 3D printing equipment and the R&D center of the clean-bound cruise window cleaning robot. Two of them are headquarters projects and six are R&D and production center projects. After the project is put into production, it is estimated that the output value will exceed 15 billion and the number of R&D personnel will reach 20,000.

Recently, a new project of Yangcheng Digital Valley Project in Jinjihu Business District of Suzhou Industrial Park was signed and settled. Among them, Suzhou Chineydy Intelligent Manufacturing Co., Ltd. signed a contract to build a new Yuanshu workshop. Chineydy Intelligent, a leading enterprise of artificial intelligence, integrates R&D, design and manufacturing, takes excellent engineering design R&D and software algorithm R&D as the strategic direction, and is committed to providing process solutions for global partners. Up to now, Chineydy Intelligent has won about 40 patents for inventions and utility models. The contracted area exceeds 15,000 square meters, which indicates that the enterprise will start a new journey in the field of intelligent equipment R&D and manufacturing.

As an important carrier of strategic emerging industries in Yangcheng Digital Valley Area, the newly-built Yuanshu Workshop focuses on frontier fields such as 5G+ industrial Internet, integrated circuits, medical devices and new materials, and takes the deep integration of "intelligence+industry" as the core to create an industrial demonstration zone of "changing intelligence from digital to network". The entry of Chineydy Intelligent will further strengthen the key link of the newly-built Yuanshu Workshop in the intelligent equipment industry chain.

On April 18th, brukner, the world’s leading machine and system manufacturer, signed a cooperation agreement with Suzhou Industrial Park Management Committee, and will invest 100 million US dollars to build its Asia-Pacific headquarters base integrating high-end manufacturing, R&D innovation, sales settlement and supply chain procurement in the park.

Brukner Group is a global leader in film stretching technology and one of the largest manufacturers of packaging machinery and equipment systems, providing large-scale high-end packaging production equipment and solutions for food, medical, automobile and daily consumer goods industries for a long time. This signing, brukner Group invested 100 million US dollars to introduce high-end film biaxial stretching equipment and solutions in the park, and build a comprehensive headquarters base integrating high-end manufacturing, R&D innovation, sales settlement and supply chain procurement. In the future, this headquarters base will become an important strategic hub for brukner Group to expand the Asia-Pacific market.

Original title: "Another project of Xiaomi settled in Suzhou! 》

Read the original text

Percutaneous argon-helium knife treatment of liver cancer is one of the non-surgical treatment methods in recent years, which indicates that the treatment of liver cancer has entered a new stage of cryotherapy. Professor Yang Yongping, director of the Department of Hepatology and Medicine, Fifth Medical Center, General Hospital of Chinese People’s Liberation Army, shared the cryoablation treatment of liver cancer in the first multi-disciplinary cooperation forum of Anhui Province, and the platform of treating liver cancer with sincerity specially compiled the essence for readers.

Overview of liver cancer

In China, hepatocellular carcinoma (HCC) is the fifth largest malignant tumor and the second largest tumor-related death cause, with a five-year survival rate of only 14.2%. How to treat liver cancer scientifically and benefit the long-term survival of patients is an important clinical problem, and it is also the gold standard to measure the treatment level of medical units. In 2022, the updated guidelines for prognosis and treatment strategy of clinical liver cancer (BCLC) in Barcelona proposed that patients with HCC should be accurately evaluated individually. Doctors need to fully consider the scope and load of the tumor, the nutritional status and human performance of the patient, complications, age, etc., and formulate individualized treatment methods for the patient.

No matter what stage the patient is in, local ablation is an important treatment. At present, a variety of mature local ablation treatment techniques for liver cancer have been formed, including radiofrequency ablation, microwave ablation, cryoablation, irreversible electroporation (nano-knife) and so on.

Overview of cryoablation therapy

Cryoablation therapy has experienced a long development process. In 1800, James Arnott discovered that the mixture of ice and salt could delay the progress of breast cancer, uterine cancer and skin cancer. In 1950, liquid nitrogen and dry ice were used to treat different kinds of diseases, especially benign skin lesions. In 1961, Cooper and Le introduced the first automatic cryosurgical equipment, but it used liquid nitrogen as refrigerant, which had many complications and was only used in laparotomy. In the 1970s and 1980s, liquid nitrogen needle was used to treat prostate hypertrophy and prostate cancer, but the cryoablation technology was stagnant due to many complications. In the 1990s, intraoperative ultrasound monitoring of freezing process was used in surgery by scholars, and argon was studied as the refrigerant. In 1998, the third generation cryosurgery system (Argon-Helium cryosurgery system) came out in the United States, which used argon as the refrigerant and helium as the heat medium, bringing revolutionary progress to minimally invasive cryosurgery. In 2000, cryotherapy entered American medical insurance. In 2003, the World Congress of Targeted Cancer Therapy recommended cryoablation as the first choice for advanced lung cancer and liver cancer. In 2010, the standardized diagnosis and treatment of liver cancer promoted by the Health Planning Commission listed cryoablation as a local treatment for liver cancer. In 2016, after more than 10 years of unremitting efforts, Professor Yang Yongping’s team led the overall and comprehensive innovation and development of percutaneous cryoablation of liver cancer at home and abroad, changed the international prejudice on cryoablation of liver cancer, turned the small path into the big road, the irregular into the norm, and the unpopular into the hot spot.The technological innovation of cryoablation of liver cancer won the first prize of Beijing Science and Technology Progress Award. In 2018, 2019 and 2020, experts’ consensus on imaging-guided cryoablation for lung cancer, experts’ consensus on imaging-guided cryoablation for bone and soft tissue tumors, experts’ consensus on imaging-guided cryoablation for kidney cancer and experts’ consensus on imaging-guided cryoablation for liver cancer were released respectively. So far, NCCN, AASLD, APASL, EASL and other guidelines have recommended cryoablation for the treatment of primary liver cancer.

At present, the Department of Hepatology Medicine of the General Hospital of the Chinese People’s Liberation Army has become the largest medical center for treating liver tumors in the world last year, constantly exploring the innovation of cryoablation technology, adopting high-vacuum heat insulation technology, only destroying the tumor site without damaging the surgical path, and adopting multi-stage heat exchange technology, which makes the refrigerant utilization rate higher and the cooling rate faster, and it is easier to induce the frozen immune response of liver cancer patients, activate their own anti-tumor immunity and produce ectopic tumor inhibition.

Therapeutic mechanism and characteristics of cryoablation technology

The cryoablation area is composed of central coagulative necrosis area and peripheral tissue injury area with different degrees. The mechanism of rapid direct cell necrosis in the central area includes mechanical damage caused by ice crystal formation inside and outside the cell and osmotic damage caused by dehydration and rupture of the cell. Peripheral injury areas are mainly related to freezing-related secondary injuries, including hypoxia death of tumor tissue caused by blood embolism, apoptosis caused by reversible injury, and waterfall-like ectopic tumor suppression by stimulating immune regulation.

The characteristics of cryoablation technology include: ① clear treatment boundary, real-time monitoring under image, safe and reliable treatment; ② Treatment can stimulate human immunity and strengthen tumor treatment; ③ Physical therapy is non-toxic to human body, with extremely low side effects; ④ The treatment is painless, without general anesthesia and participation of anesthesiologists, and the treatment is convenient; ⑤ Not limited by the artificial pacemaker installed in the body; ⑥ Effective, suitable for lung cancer, liver cancer, kidney cancer, breast cancer, prostate cancer and other solid tumors.

In addition, ultrasound, CT, laparoscopy or intraoperative direct vision guidance can be used for cryoablation treatment, and the tumor position and the formation of ice hockey can be monitored in real time.

Current situation of percutaneous cryoablation of HCC

Before 2005, based on the previously reported clinical research results, there were many complications, such as bleeding, liver parenchyma frost crack, freezing shock, coagulation dysfunction and so on. International scholars were cautious about this technology. After 2005, percutaneous cryoablation for liver cancer has developed in China, especially with the publication of China’s continuous clinical summary and high-level evidence in the top international journal Hepatology. More and more clinical studies have confirmed that percutaneous cryoablation for liver cancer is safe and effective, and international scholars have a positive attitude.

Professor Yang Yongping’s team took the lead in conducting clinical research to determine the indications of liver cirrhosis-related HCC by percutaneous cryoablation. In this study, 1681 patients with liver cirrhosis-related HCC and 682 patients with advanced HCC were selected, and the indications and standards of complete cryoablation and selective cryoablation were established. It was proposed that the ablation volume of the target lesion should exceed 50% of the tumor volume or minimize the tumor load, relieve the symptoms caused by the tumor, improve the quality of life and prolong the survival time. The study also innovatively changed the percutaneous puncture to guide needle to locate the introduction of vascular sheath to solve the problem of bleeding after cryoablation, which has been cited by foreign counterparts for many times and suggested routine application.

Indications for complete cryoablation of liver cancer:

① The maximum diameter of a single tumor is less than 5 cm, or the number of tumors is less than 3, and the maximum diameter is less than 3 cm;

② Recurrence after surgical resection or other local treatment meets the conditions ①;

③ Child-Pugh A or B of liver function, bilirubin level ≤51.3μmol/L, or reaching this standard after medical treatment;

④ The blood coagulation function is good (prothrombin activity > 40%, platelet count > 30×109//L, using sheath hemostasis and packing system);

⑤ECOG PS ≤2；

⑥ Cirrhosis, including a history of chronic liver disease, with enlarged hepatic fissure/metacentric colon/esophageal varices/gastric varices/serrated liver surface, a history of upper gastrointestinal bleeding or ascites, and platelets < 100×109/L..

Indications for selective cryoablation of liver cancer:

① Single tumor with a maximum diameter of > 5cm or multiple tumors with a maximum diameter of > 3cm that cannot be surgically removed, regardless of whether there is tumor thrombus in portal vein;

② Child-Pugh A or B liver function classification, bilirubin level ≤51.3μmol/L or reaching the standard after medical treatment;

③ The blood coagulation function is good (prothrombin activity > 40%, platelet count > 30×109/L, using sheath hemostasis and packing system);

④QECOG PS ≤2；

⑤ Cirrhosis, including a history of chronic liver disease, with widened hepatic fissure/metacentric colon/esophageal varices/gastric varices/serrated liver surface, a history of upper gastrointestinal bleeding or ascites, and platelets < 100×109/L..

In addition, Professor Yang Yongping’s team innovatively established measures to prevent and treat complications of percutaneous cryoablation of hepatocellular carcinoma. In this study, 3321 patients were selected, and the measures of percutaneous cryoablation of liver cancer complications were established and verified (Table 1).

Table 1 Measures for Complications of Percutaneous Cryoablation of Liver Cancer

Moreover, the study has achieved encouraging clinical results, which increased the complete tumor ablation rate by 10.6%, reduced the local tumor recurrence rate by 30.3% in 5 years, and improved the 5-year survival rate by 16.6%.

Advantages of cryoablation in the treatment of hepatocellular carcinoma

Although cryoablation has distinct advantages over radiofrequency ablation (RFA), there is no RCT study in the past to directly compare the efficacy of ablation of liver cancer, especially the safety. Professor Yang Yongping’s team designed RCT study in five years to evaluate the efficacy and safety of percutaneous cryoablation and radiofrequency ablation of liver cancer. For the tumor, there were statistical differences in the local tumor progression rate between the two groups at 1, 2 and 3 years: 3%, 7% and 7% in the frozen group, respectively; The RF group was 9%, 11% and 11% respectively (P = 0.043). Subgroup analysis: For hepatocellular carcinoma with a diameter of > 3cm, cryoablation has a lower local tumor progression rate (cryoablation vs. RF: 7.7% vs. 18.2%, P=0.041). There was no statistical difference in the local tumor progression rate between 1-2cm (frozen vs. RF: 0% vs.2.4%, P=1.000) and 2.1-3.0cm (frozen vs. RF: 4.1%vs.7.1%, P=0.656). The results were published in Hepatology magazine and also in China.

Professor Yang Yongping’s team also confirmed that cryoablation of HCC can produce ectopic tumor inhibition, with the incidence of ectopic tumor inhibition of 6.3%, and the median survival time of patients with ectopic tumor inhibition was significantly prolonged. The mechanism is related to the down-regulation of PD-1/PD-L1 and regulatory T cells after ablation. In addition, argon-helium cryotherapy is effective for elderly HCC.

Unresolved problems in cryoablation of HCC

There are also many problems to be solved in the process of cryoablation for HCC in the future:

1. Does tumor cell ablation release specific tumor cell death signal?

2. How can freezing produce the best ratio of necrosis and apoptosis?

3. Are the cytokines released after freezing derived from tumor microenvironment or natural immune response, and what is their time sequence?

4. Will the functional essence and time sequence of antigen presenting cells that absorb necrotic tissue change after cryoablation?

5. What is the effect of cryoablation and absorption of necrotic tissue on the immunosuppressive function of the body? How to reduce the immunosuppression of the body?

Expert introduction

　

Professor Yang Yongping.

Chinese people’s liberation army general hospital No.5 medical center

Director, Department of Hepatology and Medicine, PLA General Hospital

Chief physician, professor, doctoral tutor

Silver Star of Science and Technology of the General Logistics Department, winner of special allowance of the State Council

Chairman of the Professional Committee of Liver Diseases of China Research Hospital Association

Director of China Hepatitis Foundation

Director of China Research Hospital Association

Vice Chairman of Liver Disease Professional Committee of Beijing Branch of Chinese Medical Association

Vice Chairman of Liver Disease Professional Committee of Beijing Society of Integrated Traditional Chinese and Western Medicine

Take the lead in the major special topics of the "Thirteenth Five-Year Plan and Twelfth Five-Year Plan" of the country, the key topics of the "Twelfth Five-Year Plan" of the army and the key topics of the Beijing Municipal Science and Technology Commission in integration of defense and civilian technologies; Won one national science and technology progress award, one first prize of Beijing science and technology progress award and six second prizes of military science and technology progress award.

Finishing/platform review/Professor Yang Yongping

This article is only for medical and health professionals to understand information, and does not represent the views of this platform. This information cannot replace professional medical guidance in any way, nor should it be regarded as medical advice. If the information is used for purposes other than understanding the information, the platform and the author shall not bear the relevant responsibilities.

　　CCTV News:According to the WeChat official account news released by Shanghai, the Shanghai Central Meteorological Observatory issued a blue rainstorm warning signal at 12: 30 on August 23rd, 2023: Due to the influence of strong precipitation clouds, it is predicted that there will be precipitation in parts of central and southern Shanghai with a cumulative rainfall of more than 50 mm in six hours before midnight today. Please pay attention to the prevention of urban waterlogging caused by heavy rainfall, and do a good job in drainage and waterlogging prevention in low-lying and flood-prone areas.

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