Special feature of 1905 film network Before the Double Eleven, domestic fans had entered the carnival mode.On October 29th, 2020, at the 20th National Cinema Domestic New Film Promotion Conference, more than 500 people gathered in Hengdian, Zhejiang, including 51 cinemas, over 50 film investment companies, distributors and production representatives. China Film, Huaxia, Bona, Wanda, Huayi and other upstream production companies have collectively promoted more than 100 outstanding domestic new films (including co-productions).

According to the information such as the promotion film list and the preparatory film list released by major film and television companies, it is accumulated that 262 new films will have or are expected to land in the cinema market in 2021. Among them, 242 films were made in China, accounting for 92.37% of the total, and 20 films were co-productions.

Movie Channel Merging Media, together with 1905 Movie Network and M Big Data, released the "2021 Cinema Foresight Report", and made a comprehensive inventory of 262 new films from the perspectives of film types, themes, IP and production companies.

What secrets will this report tell the audience behind the new film?

New films: plot, animation and comedy account for the largest proportion.

262 new films to be released, what state the progress bar is in, is one of the most concerned issues for the audience.

Judging from the current shooting progress, after rough statistics, there are 68 films in the preparatory stage, 112 films in the shooting and production stage, and 68 films have been completed and finalized. The proportion of new films in the shooting and production stage is the largest, reaching 42.75% of the whole.

Among the films that have been booked, at the 20th National Cinema Domestic New Film Promotion Conference, three relay films were booked for the Spring Festival in 2021, which pushed the market sentiment to a climax. The three films just correspond to animation, comedy and plot types respectively, which is highly consistent with the portrait data of the new film types to be released.

After counting the main elements of 262 new films to be shown, it can be found that the film list types cover 26 categories. Among them, the number of films with plot elements is 101, accounting for 22.1%, ranking first in the film genre. Animation and comedy genre films followed closely, reaching 47 and 45 respectively, accounting for 17.9% and 17.1% of the total.

The number of new animated films ranks second, which is closely related to the national craze caused by high-quality domestic animated films such as, and so on. The comedy film has always been one of the evergreen films in the world.

In the top ten genre films, except for the above three, the number of new films about action, suspense, love, fantasy and crime is above 30. In recent years, these types of films have not run away from many box office dark horses and have a certain audience base.

With more new films being produced and finalized, China audiences will have more choices on the big screen in 2021. For cinema managers, these new films also indicate that cinema revenue has a basic guarantee.

New trend: the main melody melody is in full bloom.　

In recent years, with the right climate and the right people, the main melody blockbuster has become the new favorite of the market.

,,, etc., organically integrated the theme of the times with commercial value, achieving a double harvest of box office and word of mouth. Facts have proved that the main melody blockbuster skillfully integrated with commercial elements is easier to be digested and absorbed by the audience.

Among the new films to be released in 2021, the theme film is still an important part worthy of attention. Among these films, there are not only the 100th anniversary of the founding of the Party, but also the theme of resisting US aggression and aiding Korea, as well as red classic films.

In addition to reviewing history, many main melody films follow the pace of the times, praising China spirit and carrying forward patriotic feelings. For example, Shenzhou, which is the theme of manned spaceflight, Doctor China, which tells the story of China people’s war and epidemic, and China Flight Tester, which tells the story of China’s "test hero" Li Zhonghua, etc.

There are more realistic works based on real people and story prototypes. For example, the economic investigation film adapted from the "Fox Hunting Action" of the Ministry of Public Security, the story about the Jedi rescue of the frontier armed police, and the theme of getting rid of poverty.

Since the summer file in 2018, after the upsurge of realistic works was started, the strong sense of substitution and resonance of such works are more likely to give birth to box office dark horses and are more favored by capital. In 2021, the realistic works in the mainland film market are still at the peak of creation.

The market value of classic IP is reflected in many ways, such as sequels, adaptations and remakes. Among the 262 new films to be released, such as "manslaughter 2", etc., or will form a domestic series of films. Detective Chinatown 3, which will be released in the Spring Festival in 2021, has become one of the most concerned films in the sequel.

In addition, The Order of the Gods, which is based on the explosive mobile game IP, and The Blade of Wandering, which is based on the novel IP of Ghost Blowing Lights, remake the classic "Loyal Dog Eight Men" and other films with the same name, and it has been or is expected to be scheduled for 2021. Mature market awareness and broad audience base are important reasons why classic IP is popular in the market.

And Ne Zha have successively become explosions, which not only proves that the level of China’s film industry keeps pace with the times, but also sets off the creation fever of similar films.

At the 2020 China Science Fiction Conference held in early November, a set of data showed that under the leadership of The Wandering Earth, the total box office of domestic science fiction films reached 7,140.5 million in 2019, an increase of 212% compared with 2018. In the future, domestic sci-fi films such as "The Trilogy of Outer Space" directed by Chen Sicheng, supervised by Ning Hao and directed by Zhang Xiaobei will attract much attention from the market.

After the national cinemas resumed work in an orderly manner, the Opinions on Promoting the Development of Science Fiction Films jointly issued by the State Film Bureau and the China Association for Science and Technology strengthened the system construction of science fiction film production and personnel training from the policy level.

In terms of animated films, the new films to be released in the future are both young and adult. The series "Bears haunt", the permanent guest of the Spring Festival file, is the best choice for parents and children to watch movies. Adult-oriented animation, such as Phoenix and Nezha 2, adapted from classic fairy tales, shoulders the heavy responsibility of creating more glories for domestic animation.

It is worth mentioning that many domestic documentaries in the film list have international vision and production standards, and have certain box office potential. Directed by Jia Zhangke, after the world premiere of the special screening unit of the 70th Berlin International Film Festival, the audience gained online reputation. The first BRICS documentary film "Young People Without Borders" led by director Lu Chuan and the first water resource documentary "Zero Water Day" are all worthy of attention.

New mode: New and old film and television companies explore more cooperation modes.

The film and television circle has always been a vanity fair, and the participation of capital is indispensable behind many new films.

According to the current public information, a number of film and television production agencies have participated in the production and distribution of many new works. China Film Group, Huayi Brothers, WANDA CINEMAS and Enlight Media have exposed more than 20 reserved films respectively. By participating in the statistics of the number of projects, it is not difficult to find that the traditional film and television companies in the head are still in the leading echelon, and the new Internet film companies have grown into the backbone.

WANDA CINEMAS and Huayi Brothers, as the "big brothers" in the industry, give full play to the advantages of resource integration, not only participate in the production of Spring Festival blockbusters such as Detective Chinatown 3 and The Order of the Gods, but also actively arrange online film and television services such as online movies and online dramas, and actively explore more production modes and revenue channels.

As representatives of Internet film companies, Alibaba Pictures, Cat’s Eye Film and Tencent Film have an average reserve of more than 15 films. In the past, the lack of master explosion movies has become a collective pain point for Internet film companies. Nowadays, with the resources and experience accumulated by deep participation in publicity and development, these companies are testing water more and more times.

In addition to the increasing number of master works, the types in the company’s film list are more and more diversified, and both commercial expression and author’s style are equally important, which has become one of the content characteristics of Internet film companies participating in film production. At the beginning of the announcement, these companies took advantage of big data and launched more new models.

There are more and more cases in which traditional film companies and Internet film companies strengthen cooperation and give full play to their respective advantages. For example, among the producers of 1921, Fox Hunting, and other films, there are both traditional and Internet studios. In addition, new cross-border forces, represented by POP MART cultural and creative companies, are increasingly appearing among new film investors.

In the creation of big-screen works, besides the blessing of capital, the participation of filmmakers is essential. Judging from the creative information of new films to be released in 2021, many heavyweight filmmakers are active in all aspects of film creation.

Among them, three directors, Ning Hao, Jia Zhangke and Wu Ershan, all participated in the creation of five films. Their identity, from director to producer to actor, can be described as omnipotent. The change of different identities can also see the help of mature directors for the younger generation.

Among these films to be released, M Big Data sorts out the ten works that are most expected by netizens. Among them, six films, such as Detective Chinatown 3, Japanese and Korean, have been booked for the Spring Festival in 2021.

Detective Chinatown 3 ranks first in the M-fever list of 8 works scheduled for the Spring Festival next year, followed by The Rescue and Boonie Bears:The Wild Life. According to previous market experience, Detective Chinatown 3, which has the highest popularity before the screening, will lead the box office competition for the Spring Festival. Whether this film can break the curse of "the front runner can’t be the total box office champion" is worthy of attention.

In the future, 262 new films will meet the audience one after another. The collective booking and release of these new films indicates that the China film market has recovered its former vitality and will create more glories.

Original clinical nutrition network

Author: Plain dust-free

Postdoctoral fellow, University of California San Diego Cancer Center. Nutritionist, food safety engineer

Washington University in St Louis, graduate student in public health, pre-medical doctor. Doctor of Public Health from Louisiana State University Health Sciences Center, and Delta Omega Doctoral Award, one of the highest honors of American public health graduates. "China Clinical Nutrition Network" signed a dietitian

His main research interests are smoking cessation, alcohol withdrawal and marijuana withdrawal, nutrition and chronic diseases, and cancer prevention and control.

The article was first published in big doctor magazine, and was revised by the author and then pushed again.

China Clinical Nutrition Network has been authorized to reprint

Nutrients are various substances needed by the human body, which support the growth, development and normal physiological functions of the human body. The nutrients needed by the human body can be roughly divided into seven categories. In the past, we used 15 issues to introduce the physiological functions, excess and deficiency, food sources and hot topics of seven nutrients in detail.

The following is a brief summary of them and a link to introduce each nutrient in detail (click the title to enter directly):

General introduction

The first issue:

(Image from WeChat public platform public photo gallery)

1. protein

An important component of the human body, used to repair and build body tissues, is also the main component of enzymes, hormones and antibodies. Protein is rich in meat, eggs, beans, nuts and seeds.

Phase II:

(Image from WeChat public platform public photo gallery)

2. Fat

Provide energy for the body and help absorb fat-soluble vitamins. It includes saturated fat, monounsaturated fat and polyunsaturated fat. Healthy sources of fat include fish, nuts, seeds and olive oil.

The third issue:

(Image from WeChat public platform public photo gallery)

3. carbohydrates

The main energy source of the human body. It includes sugar, starch and fiber. Whole grains, vegetables, fruits and beans are good sources of carbohydrates.

Phase IV: Phase V:

(Image from WeChat public platform public photo gallery)

4. vitamins

Nutrients that the human body cannot make by itself and must obtain from food or supplements. They contribute to various physiological functions of the body, including immunity, vision and bone health. Vitamins are mainly obtained by eating fresh vegetables, fruits and whole grains.

Issue 6: Issue 7: Issue 8:

(Image from WeChat public platform public photo gallery)

5. minerals

It is very important for bone health, muscle function, nerve conduction and some biochemical reactions. Foods rich in minerals such as fresh vegetables, fruits, whole grains, nuts and seeds.

Issue 9: Issue 10: Issue 11: Issue 12:

(Image from WeChat public platform public photo gallery)

6. Dietary fiber

Although they are not absorbed by human body, they have many health benefits, including improving digestion, preventing constipation, controlling blood sugar and reducing the risk of heart disease. Dietary fiber mainly comes from vegetables, fruits, whole grains and beans.

Issue 13:

(Image from WeChat public platform public photo gallery)

7. Water

The main component of the human body is vital to the functions of all body systems, including temperature regulation, waste removal and transportation of nutrients.

Issue 14: Issue 15:

(Source: WeChat public platform public photo library)

Attachment: Nutritional catering

Why do people eat so many kinds of food every day? Because the body needs balanced nutrients! Every food contains different nutrients, so we need to take them from different foods. Generally, weight catering method and energy catering method can be used.

Issue 16: Issue 17: In the next series, we will use 10 issues to introduce nutrition and health in different life cycles, including the potential impact of newborn birth weight on health, eating and sleeping of babies, health and nutrition needs of children and adolescents, and nutrition needs and health management in early, middle and late adulthood. Regarding the life cycle, if you have any special topics you want to know, please leave a message.

Original title: "[Popular Science Nutrition] A summary of the seven nutrients and nutritional meals that the human body needs! 》

Read the original text

Percutaneous argon-helium knife treatment of liver cancer is one of the non-surgical treatment methods in recent years, which indicates that the treatment of liver cancer has entered a new stage of cryotherapy. Professor Yang Yongping, director of the Department of Hepatology and Medicine, Fifth Medical Center, General Hospital of Chinese People’s Liberation Army, shared the cryoablation treatment of liver cancer in the first multi-disciplinary cooperation forum of Anhui Province, and the platform of treating liver cancer with sincerity specially compiled the essence for readers.

Overview of liver cancer

In China, hepatocellular carcinoma (HCC) is the fifth largest malignant tumor and the second largest tumor-related death cause, with a five-year survival rate of only 14.2%. How to treat liver cancer scientifically and benefit the long-term survival of patients is an important clinical problem, and it is also the gold standard to measure the treatment level of medical units. In 2022, the updated guidelines for prognosis and treatment strategy of clinical liver cancer (BCLC) in Barcelona proposed that patients with HCC should be accurately evaluated individually. Doctors need to fully consider the scope and load of the tumor, the nutritional status and human performance of the patient, complications, age, etc., and formulate individualized treatment methods for the patient.

No matter what stage the patient is in, local ablation is an important treatment. At present, a variety of mature local ablation treatment techniques for liver cancer have been formed, including radiofrequency ablation, microwave ablation, cryoablation, irreversible electroporation (nano-knife) and so on.

Overview of cryoablation therapy

Cryoablation therapy has experienced a long development process. In 1800, James Arnott discovered that the mixture of ice and salt could delay the progress of breast cancer, uterine cancer and skin cancer. In 1950, liquid nitrogen and dry ice were used to treat different kinds of diseases, especially benign skin lesions. In 1961, Cooper and Le introduced the first automatic cryosurgical equipment, but it used liquid nitrogen as refrigerant, which had many complications and was only used in laparotomy. In the 1970s and 1980s, liquid nitrogen needle was used to treat prostate hypertrophy and prostate cancer, but the cryoablation technology was stagnant due to many complications. In the 1990s, intraoperative ultrasound monitoring of freezing process was used in surgery by scholars, and argon was studied as the refrigerant. In 1998, the third generation cryosurgery system (Argon-Helium cryosurgery system) came out in the United States, which used argon as the refrigerant and helium as the heat medium, bringing revolutionary progress to minimally invasive cryosurgery. In 2000, cryotherapy entered American medical insurance. In 2003, the World Congress of Targeted Cancer Therapy recommended cryoablation as the first choice for advanced lung cancer and liver cancer. In 2010, the standardized diagnosis and treatment of liver cancer promoted by the Health Planning Commission listed cryoablation as a local treatment for liver cancer. In 2016, after more than 10 years of unremitting efforts, Professor Yang Yongping’s team led the overall and comprehensive innovation and development of percutaneous cryoablation of liver cancer at home and abroad, changed the international prejudice on cryoablation of liver cancer, turned the small path into the big road, the irregular into the norm, and the unpopular into the hot spot.The technological innovation of cryoablation of liver cancer won the first prize of Beijing Science and Technology Progress Award. In 2018, 2019 and 2020, experts’ consensus on imaging-guided cryoablation for lung cancer, experts’ consensus on imaging-guided cryoablation for bone and soft tissue tumors, experts’ consensus on imaging-guided cryoablation for kidney cancer and experts’ consensus on imaging-guided cryoablation for liver cancer were released respectively. So far, NCCN, AASLD, APASL, EASL and other guidelines have recommended cryoablation for the treatment of primary liver cancer.

At present, the Department of Hepatology Medicine of the General Hospital of the Chinese People’s Liberation Army has become the largest medical center for treating liver tumors in the world last year, constantly exploring the innovation of cryoablation technology, adopting high-vacuum heat insulation technology, only destroying the tumor site without damaging the surgical path, and adopting multi-stage heat exchange technology, which makes the refrigerant utilization rate higher and the cooling rate faster, and it is easier to induce the frozen immune response of liver cancer patients, activate their own anti-tumor immunity and produce ectopic tumor inhibition.

Therapeutic mechanism and characteristics of cryoablation technology

The cryoablation area is composed of central coagulative necrosis area and peripheral tissue injury area with different degrees. The mechanism of rapid direct cell necrosis in the central area includes mechanical damage caused by ice crystal formation inside and outside the cell and osmotic damage caused by dehydration and rupture of the cell. Peripheral injury areas are mainly related to freezing-related secondary injuries, including hypoxia death of tumor tissue caused by blood embolism, apoptosis caused by reversible injury, and waterfall-like ectopic tumor suppression by stimulating immune regulation.

The characteristics of cryoablation technology include: ① clear treatment boundary, real-time monitoring under image, safe and reliable treatment; ② Treatment can stimulate human immunity and strengthen tumor treatment; ③ Physical therapy is non-toxic to human body, with extremely low side effects; ④ The treatment is painless, without general anesthesia and participation of anesthesiologists, and the treatment is convenient; ⑤ Not limited by the artificial pacemaker installed in the body; ⑥ Effective, suitable for lung cancer, liver cancer, kidney cancer, breast cancer, prostate cancer and other solid tumors.

In addition, ultrasound, CT, laparoscopy or intraoperative direct vision guidance can be used for cryoablation treatment, and the tumor position and the formation of ice hockey can be monitored in real time.

Current situation of percutaneous cryoablation of HCC

Before 2005, based on the previously reported clinical research results, there were many complications, such as bleeding, liver parenchyma frost crack, freezing shock, coagulation dysfunction and so on. International scholars were cautious about this technology. After 2005, percutaneous cryoablation for liver cancer has developed in China, especially with the publication of China’s continuous clinical summary and high-level evidence in the top international journal Hepatology. More and more clinical studies have confirmed that percutaneous cryoablation for liver cancer is safe and effective, and international scholars have a positive attitude.

Professor Yang Yongping’s team took the lead in conducting clinical research to determine the indications of liver cirrhosis-related HCC by percutaneous cryoablation. In this study, 1681 patients with liver cirrhosis-related HCC and 682 patients with advanced HCC were selected, and the indications and standards of complete cryoablation and selective cryoablation were established. It was proposed that the ablation volume of the target lesion should exceed 50% of the tumor volume or minimize the tumor load, relieve the symptoms caused by the tumor, improve the quality of life and prolong the survival time. The study also innovatively changed the percutaneous puncture to guide needle to locate the introduction of vascular sheath to solve the problem of bleeding after cryoablation, which has been cited by foreign counterparts for many times and suggested routine application.

Indications for complete cryoablation of liver cancer:

① The maximum diameter of a single tumor is less than 5 cm, or the number of tumors is less than 3, and the maximum diameter is less than 3 cm;

② Recurrence after surgical resection or other local treatment meets the conditions ①;

③ Child-Pugh A or B of liver function, bilirubin level ≤51.3μmol/L, or reaching this standard after medical treatment;

④ The blood coagulation function is good (prothrombin activity > 40%, platelet count > 30×109//L, using sheath hemostasis and packing system);

⑤ECOG PS ≤2；

⑥ Cirrhosis, including a history of chronic liver disease, with enlarged hepatic fissure/metacentric colon/esophageal varices/gastric varices/serrated liver surface, a history of upper gastrointestinal bleeding or ascites, and platelets < 100×109/L..

Indications for selective cryoablation of liver cancer:

① Single tumor with a maximum diameter of > 5cm or multiple tumors with a maximum diameter of > 3cm that cannot be surgically removed, regardless of whether there is tumor thrombus in portal vein;

② Child-Pugh A or B liver function classification, bilirubin level ≤51.3μmol/L or reaching the standard after medical treatment;

③ The blood coagulation function is good (prothrombin activity > 40%, platelet count > 30×109/L, using sheath hemostasis and packing system);

④QECOG PS ≤2；

⑤ Cirrhosis, including a history of chronic liver disease, with widened hepatic fissure/metacentric colon/esophageal varices/gastric varices/serrated liver surface, a history of upper gastrointestinal bleeding or ascites, and platelets < 100×109/L..

In addition, Professor Yang Yongping’s team innovatively established measures to prevent and treat complications of percutaneous cryoablation of hepatocellular carcinoma. In this study, 3321 patients were selected, and the measures of percutaneous cryoablation of liver cancer complications were established and verified (Table 1).

Table 1 Measures for Complications of Percutaneous Cryoablation of Liver Cancer

Moreover, the study has achieved encouraging clinical results, which increased the complete tumor ablation rate by 10.6%, reduced the local tumor recurrence rate by 30.3% in 5 years, and improved the 5-year survival rate by 16.6%.

Advantages of cryoablation in the treatment of hepatocellular carcinoma

Although cryoablation has distinct advantages over radiofrequency ablation (RFA), there is no RCT study in the past to directly compare the efficacy of ablation of liver cancer, especially the safety. Professor Yang Yongping’s team designed RCT study in five years to evaluate the efficacy and safety of percutaneous cryoablation and radiofrequency ablation of liver cancer. For the tumor, there were statistical differences in the local tumor progression rate between the two groups at 1, 2 and 3 years: 3%, 7% and 7% in the frozen group, respectively; The RF group was 9%, 11% and 11% respectively (P = 0.043). Subgroup analysis: For hepatocellular carcinoma with a diameter of > 3cm, cryoablation has a lower local tumor progression rate (cryoablation vs. RF: 7.7% vs. 18.2%, P=0.041). There was no statistical difference in the local tumor progression rate between 1-2cm (frozen vs. RF: 0% vs.2.4%, P=1.000) and 2.1-3.0cm (frozen vs. RF: 4.1%vs.7.1%, P=0.656). The results were published in Hepatology magazine and also in China.

Professor Yang Yongping’s team also confirmed that cryoablation of HCC can produce ectopic tumor inhibition, with the incidence of ectopic tumor inhibition of 6.3%, and the median survival time of patients with ectopic tumor inhibition was significantly prolonged. The mechanism is related to the down-regulation of PD-1/PD-L1 and regulatory T cells after ablation. In addition, argon-helium cryotherapy is effective for elderly HCC.

Unresolved problems in cryoablation of HCC

There are also many problems to be solved in the process of cryoablation for HCC in the future:

1. Does tumor cell ablation release specific tumor cell death signal?

2. How can freezing produce the best ratio of necrosis and apoptosis?

3. Are the cytokines released after freezing derived from tumor microenvironment or natural immune response, and what is their time sequence?

4. Will the functional essence and time sequence of antigen presenting cells that absorb necrotic tissue change after cryoablation?

5. What is the effect of cryoablation and absorption of necrotic tissue on the immunosuppressive function of the body? How to reduce the immunosuppression of the body?

Expert introduction

　

Professor Yang Yongping.

Chinese people’s liberation army general hospital No.5 medical center

Director, Department of Hepatology and Medicine, PLA General Hospital

Chief physician, professor, doctoral tutor

Silver Star of Science and Technology of the General Logistics Department, winner of special allowance of the State Council

Chairman of the Professional Committee of Liver Diseases of China Research Hospital Association

Director of China Hepatitis Foundation

Director of China Research Hospital Association

Vice Chairman of Liver Disease Professional Committee of Beijing Branch of Chinese Medical Association

Vice Chairman of Liver Disease Professional Committee of Beijing Society of Integrated Traditional Chinese and Western Medicine

Take the lead in the major special topics of the "Thirteenth Five-Year Plan and Twelfth Five-Year Plan" of the country, the key topics of the "Twelfth Five-Year Plan" of the army and the key topics of the Beijing Municipal Science and Technology Commission in integration of defense and civilian technologies; Won one national science and technology progress award, one first prize of Beijing science and technology progress award and six second prizes of military science and technology progress award.

Finishing/platform review/Professor Yang Yongping

This article is only for medical and health professionals to understand information, and does not represent the views of this platform. This information cannot replace professional medical guidance in any way, nor should it be regarded as medical advice. If the information is used for purposes other than understanding the information, the platform and the author shall not bear the relevant responsibilities.

　　CCTV News:According to the WeChat official account news released by Shanghai, the Shanghai Central Meteorological Observatory issued a blue rainstorm warning signal at 12: 30 on August 23rd, 2023: Due to the influence of strong precipitation clouds, it is predicted that there will be precipitation in parts of central and southern Shanghai with a cumulative rainfall of more than 50 mm in six hours before midnight today. Please pay attention to the prevention of urban waterlogging caused by heavy rainfall, and do a good job in drainage and waterlogging prevention in low-lying and flood-prone areas.

　　The yellow warning of lightning issued before is still high.

　　Defense guide:

　　1. Stop carrying out outdoor activities in open places.

　　2. Stop swimming in rivers, lakes and seas.

　　3. Stay away from trees, corners or places with prominent metal objects; Don’t hold objects with sharp metal corners in your hands or carry them on your shoulders.

　　Defense guide:

　　1. Citizens should prepare rain gear to ensure safety.

　　2, drivers pay attention to the road water.

　　Level Ⅳ response of flood prevention platform

　　According to the introduction of the Municipal Flood Control Office, the level IV (level IV) response of the city’s flood control stations started simultaneously.

　　Level 4 (IV) emergency response (blue)

Recently, the Hunan Provincial Health and Health Commission and the Hunan Provincial Department of Education issued the Notice on Strengthening the Prevention and Control of Key Infectious Diseases in Schools in Autumn and Winter. Infectious diseases on campus mainly spread through respiratory tract in autumn and winter, and some spread through digestive tract and contact, so it is easy to break out and spread in campus, so we should pay special attention to prevent the spread of infectious diseases.

According to the epidemic situation and incidence characteristics of infectious diseases, the school hospital has sorted out several knowledge of prevention and treatment of common infectious diseases in autumn and winter, please pay attention to it!

I. Influenza

(A) disease science

Influenza is an acute respiratory infection caused by influenza virus, and it is also a highly contagious and fast-spreading disease. Fog droplets ejected mainly by coughing or sneezing of infected people are transmitted to others through the air, and can also be infected by touching objects contaminated by influenza virus. The main clinical manifestations are high fever, headache, limb aches, fatigue and upper respiratory symptoms such as runny nose and cough. The infirm and the elderly are prone to pneumonia and other complications after infection.

The difference between influenza and common cold

(2) Prevention and control suggestions

1. Before the flu season, it is an effective way to prevent the flu by vaccinating high-risk groups and susceptible groups.

2. Reasonable arrangement of work and rest time: have a regular life, ensure adequate sleep, and avoid the decline of resistance caused by overwork, thus increasing the chance of illness.

3. Pay attention to personal hygiene: don’t spit everywhere, and cover your mouth and nose with a handkerchief or paper towel when sneezing or coughing.

Wash your hands frequently, and wash your hands immediately after touching respiratory secretions (such as after sneezing).

4. Open the window and ventilate several times a day to keep the indoor air fresh. During the high incidence of influenza, try not to go to crowded places with dirty air; You’d better wear a mask when you have to.

5. Effective prevention approaches: early detection, early reporting, early isolation and early treatment. Isolating patients is the most effective way to reduce transmission.

Second, cold diarrhea

(A) disease science

Infectious diarrhea refers to diarrhea caused by intestinal infection of pathogens such as bacteria, viruses, parasites or fungi. Its prevalence is wide, the incidence rate is high, it has the characteristics of acute onset, rapid spread and wide coverage, and it is an important disease that harms health. Mostly due to the intake of unclean diet (such as cold dishes, spoiled shrimp, crabs, drinks, etc.) and water, due to bacterial and viral pollution, coupled with some people’s bad hygienic eating habits, the disease enters the mouth. The clinical manifestation is diarrhea, which may be accompanied by abdominal pain, fever, nausea, vomiting and other symptoms. The stool characteristics often vary with different pathogens, and in severe cases, fever, dehydration, electrolyte disorder, abnormal renal function, acidosis, shock and so on may occur. Infectious diarrhea pathogens are excreted with excreta, which pollutes the environment, food and water sources and can cause outbreaks.

(2) Prevention and control suggestions

1. Pay attention to drinking water hygiene, don’t drink raw water, don’t eat cold and spoiled food, especially seafood and aquatic products.

2. Pay attention to food hygiene, don’t overeat, and eat less food that is easy to carry germs and be bitten by flies; Tableware should be disinfected, and raw and cooked tableware should be separated; Try to eat cooked food, and wash and peel raw fruits and vegetables.

3. Pay attention to personal hygiene, wash your hands before and after meals, do not defecate anywhere, do not dump garbage and dirt, and do not pollute water sources.

4. Report the patients with vomiting and diarrhea in time, and see a doctor as soon as possible for timely diagnosis and treatment.

Third, tuberculosis

(A) disease science

Tuberculosis, also known as "consumption", is a chronic infectious disease caused by the infection of Mycobacterium tuberculosis (commonly known as Mycobacterium tuberculosis). The part often invaded by Mycobacterium tuberculosis is the lung, which is called tuberculosis. The clinical manifestations of tuberculosis are various, and the early symptoms are mild and atypical. It is easy to be confused with other respiratory diseases, such as tracheitis and pneumonia, and it is often ignored, which leads to the delay of medical treatment. Cough, expectoration, hemoptysis or bloodshot sputum are the main symptoms of pulmonary tuberculosis. Most patients with pulmonary tuberculosis have hemoptysis with blood in sputum, and a few patients have hemoptysis with big mouth. In addition, chest tightness, chest pain, low fever in the afternoon, night sweats, general weakness, loss of appetite or weight loss are also common symptoms of tuberculosis.

(2) Prevention and control suggestions

1. Take tuberculosis examination as a compulsory item for physical examination of teachers and students.

2. Do not spit everywhere, cover your mouth and nose when coughing or sneezing, and wear a mask to reduce the spread of tuberculosis.

3. After suspicious symptoms of pulmonary tuberculosis appear or are diagnosed as pulmonary tuberculosis, you should take the initiative to report to the school, and don’t hide your illness or attend classes with illness.

4. Develop the habit of frequently opening windows for ventilation; Do a good job in campus environmental sanitation, and eliminate the dead corner of sanitation.

5. Ensure adequate sleep, reasonable diet, strengthen physical exercise and improve the ability to resist diseases.

Fourth, dengue fever

(A) disease science

Dengue fever is an acute mosquito-borne infectious disease caused by the spread of dengue virus through mosquito bites. Dengue fever has the characteristics of typical importation, suddenness, rapid spread, high incidence, general susceptibility of the population and high mortality of a few severe cases. The clinical features are sudden onset, high fever (sometimes up to 39℃), general muscle pain, joint pain, extreme fatigue, and some patients may have rash, bleeding tendency and lymph node enlargement. At present, the epidemic situation of dengue fever in Southeast Asia, South America, Africa and other places is more serious, and cases of dengue fever have appeared in Yunnan, Guangdong, Zhejiang, Hainan and other regions in China. At present, there are no vaccines and specific therapeutic drugs that can prevent the disease. The focus of treatment is to control pain with painkillers, usually acetaminophen (paracetamol).

(2) Prevention and control suggestions

Avoiding being bitten by mosquitoes is the key. Try to choose light-colored long-sleeved trousers and use mosquito repellent or other mosquito repellent drugs when going out.

2. Screen windows and screen doors should be installed in the residence. You can use mosquito-repellent incense, mosquito-repellent aerosol, etc. in the hotel room before going out. Even in high-end hotels, you should pay attention to indoor mosquito killing. Avoid staying in the dark and humid outdoors such as grass, shade and gazebo for a long time.

3. If symptoms appear, see a doctor in time. If you come back from dengue endemic areas (Yunnan, Guangdong, Zhejiang, Fujian and other domestic endemic areas, Southeast Asia, South America, Africa and other overseas endemic areas), please pay attention to your own health observation. If you have a persistent high fever within 2 weeks, accompanied by symptoms such as headache, orbital pain, muscle and joint pain, nausea, vomiting, rash, etc., you should go to a regular hospital as soon as possible, and inform the doctor of his recent residence history and remind him that he may have dengue fever; When staying at home or in hospital, do a good job in mosquito isolation (especially within 5 days after onset), including using mosquito nets, screen doors and screens, wearing long-sleeved underwear, spraying mosquito repellent and other measures to reduce unnecessary outdoor activities and prevent further spread.

V. Covid-19 infection

(A) disease science

At present, XBB series variants of Omicron subtype have become dominant in most provinces in China, and this trend is likely to continue in the future. The National Bureau of Disease Control and Prevention also said that the epidemic situation of COVID-19 in China is generally at a low level and in a wave-like fashion recently, and the epidemic situation has brought less pressure to local medical systems, so there will be no large-scale epidemic in the short term. However, it should be noted that cases of multiple infections with COVID-19 are more common. Through the search, we can find that the number of COVID-19-infected outpatients in hospitals has increased recently, and most patients are infected with Covid-19 or influenza virus.

(2) Prevention and control suggestions

1. Actively vaccinate. Elderly people aged 60 and above, people aged 18-59 with serious basic diseases, people with low immune function, people with high risk of infection, and people who have completed basic immunization or have been infected with Covid-19 should be actively vaccinated to further strengthen their autoimmune ability.

2. Pay attention to personal protection. Residents should wear masks in their daily trips, minimize unnecessary gatherings and keep social distance. Maintain good personal and environmental hygiene, wash hands frequently, often ventilate, pay attention to rest, pay attention to nutrition and enhance physical fitness.

3. Use drugs rationally and see a doctor as needed. After infection, residents should take corresponding treatment measures according to the severity of their own symptoms, implement self-care at home, reduce contact with their roommates, rationally use symptomatic drugs according to relevant guidelines, do a good job in health monitoring, and go to medical institutions in time if the condition worsens.

Six, monkeypox

(A) disease science

Monkeypox (Mpox) is a viral zoonotic infectious disease caused by Mpox virus. The main clinical manifestations are fever, rash and lymphadenopathy. Recently, many provinces and cities in China reported cases of monkeypox. Monkeypox cases are mainly men who have sex with men. Recently, there have been some cases of infection among women and medical staff.

(2) Prevention and control suggestions

1. Pay close attention to the epidemic information of monkeypox in the local area or travel destination in time to avoid direct contact with wild animals in high-incidence countries. Avoid catching, slaughtering and eating local animals raw.

2. Good hygiene habits, frequent cleaning and disinfection, and good hand hygiene.

3. If you find sex with a rash (especially in genitals, perianal parts, etc.), avoid close contact with it. Using condoms can’t completely prevent monkeypox virus infection.

4. The interpersonal transmission of monkeypox is mainly among men who have sex with men. It is suggested that men who have sex with men actively understand the knowledge of monkeypox prevention to avoid or reduce high-risk behaviors.

5. If you have symptoms such as fever, rash and lymphadenopathy of unknown reasons, you should take the initiative to seek medical treatment.

Seven, dog injury

(A) disease science

Rabies is a zoonotic acute infectious disease. Once it breaks out, the mortality rate is close to 100%. According to the data released by the World Health Organization (WHO), rabies still kills 59,000 people worldwide every year, and one person dies of rabies every 9 minutes, and 99% of the cases are caused by dog bites. Main symptoms (rabies): fear of water, fear of wind, pharyngeal muscle spasm and progressive paralysis. Raising awareness of rabies prevention, vaccinating dogs and strengthening post-exposure treatment of human rabies in epidemic areas are the most effective rabies prevention measures at present, and it is also the global consensus on rabies prevention.

(2) Prevention and control suggestions

1. Pet dog owners must consciously raise dogs in accordance with the law, vaccinate cats and dogs, and use leashes when going out to avoid dogs hurting people and spreading rabies virus.

2. Rabies can be prevented and cured. If you are scratched or bitten by a dog/cat, even if the wound is small, you should not be careless. You should seek medical advice in time. It is recommended to go to a medical institution with relevant qualifications for treatment, and do a good job in handling rabies after exposure according to the wound condition and personal immunization history.

3. After being scratched or bitten by a dog/cat, the individual should give first aid: if the wound is deep, especially the bleeding wound, you should first press the wound with a clean cloth to stop bleeding, and then rush to the hospital; If the wound surface is shallow or bleeding is not much, you can first clean the wound with flowing water or soapy water for 15 minutes, then use a clean paper towel to absorb the residual liquid at the wound, and then cover the wound with a clean cloth and seek medical attention as soon as possible. In addition to preventing rabies, we should also guard against other wound infections, such as tetanus infection.

4. Old people and children should receive more protection. Because the elderly and children have weak self-protection ability and lack of awareness of risk prevention, the incidence of animal injuries is high.

Original title: "It is related to health, beware of these infectious diseases! 》

Read the original text

　　Cctv newsThe eighth round of Geneva peace talks on Syria led by the United Nations was held in Geneva, Switzerland on 28th. On the same day that the peace talks began, the Syrian government decided to send a delegation to participate in the peace talks. It is expected that the Syrian government delegation will arrive in Geneva on the 29th.

　　On the 28th, the Syrian Foreign Ministry confirmed that after discussions with Russia, the Syrian government decided that the Syrian Permanent Representative to the United Nations Jaafari would lead a Syrian government delegation to Geneva to participate in this round of peace talks.

　　De Mistura, the UN Secretary-General’s Special Envoy for Syria, also said that he had received news that the Syrian government delegation had confirmed its participation in the peace talks.

　　Earlier, due to the serious differences between the Syrian government and the opposition on the issue of Syrian President Bashar al-Assad’s stay, the Syrian government delayed confirming its participation.

　　On the 27th, the Syrian opposition delegation that has arrived in Geneva said that the primary appeal of the opposition to participate in this round of peace talks is to ask Bashar to step down before the political process starts. Earlier, a senior official of the Syrian government said that the Syrian opposition’s "laying down arms" was a prerequisite for the success of the peace talks. Due to serious differences between the two sides, the Syrian government delegation postponed its trip to Geneva.

　　UN envoy meets Syrian opposition delegation

　　On the 28th, the eighth round of Geneva peace talks on Syria was officially opened. On the same day, UN Secretary-General’s Special Envoy for Syria, De Mistura, held talks with the Syrian opposition which formed a unified delegation in Geneva.

　　UN Secretary-General’s Special Envoy for Syria, De Mistura, said after meeting with Syrian opposition representatives on the 28th that the United Nations would propose for the first time that the Syrian government delegation and the Syrian opposition delegation should have a direct dialogue.

　　Whether the negotiating parties can "talk directly" is highly anticipated.

　　All along, the Geneva peace talks have been in the form of "indirect talks", that is, the UN Secretary-General’s Special Envoy for Syria acts as a mediator to communicate and communicate between the two sides. The representatives of the Syrian government and the opposition have not met directly. De Mistura said that it is not yet known whether the two sides will agree to direct dialogue, but the United Nations will put forward this proposal.

　　The Syrian opposition delegation formed a unified group for the first time.

　　De Mistura also said that there were many Syrian opposition factions that had participated in the Geneva peace talks many times before, and no unified delegation was formed. Before the opening of the peace talks, the Syrian opposition held a meeting to coordinate its position and formed a unified opposition delegation.

　　The Syrian government has agreed to cease fire in Dongguta area.

　　De Mistura also said that after communicating with the Russian side, the Syrian government has agreed to implement a ceasefire in the Dongguta area in the eastern suburb of Damascus, the Syrian capital. In the past few years, opposition forces have controlled the Dongguta area and frequently launched shelling into Syrian government-controlled areas, causing a large number of civilian casualties.

　　De Mistura, the UN Special Envoy for Syria, said that the new round of peace talks needs to have a new focus and be practical. Under the current circumstances, the Geneva peace talks have been fully prepared on how to promote the political settlement of the Syrian crisis.

　　De Mistura affirmed the role played by China.

　　On 28th, UN Secretary-General’s Special Envoy for Syria, De Mistura, met with China’s Special Envoy for Syria, Xie Xiaoyan. De Mistura fully affirmed China’s efforts and role in the Syrian issue.

　　The new round of peace talks still focuses on the "four baskets", namely, the formation of a national unity government, the revision of the constitution, the holding of general elections and anti-terrorism cooperation. Among them, amending the constitution and re-election will be the top priority. Xie Xiaoyan, the special envoy of the China administration on Syria, said that these two issues are crucial to promoting the political process on Syria.

　　Earlier in the day, De Mistura also held talks with representatives of the permanent members of the UN Security Council. De Mistura said that the talks with the representatives of the permanent members are very important. On the one hand, it can prepare the agenda of the talks, on the other hand, it can consolidate and strengthen the importance and authority of the Geneva peace talks, because the Geneva peace talks are the only political settlement process of the Syrian issue authorized by the Security Council.

　　The Syrian government is late and the opposition is early.

　　In the previous Geneva peace talks, the Syrian government delegation arrived at the venue in advance and waited for the arrival of the opposition. This time, the current round of peace talks started on the 28th, and the head of the Syrian opposition peace talks delegation Hariri arrived in Geneva on the 27th, while the Syrian government delegation will arrive in Geneva on the 29th. Experts believe that this is related to the current battlefield situation in Syria.

　　Geneva peace talks on Syria

　　Before this round of peace talks, the Geneva peace talks on Syria have been held for seven rounds, but due to the serious differences between the Syrian government and the opposition, many rounds of peace talks have not achieved substantive breakthroughs.

　　In December 2015, the United Nations Security Council unanimously adopted resolution 2254 aimed at promoting a political solution to the Syrian conflict, and decided to launch formal peace talks between Syrian factions led by the United Nations, which will be held at the Palais des Nations in Geneva.

　　According to this resolution, the current Geneva peace talks mainly include four topics: the establishment of a transitional government of national unity in Syria, the formulation of a new constitution, the holding of general elections and the joint efforts of all parties to fight terrorism. These four topics are also called "four baskets".

　　The differences between the parties are serious and it is difficult to achieve substantive progress.

　　Since January 2016, the parties to the Syrian issue have successively held several rounds of "Geneva Peace Talks on Syria". However, in the previous rounds of negotiations, the differences between the parties have been very serious. Even on the discussion order of the "four baskets", it is difficult for the Syrian government and the opposition delegation to reach an agreement. Moreover, the two sides can’t hold direct talks in the negotiations, but only indirect talks, which means that the United Nations needs to hold talks with the Syrian parties separately, and then shuttle messages between the parties. In this case, many rounds of negotiations failed to achieve substantive results on any topic.

　　Gradually but failed to break through the end of the seventh round of peace talks.

　　From July 10th to 14th, 2017, the seventh round of "Geneva Peace Talks on Syria" was held. This round of peace talks is still an indirect dialogue. After the seventh round of peace talks, UN Secretary-General’s Special Envoy for Syria, De Mistura, said that this round of peace talks has made some progress, but no substantive breakthrough has been made. On three topics except the establishment of a transitional government, the Syrian government and the opposition held many technical discussions to pave the way for substantive discussions; At the same time, a certain consensus has been reached on anti-terrorism and the prohibition of banned weapons. De Mistura said that the two sides are not far from substantive discussions.

　　Expert: US policy toward Syria is still unclear.

　　In addition to the great changes in the domestic situation in Syria, the involvement of external forces is another background that cannot be ignored. With extremist organizations losing ground in the Syrian battlefield, will the US policy toward Syria be adjusted?

　　Daniel Sevo, an American expert on Middle East issues, said that with the new round of Syrian peace talks, many American observers did not have high expectations for the outcome of the peace talks. In particular, the recent statement of US Secretary of Defense Matisse also shows that the US will not immediately withdraw its troops from Syria.

　　On November 13, US Defense Secretary Matisse said at the Pentagon that the US military will maintain a military presence in Syria for a long time to prevent the emergence of new extremist organizations. On November 24, US President Trump said in a telephone conversation with Turkish President Erdogan that the United States will no longer provide weapons and equipment to Kurdish armed forces in Syria. These actions also show that the United States is readjusting its Syrian policy.

　　However, experts said that from the current point of view, the US policy toward Syria is still unclear.

　　As the battle against extremist organizations in Syria is coming to an end, the United States is reassessing its policy toward Syria. Some observers said that no matter what adjustments the US makes, the US military will not leave Syria easily.　　

According to CCTV news, according to a report by the Japan Broadcasting Association on March 27th, local time, the Japanese Ministry of Health, Labor and Welfare announced the second death case suspected of taking a health product containing monascus from Kobayashi Pharmaceutical Company on March 26th, and the number of people admitted to the hospital has increased to 106.

Earlier, the Japanese Ministry of Health, Labor and Welfare had investigated Kobayashi Pharmaceutical Company and found that there was a new death report in addition to a previously announced death case.

Based on the Food Hygiene Law, Japan’s Ministry of Health, Labor and Welfare has asked Osaka headquarters where Kobayashi Pharmaceutical Company is located to take measures including product abandonment.

In view of the fact that many people were hospitalized and two people died after taking products containing monascus from Kobayashi Pharmaceutical Company, the Japanese Ministry of Health, Labor and Welfare will hold a meeting with the Consumer Department, the Ministry of Agriculture, Forestry and Fisheries and other relevant departments on the 27th to discuss future countermeasures.

According to Japanese media reports on the 27th, the Osaka municipal government of Japan ordered Kobayashi Pharmaceutical Company to recall three products, including "red yeast cholesterol granules".

Consumers die after taking health care products.

Kobayashi Pharmaceutical Emergency Recall

Previously, Kobayashi Pharmaceutical Co., Ltd. said that a consumer who took the company’s health care products containing monascus ingredients died of kidney disease. Some consumers suffer from diseases in kidney and other parts after using this health care product, and they are hospitalized, and some even need dialysis.

On March 26, Kobayashi Pharmaceutical updated the notice asking consumers to stop using the company’s products containing monascus ingredients and to recall them independently. According to the notice, the consumer took the company’s health care product containing monascus ingredients-monascus cholesterol granules. However, the notice did not disclose the relevant information of the consumer and the time of death.

The notice said that it has been confirmed that the consumer continued to buy red yeast cholesterol granules from April 2021 to February 2024. The company is investigating whether there is a causal relationship between the consumer’s death and taking the above health care products.

According to Kyodo News, since February 2021, monascus cholesterol granules have been sold in e-commerce channels and stores, and about 1.06 million bags have been sold by the end of February this year.

Three products involved
Are health care products for improving cholesterol.

The following is a list of three recalled products released by Kobayashi Pharmaceutical Company official website, all of which are health products for improving cholesterol. Please be careful not to buy or continue taking it.

China e-commerce platform removes products involved.

Consumers can return goods and get a refund.

Kobayashi Pharmaceutical Co., Ltd. is an old Japanese pharmaceutical company with a history of more than 100 years, and many of its products are quite popular. According to the company, monascus is a raw material produced by mixing monascus with steamed rice for fermentation. The company publicizes that this ingredient is expected to reduce the cholesterol value of low density lipoprotein.

The reporter searched a number of domestic e-commerce platforms and found that there are currently no three related products sold on the official e-commerce platform of Xiaolin Pharmaceutical, but there are still purchasing merchants selling related recalled products.

Kobayashi Pharmaceutical China Company said, "The company has received reports that it may cause kidney diseases and other problems after eating, and some of its products are sold to China through cross-border channels. If a consumer has eaten it and feels unwell, contact customer service, and the products that have not been eaten will be returned and refunded. "

On March 22nd, @ Kobayashi Pharmaceuticals issued a notice to remind consumers who have red herring cholesterol granules (60, barcode 4987072059708) to stop eating.

Up to now, the products involved have been removed from the official store of Kobayashi Pharmaceutical, the e-commerce platform mentioned in the notice. According to the reporter’s inquiry, multiple e-commerce platforms have been unable to search for this product.

Kobayashi pharmaceutical president bowed and apologized.

Admit that decision-making is slow

On the evening of March 22nd, President Kobayashi held a press conference and bowed to apologize for this issue.

According to Japanese media reports, the analysis results on the 16th of this month showed that some raw materials of monascus may contain unknown ingredients, but the company did not announce the recall until the 22nd. In this regard, the president of Kobayashi Pharmaceutical admitted that the decision was slow.

Another five Japanese companies issued a recall announcement.

Among the 18.5 tons of monascus raw materials produced by Kobayashi Pharmaceutical in 2023, about 16 tons of raw materials were sold to other companies for brewing and food manufacturing, except for their own health care products. At present, Kobayashi Pharmaceutical has issued a recall request to all 52 enterprises that purchased its monascus raw materials through its sales company. Affected by this, some food, brewing and other enterprises that use Xiaolin Pharmaceutical’s red yeast raw materials have also announced the recall of related products.

It is understood that the company is working hard to confirm the sales partners and recalls, and it is expected that the recall scale will be further expanded.

The reporter’s investigation found that at present, five Japanese companies have issued relevant recall announcements and announced related products. The names of the five enterprises are respectively Baojiuzao Co., Ltd., ZERO PLUS Co., Ltd., Doufu Co., Ltd. Nagoya Store, Takeya Co., Ltd. and Jiwen Food Co., Ltd.

Baojiuzao Co., Ltd.

On March 24th, Japan Baojiu Brewery Co., Ltd. announced that it had decided to recycle about 96,000 bottles of this product by itself because a wine produced by this company used red yeast raw materials provided by Kobayashi Pharmaceutical Company. At present, there are no reports of health damage related to this product of Baojiu Brewery Company.

According to the wine manufacturer, this wine has only been exported to Singapore and Taiwan, China, and has not entered the Chinese mainland market.

ZERO PLUS co., ltd

Japan’s ZERO PLUS Company issued a recall notice on March 22nd, saying that there may be unknown ingredients in the raw materials of red yeast in the thick cheese biscuits sold by its KUMITE brand. At present, the specific information of this ingredient cannot be determined. In order to prevent the safety problem from further expanding, it will be recycled independently from now on.

Doufu corporation company Nagoya branch

The recall announcement issued by the Nagoya Pastry Store of Doufu Co., Ltd. said that because its eight products contain red rice malt ingredients produced by Kobayashi Pharmaceutical, there are potential health risks, so they will take the initiative to recall these products and suspend sales.

Takeya corporation

On March 25th, Takeya, a Japanese miso production company, issued a notice that the product "Low-salt Monascus Miso" used the raw materials of Monascus produced by Kobayashi Pharmaceutical, and the sales of this product will be stopped from now on and recycled independently.

Jiwen food co., ltd

Japan’s Jiwen Food Company issued a notice on March 24th, stating that the products "domestic squid pickled products" and "squid pickled products" used the raw materials of red koji produced by Kobayashi Pharmaceutical, so they were recycled independently from now on. If the products are sent to the address designated by the company, the company will refund the payment in the future.

Xiaolin Pharmaceutical’s market value evaporated by over 4.2 billion yuan.

It is reported that Kobayashi Pharmaceutical (China) Co., Ltd. is a wholly-owned subsidiary of Kobayashi Pharmaceutical Co., Ltd.

According to the national enterprise credit information publicity system, Kobayashi Pharmaceutical (China) Co., Ltd. was established in Shanghai on April 9, 2018 with a registered capital of US$ 77,982,400. The legal representative is Matsushita Tuoye, and the company is 100% owned by Kobayashi Pharmaceutical Co., Ltd.

As of the morning of 27th, the share price of Kobayashi Pharmaceutical Co., Ltd. fell by 3.53%, with a total market value of 381.7 billion yen. Since the fermentation of the event, Kobayashi Pharmaceutical has fallen by nearly 20%, and its total market value has evaporated by more than 90 billion yen (about RMB 4.29 billion) compared with the closing on March 22.

Netizen: I didn’t expect health care products to be fatal.

In response to this matter, some netizens said that it was "terrible", "too scary" and "I didn’t expect health care products to be deadly", and some netizens were worried about whether other products such as warm babies and antipyretic stickers of this brand could still be used.

(Yangcheng Evening News Yangcheng School Comprehensive CCTV News, Beijing Daily, Xinhua News Agency, China News Network, Zhongxin Jingwei, Overseas Network, Beijing Youth Daily, User Comments)

Original title: Health care products are still dying? 2 deaths and 106 people have been hospitalized! Kobayashi Pharmaceutical urgently recalled, and these products should also be noted →　

　　[Bourne ultimatum] It’s another weekend in a blink of an eye, and the new issue of Bourne ultimatum meets with you. There are many heavy models in this week’s spy photos. Domestically, there are two new cars, the new RAV4, the production version, and the speed car, and the domestic L; Overseas, there are brand-new Q5, brand-new, brand-new and brand-new G-class Toyota. Next, let’s walk into the text and see the specific situation of these 9 cars.

● Zotye Damai X7

　　All along, we can find the shadow of existing models of overseas brands in many models of Zotye. However, when faced with the BMW X7, many people may be confused, but don’t rush to deny their knowledge reserves, because this car is not a production model, but a GTE. Obviously, Zotye beat us to it.

　　Damai X7 has a high degree of restoration for the appearance of Cross GTE concept car, including the front face layout and tail shape. On the side, the lines of the Damai X7 are straighter, which is not as exaggerated as the Cross Coupe GTE concept car.

　　In the interior part, Damai X7 still draws lessons from the design of the Cross Coupe GTE concept car, and even the details of the air conditioning outlet, buttons and chrome-plated decorative parts are exactly the same as the Cross Coupe GTE concept car. However, the shift lever of the manual transmission model has no sense of design, which is not very harmonious with the overall design.

　　As for the power system, Damai X7 will provide three power options, namely 1.5T, 1.8T and 2.0T. In terms of transmission system, it is matched with 5-speed manual or 6-speed.

　　Editor’s comment:Every time Zotye launches a new car, it will become the focus of consumers’ attention, because there is really no manufacturer in the market that can reverse develop overseas car companies on a large scale like Zotye. From the earliest, to the next, Zotye’s imitation road has embarked on the "first cosmic speed". What drives Zotye to go on like this is not only high attention, low research and development cost, but also good market response. For example, the monthly sales of Zotye are often above 10,000 vehicles, and in the first five months of 2016, it also sold 43,284 vehicles.

　　Although many people will show disdain for such a product, the sales data reflect that it still has a large market. This shows that Zotye’s ability to grasp consumer demand and market hotspots is still very good. This time, the concept car that Volkswagen has not yet mass-produced is used as a blueprint to imitate, and Zotye has even walked in front of the public. Since I have such a vision, I still hope Zotye can bring us more original designs, which is really ahead of other brands.

　　Read more:

　　Two Interior Styles Zotye Damai X7 Latest Real Car Map Exposure

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● FAW Toyota new RAV4

　　The market has always been one of the main battlefields among the major players. Although it is an old player, the sales performance of RAV4 has no advantage over competitors. The reason is that the configuration is one aspect that many consumers are dissatisfied with, so the new RAV4 came into being, and the new car was upgraded in the configuration part, further enhancing its competitiveness.

　　The new RAV4 continues the design of overseas models in appearance. The main change lies in the front face, the air intake grille above becomes very long and narrow, and the modeling details of the front bumper below are also adjusted. At the rear, the new car redesigned the details of the taillights and bumpers.

　　In the interior, we can see that the overall design of the new car has not changed, but some models have added a 7-inch central control LCD screen and a dashboard with a 4.2-inch LCD screen. In the configuration part, automatic start-stop and body stability systems, systems and systems are added to the entry-level models. The configuration of other models has also been improved to varying degrees, which will increase functions such as panoramic image system, outdoor (with heating), keyless entry (one-button start), and uphill assistance. On the whole, the new RAV4 has a significant improvement in configuration.

"3ZR-FAE engine for overseas models"

　　In terms of power, the new RAV4 is still equipped with 2.0L and 2.5L engines, of which the 2.0L engine is a new engine code-named 3ZR-FAE, and its maximum horsepower is increased from 147 HP to 150 HP. Due to the continuous lift technology, its fuel consumption performance is worth looking forward to.

　　Editor’s comment:For consumers who are concerned about RAV4, the upgrade of this configuration should be the most attractive. The current models are not equipped with traction control and body stability control system as standard, which makes some consumers finally choose other products. The new models have been improved in these aspects, and are fully equipped with body stability system, traction control system and uphill auxiliary system, and other configurations have also been upgraded. FAW Toyota has made positive adjustments to the feedback from the market, which is very worthy of recognition.

　　In addition to the configuration, we need to pay attention to the replacement of a new 2.0L engine. Although the new engine has little improvement in power performance, according to the introduction of Toyota manufacturers, the continuous variable lift technology can reduce fuel consumption by 5-10%. For RAV4, which is biased towards home, low fuel consumption is undoubtedly an attractive selling point, which is worth looking forward to. It is expected that the price of the new car will not change much, and it may still remain in the range of 180,000-270,000 yuan.

　　Read more:

　　Or the new RAV4 configuration will be exposed on July 28th.

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● Concept B production version

　　As an evergreen tree in the China brand SUV market, Haval’s every move will attract the attention of many consumers, and so will this production version of Concept B. Concept B is a production version, focusing on young and fashionable consumer groups.

　　The production version of Harvard Concept B locates a small SUV, which will be sold at the same time as H2 in the future. In terms of appearance, this car adopts a typical blue standard style, such as hexagonal air intake grille and sharp headlights, which is very similar to other blue standard models.

　　On the side, this car largely retains the design of the concept car. The waistline rises backwards, creating a running posture. At the rear, the Concept B concept car uses two exhaust ports on both sides. Referring to the car body parameters of the concept car, the length, width and height of the car body of Concept B are 4146/1772/1623mm and 2550mm respectively, which is slightly smaller.

　　The interior of the production version of Concept B is also quite individual. The center console is equipped with a large-size LCD screen, and the layout style of buttons at the bottom of the screen is the same as that of the blue standard H2. On the right side of the center console, chrome-plated decorative pieces are integrated with the air-conditioning outlets on both sides, which is very novel. In terms of configuration, the new car is equipped with functions such as reversing radar, keyless entry and one-button start. At present, the power information of the car has not been exposed.

　　Editor’s comment:In terms of body size, the production version of Haval Concept B is a small SUV between Haval H1 and H2. It is closer to the Haval H2 blue standard in terms of body size and design, and it is also likely to be equipped with a 1.5T engine in terms of power. In terms of price, the current price of Haval H1 is 54,900-82,900 yuan, and the price of Haval H2 is 88,800-12,800 yuan, of which Haval H1 focuses on the market of about 70,000 yuan, and Haval H2 focuses on the market of about 100,000-110,000 yuan. Therefore, in the market of 800,000-100,000 yuan, Harvard still has potential to be tapped, and Concept B was born for this purpose. It is estimated that the final price of this car will be around 700,000-110,000 yuan.

　　Although it is said that having more children is easy to fight, it does not mean that children will not fight. At the same time, three products are laid out in the small SUV market, which is rare in car companies. To handle the relationship between these cars well, we must do a good job in vehicle positioning, configuration level, pricing and market strategy, so that the three can be in their respective positions and form a joint force, which will be a difficult problem before Harvard. In addition, I have a question. Since this car is positioned between H1 and H2, how will it be named? Haval H1.5?

　　Read more:

　　Provide manual transmission Haval Concept B production spy photos.

　　In the history of contemporary literature in China, there is a saying that "three reds and one creation, the mountains are green and the forests are protected", which refers to eight novels that were created in the 1950s and 1960s and had a great impact on society, namely Red Rock (Luo Guangbin and Yang Yiyan), Red Sun (Wu Qiang), Red Flag Spectrum (Liang Bin), Entrepreneurship History (Liu Qing) and. These novels are different from other classic works born in the same period, such as the novel Fight to Tomorrow (White Blade), Iron Wall (Liu Qing), The Story of the Wind and Cloud (Sun Li), flying tigers (Knowing Xia), Spring and Autumn in a Small Town (Gao Yun Lan), Fighting Youth (Xue Ke) and Wildfire Spring Breeze Fighting the Ancient City.

　　Epic and heroic character are the most striking features of these red literary classics. With a strong sense of epic and a high degree of artistic generalization, they respectively reflect the arduous struggles during the period of new-democratic revolution and socialist revolution and construction from different aspects and angles, and truly show the glorious and arduous course that China people have gone through under the leadership of the Communist Party of China (CPC) in various historical periods, which has profound educational significance and strong inspiration. Therefore, in the history of contemporary literature in China, these works are also called "revolutionary historical novels".

　　The authors of "revolutionary historical novels" are mostly the witnesses of the revolutionary history they tell. Just as Tie Ning, chairman of Chinese Writers Association, summarized the revolutionary career and literary career of Xu Guangyao, the author of Fire in the Plain and Private Zhang Ga, they "did not go to the battlefield for writing, but stood at the crossroads of life and death with the people of China in that era filled with blood and fire". And those difficult and tortuous revolutionary experiences provided them with a steady stream of life energy. "As long as you pick up a pen and let your thoughts go back to that era, you can regain your strength and live and write tenaciously with a hundred times of courage and will. It is in this sense that writing presents its value higher than life. "

　　The red classics have left us many familiar heroes and shining images of Communist party member. Song of Youth is full of youthful elegance and intellectual woman Lin Daojing who bravely pursues democracy and freedom. Jiang Jie, a revolutionary martyr who endured torture, was unyielding, cherished lofty ideals and was not afraid of sacrifice in Red Rock; Liang Shengbao &hellip, an ordinary worker who is hardworking, simple and persevering in the History of Entrepreneurship, insists on starting a business despite hardships; &hellip; These lifelike heroes show us the indomitable and heroic revolutionary spirit of the Chinese nation. With the red classic works deeply rooted in people’s hearts, these outstanding images of communist party member have inspired generations to struggle for communist ideals and beliefs.

　　In addition to the magnificent novels, writers have also left many famous literary works of other genres. Writers such as Sun Li, Ru Zhijuan, Serina Liu, Jun Qing and Wang Yuanjian have incorporated more personal perspectives and personal experiences in their short stories, such as Memories of the Mountain (Sun Li), Lily (Ru Zhijuan), Riverside at Dawn (Jun Qing), Party dues (Wang Yuanjian), Music of Heroes (Serina Liu) and Wan.

　　Poets such as Ai Qing, Li Ji, Li Ying, Cang Kejia, Yan Chen, Zhang Zhimin, Ruan Zhangjing, Guo Xiaochuan, Wen Jie and He Jingzhi joined in the chorus of praise for the Communist Party of China (CPC), China Revolution and New China, such as To the Sun (Ai Qing), To Kunlun (Li Ji), Li Dazhao (Cang Kejia) and Zhanghe Water (Ruan Zhangjing Qing Sha Zhang (Guo Xiaochuan) and Love Song of Turpan (Wen Jie) have all become famous works. It is worth mentioning that He Jingzhi’s Song of Lei Feng has played a special role in praising Lei Feng, an outstanding Communist party member in new China.

　　In terms of prose, reportage and newsletter features, in addition to "Remember a spinning wheel" (Wu Boxiao), "Who is the cutest person" (Wei Wei) and "The example of the county party secretary &mdash; &mdash; Jiao Yulu (Mu Qing, fengjian, Zhou Yuan) and other works, the large-scale series single spark can start a prairie fire and the large-scale series Red Flag Fluttering have also become unforgettable memories for a generation. The former clearly and completely reflects the history of the birth, struggle, growth and development of the People’s Liberation Army, while the latter specifically publicizes the history of the glorious struggle of the people of the Communist Party of China (CPC) and China to young readers, eulogizes the martyrs and heroes in China’s previous revolutionary struggles in the past hundred years, and encourages the younger generation to March bravely into infinitely beautiful socialism.

　　Since the beginning of the new era, the literary creation with red theme has still set off a wave again and again, and has been explored and expanded in the new era background, resulting in Oriental and Red Ribbon on the Earth (Wei Wei), Garland under the Mountain (Li Cunbao), Bright Sword (Dou Liang), Historical Sky (Xu Guixiang) and Liberation War (Wang Shuzeng).

　　(Reporter Rao Xiang)

Special feature of 1905 film network Doctor Strange’s cross-border "invention madman" Edison, General zod became "business tycoon" westinghouse.The X-Men beast turned into Tesla, an "electric genius", and Spider-Man acted as Insull, a "scientific rookie".

Such a cross-dimensional combination can only be seen in new films.

　

"Battle of Electricity" poster

The film is a collection of four famous actors, which takes us back to the era of the second industrial revolution more than 100 years ago and witnesses the "power war" that changed the course of human history.

　

In the movie, this war between DC and AC is not only a game between technology and commerce, but also a torture of morality and humanity.

　

These familiar names, such as Edison, Tesla and westinghouse, have also changed from words with no temperature in books and trademarks to vivid, three-dimensional and flesh-and-blood characters.

Is the power war in history as ups and downs as in the movie, and are the lives and past of the three talented giants more legendary than in the movie?

　

01　What’s the battle for electricity?

In the 1970s and 1980s, after Edison invented the electric light with extensive use value, the next step was how to push the electric light to the market and enter every household in the United States.

　

Edison chose DC power distribution system, while his rivals westinghouse and Tesla have been working on AC power. In this way, the "war" between DC and AC is imminent.

The advantages and disadvantages of both are obvious. Direct current can’t be transmitted over a long distance. It requires a power station within every square mile, which is only suitable for crowded towns. In addition, raising or lowering the DC voltage also requires complex circuits.Alternating current can not only be transmitted over a long distance, but also can be boosted and stepped down conveniently through a transformer, so as to transmit electric energy more effectively and at a lower cost.

In the process of the two sides attacking the city, the advantages of alternating current in long-distance transmission and cost are becoming more and more obvious.

　

In 1893, the Chicago World Expo chose Westinghouse Electric of westinghouse to supply power for the exhibition.

　

At the opening ceremony, Tesla held a wire in one hand and a light bulb in the other, lighting 90,000 light bulbs at the same time, which shocked the audience and shattered the rumors about the safety of alternating current.

The Battle of Electric Power (Part II) restored the splendor of the 1893 Chicago World Expo.

　

Three years later, Niagara Falls Power Company awarded the contract for the development and implementation of long-distance transmission technology to Westinghouse.

　

The "Niagara Hydropower Station" designed by Tesla and others has been in operation for more than a hundred years and has become a major scientific initiative of mankind.

The victories of Westinghouse Electric and Alternating Current in these two iconic "battles" made the victory of this electric power negative.

Niagara Falls

However, from a long-term point of view, at present, household appliances and IT products (such as mobile phones and computers) all use direct current.

　

In ultra-long distance high voltage transmission, DC has more advantages than AC. By the end of 2018, China had built 14 DC UHV lines.

Zhundong-southern Anhui UHV DC transmission project

　

In reality, the "electric power war" is not a winner or loser. The collision of several "super brain" in technology and commerce has jointly promoted the technological revolution of human society.

　

02　Edison who stepped off the "textbook"

　

"Steve Jobs Biography" wrote: "After a hundred years, we will definitely remember him. History will put him in the pantheon alongside Edison and Ford. "

　Thomas Edison (historical data map)

This sentence reflects Edison’s position from the side. He is the "king of inventions" across the ages, with more than 1,500 invention patents, ranking ninth among the 100 people who have influenced the United States. Hoover, the 31st president of the United States, commented: "He is a great inventor and a benefactor of mankind."

However, "Battle of Electric Power" has to "invite Edison down from the altar", and it also shows us a king of invention who is more flesh and blood than the textbook.

Edison received only three months of formal education, and his educational level was not high. Although he had amazing creativity, he lacked mathematical knowledge and insight into complex theories. He is good at trial and error through a lot of experiments, but not at theoretical summary.

　

Tesla once commented on Edison: "His way is the most inefficient, just like looking for a needle in a haystack, all by luck. With a little theory and calculation, he can save 90% of his labor. "

　

This fundamental difference in concept is also an important reason why the two parted ways.

Edison was very good at self-marketing. Many of Edison’s inventions are the results of collective labor, but Edison’s name is often seen in the reports.

　

He built his laboratory in Menlo Park, New Jersey into a "world invention factory", and he is the spokesman of the brand.

　

Edison’s company maintains an "arbitrary" production workshop mode, and Edison is in control of what technology and products are used.

　

As shown in the film, Edison in history was also a master of manipulating public opinion. He loves being interviewed and is good at using the media to build momentum for himself.

In order to attack his opponent, he personally compiled a 61-page booklet to tell the lethality of alternating current, and also planned many "death performances".

　

For example, in public, Edison electrocuted dogs, sheep, horses and other animals with alternating current, and even an elephant, and contacted the media for hype, creating a public opinion atmosphere in which alternating current was dangerous and deadly.

More controversially, Edison indirectly promoted the invention and use of the "electric chair" in order to further connect alternating current with "death".

　

Francis Kemler, a "wife killer", became the first prisoner to be executed by the electric chair. The whole process was cruel, and Kemler was electrified three times before he finally died. During the process, his body twitched violently and his muscles were burnt.

The death penalty, which should represent a more Gao Wenming degree, backfired, causing great controversy at that time. Since 1980s, the electric chair has been gradually replaced by poisonous needle injection.

　

No one is perfect, and Edison’s imperfection will not erase his contribution to the development of human science and technology. Let Edison go out of the plane of the textbook and become a living person, which is exactly what War of Electric Power is trying to do.

03　Tesla "Closest to God"

　

Although Edison’s direct opponent in The Battle of Electricity is westinghouse, his feud with another "genius", nikola tesla, is even more legendary.

　

Tesla is an immigrant of Serbian origin. He loved physics and technology since he was a child. He once regarded Edison as an idol and was even more proud of being able to enter Edison’s company.

Nikola tesla (historical data map)

　

In 1884, 28-year-old Tesla traveled across the ocean to new york, USA, with a letter of recommendation from his former employer to Edison, which wrote: "I know there are two great people, you (Edison) are one of them, and the other is this young man."

However, after really starting work, Tesla gradually discovered the huge differences between the two.

　

Edison promised that Tesla would get a $50,000 bonus after transforming the DC generator, but when Tesla asked for the cash, Edison replied coldly: "You don’t understand our American humor."

Tesla in the movie (nicholas hoult)

　

It can be said that both of them are incompatible in character and concept. Tesla is aloof and arrogant, pursuing fashion, and hates Edison’s untidiness.

　

Tesla pays attention to theory and thinks that Edison’s "trial and error" is a waste of time, while Edison believes in practice and in turn accuses Tesla of being an unrealistic "scientific poet".

　

More crucially, Tesla firmly believes that alternating current is the future and is obsessed with turning the alternating current generator in his mind into reality, while Edison is dismissive of it.

In less than a year, Tesla parted ways with Edison. After unemployment, Tesla once dug ditches for his livelihood and failed to start a business. Thanks to the support of westinghouse, his dream finally came true.

　

In addition to the AC system, Tesla has also done research in wireless communication, solar engines, radar systems, robots and other fields, and many discoveries and inventions have surpassed the scientific and technological eras at that time.

After Tesla’s death, the FBI confiscated all his design drawings and experimental works, and all kinds of rumors about his "super power" added mystery.

　Nikola tesla (historical data map)

Among the three, Tesla seems to be the most "like" scientist. He not only has a superior IQ, but also has all kinds of anecdotes and quirks of Frankenstein.

　

He has obtained nearly a thousand patents in his life, but he has been living in poverty and in debt. He never married, and finally died alone in Room 3327 of the New Yorker Hotel.

　

Tesla once said: "Electricity has injected the most precious things into my tired and weak body-the vitality of life and the vitality of spirit."

　Nikola tesla (historical data map)

　

On July 1st, 2003, martin eberhard and Mark Tapenning named the company "Tesla Motors" to commemorate the idol nikola tesla, which also made the name deeply rooted in people’s hearts in another form.

04　Low-key founder of Westinghouse

Compared with Edison’s household name and Tesla’s legend, westinghouse is the most low-key one.

　

In 1869, westinghouse Electric Company (Westinghouse Electric Company) was formally established, and gradually recruited professionals to start the research on alternating current.

George Westinghouse (historical data map)

　

Westinghouse is more willing to be the manager behind the great inventions than the inventor who shows off the limelight. He is good at exerting personality charm and management talent, attracting talents from all walks of life and making the best use of them.

　

These "geniuses" include Tesla. Tesla called himself a "perfect cooperation" with westinghouse, because he was better than theory, while westinghouse knew how to put these crazy ideas and abstract theories into practice and turn them into products.

Stills of "Battle of Electricity"

Westinghouse and Edison are like two sides of a coin. The former never refuses to interview and hates taking pictures. Before his death, he destroyed all his personal documents, hoping that future generations would know himself through his inventions and deeds.

　

In 1911, the American Society of Electrical Engineers awarded westinghouse the highest honor. Interestingly, this medal was named after Edison.

Stills of "Battle of Electricity"

At the end of the film, at the Chicago World Expo, westinghouse and Edison, the old enemies, completed the "Meeting of the Century".

Edison recalled the excitement when he first experimented with a light bulb that could work continuously for 13.5 hours: it was not someone’s success, but a collective leap of human civilization.

Stills of "Battle of Electricity"

Just like the "Great Harmony in the World" written by calligraphers in the China booth beside them, this "war" is a cruel commercial competition, but the greatest creativity is constantly generate in the conflict. This is of more profound significance to this extremely divided society.

Finally, the director uses Tesla, played by Nizi, to tell the main idea of the film: "Rock will shatter, paper will be brittle, bones will turn into powder, and only those immaterial thoughts will run through ancient times and become eternal. Those are the treasures we should leave behind. It is also the power for human beings to move forward. "