Therefore, Song Jia’s styles in the film were designed by the director Jianqi Huo himself. "Many people may suddenly realize that the style of the Republic of China can still be dressed like this after watching Xiao Hong. In fact, Xiao Hong is the fashion pioneer of the Republic of China. As a well-known Shanghai writer, she is the trend leader. Even now, her dress is still very popular. Whether it is a young literary woman or a white-collar woman in the workplace, Xiao Hong’s single items can be used. " Some netizens who have seen the stills in advance laughed and said: "It is estimated that the same paragraph will be popular in Taobao!"
　
　　　 Song Jia bluntly said, "Xiao Hong" is the most exquisite costume collocation he has ever encountered since filming. "The director is very demanding. He hopes that every detail can reflect Xiao Hong’s feelings. We have been choosing clothes, and we must be beautiful enough and literary. We must reproduce Xiao Hong in the original way. Xiao Hong’s literature and art in his heart are colored." The hard work of the director and the staff was not in vain. "Xiao Hong has been wandering from place to place all her life, suffering from poverty and illness. No matter how poor and hungry she is, she will let herself go out gracefully.The biggest feeling of 18 models for me is that they can guide me to enter the state of Xiao Hong quickly. "

Next page: Song Jia: Xiao Hong is the real literary young woman.

On November 29th, China declared "China’s traditional tea-making skills and related customs" included in the UNESCO representative list of human intangible cultural heritage. So far, 43 projects in China have been listed in UNESCO’s intangible cultural heritage list, ranking first in the world! Who are the 43 World Intangible Heritage Sites? Come and find out ↓↓↓

List of representative works of human intangible cultural heritage (35)

Selected year: 2022

Traditional tea processing techniques and their associated social practices in China

Tea flourished in the Tang Dynasty and flourished in the Song Dynasty. China is the earliest country in the world to plant and make tea. The traditional tea-making skills and related customs in China are related to the knowledge, skills and practice of tea garden management, tea picking, hand-made tea, and tea drinking and sharing.

Selected year: 2008

Kunqu opera

Kunqu Opera is one of the oldest existing operas in China, which originated in the Ming Dynasty. The singing of Kunqu Opera has a strong artistic quality, which has a great influence on all modern dramas in China.

Guqin art

Guqin is the most representative solo instrument in China, which has a history of more than 3,000 years in China. Guqin has seven strings and thirteen emblems, and players can play four octaves through ten different plucking methods.

Xinjiang Uygur Muqam Art

"Xinjiang Uygur Muqam" is the general name of all kinds of Muqam that spread in various Uygur inhabited areas in Xinjiang, China, and it is a large-scale comprehensive art form integrating singing, dancing and music.

Mongolian long-tune folk songs (jointly declared by China and Mongolia)

Long tune is a lyric song, which consists of 32 melodies with a lot of decorative sounds. It praises beautiful grasslands, mountains and rivers, praises parents’ love and close friendship, and expresses people’s thinking about their fate.

Selected year: 2009

China seal cutting

China seal cutting is a unique engraving art with stone as the main material, carving knife as the tool and Chinese characters as the representation.

China’s woodblock printing technology

Block printing technology is a special technology that uses a knife to carve characters or patterns on a wooden board, and then uses ink, paper, silk and other materials to print and bind books. It has a history of more than 1,300 years, which has created a precedent for human copying technology.

China’s calligraphy

China’s calligraphy developed with the emergence and evolution of Chinese characters. After more than 3000 years, it has become a representative symbol of China culture.

Chinese paper cutting

Chinese paper-cutting is a folk art that uses scissors or a carving knife to cut and carve patterns on paper to decorate life or cooperate with other folk activities.

China traditional wooden structure building construction skills.

China’s traditional wooden building construction technology is a building construction technology system with wood as the main building material, tenon and mortise as the main combination method, and modular system as the scale design and processing production means, which has been extended for more than 7,000 years.

Craftsmanship of nanjing yunjin brocade

Craftsmanship of nanjing yunjin brocade has the tradition of royal weaving in China and is the representative of the highest level of brocade skills in China.

Dragon Boat Festival

Dragon Boat Festival is a traditional festival in China, which falls on the fifth day of the fifth lunar month. It has a history of more than 2,500 years. The festival custom of driving away drugs and evil spirits has spawned a variety of folk activities such as sacrifice, entertainment and health care.

China Korean Nongle Dance

China Korean agricultural music dance is a folk performing art which integrates performance, singing and dancing, reflecting the traditional farming production and life, offering sacrifices to pray for blessings and celebrating the harvest. Dance has the characteristics of ecology, simplicity, roughness and harmony.

Mazu believes in customs

Mazu is the most influential patron saint of navigation in China. Mazu’s belief in customs is a folk culture with the spirit of worshiping and praising Mazu’s virtue, doing good deeds and loving love as its core, Mazu Palace and Temple as its main activity place, and customs and temple fairs as its manifestations.

Mongolian Humai Singing Art

Humai is a magical singing art created by Mongolians: a singer sings two parts at the same time with his own vocal organs. Among the folk songs of various nationalities in China, it is unique.

Nanyin

Nanyin is a performing art that combines singing and playing, and it is one of the oldest existing music types in China. Nanyin is sung in Quanzhou dialect, mainly with pipa, flute, erhan, sanxian, clapper and other musical instruments, and the music is written with five Chinese characters of "six thoughts and one thought".

Regong art

Regong art mainly refers to Thangka, murals, pile embroidery, sculpture and other Buddhist plastic arts, and is an important art school of Tibetan Buddhism. Its content is mainly Buddhist native stories, historical figures and myths and legends.

China traditional mulberry silk weaving skills.

Sericulture is a great invention of China and a cultural symbol of Chinese national identity. This heritage includes the production techniques in the whole process of planting mulberry, sericulture, reeling, dyeing and silk weaving, the tools and looms used in the process, the silk products such as silk, gauze and so on, and related folk activities.

Traditional firing techniques of Longquan celadon

The traditional firing technique of Longquan celadon is a traditional handicraft with the characteristics of production, skill and artistry. It has a history of more than 1700 years.

Traditional production techniques of rice paper

Papermaking is one of the four great inventions in ancient China. Xuan paper is an outstanding representative of traditional handmade paper, which has the characteristics of soft texture, no decay and so on.

Xi’ an drum music

Drum music in Xi ‘an is a kind of drum music that spreads in Xi ‘an and its surrounding areas. Band organization is divided into percussion instruments and melody instruments, and the playing forms are divided into sitting music and playing music.

Cantonese opera

Cantonese opera is a drama style sung in Cantonese, with a history of more than 300 years. It has absorbed various musical and dramatic elements, and perfectly combined the bangzi and Erhuang tune with the phonology of Cantonese dialect.

Flowers

Hua ‘er was born in the early Ming Dynasty (around 1368 AD), and it is a folk song shared by Han, Hui, Tibetan, Dongxiang, Baoan, Salar, Tu, Yugur and Mongolians in the three provinces (regions) of northwest China. Named for comparing women to flowers in the lyrics.

Manas

The Kirgiz epic Manas, which has been sung for thousands of years, is one of China’s three major epics, among which the most famous is the genealogical legendary narrative of Manas and its eight generations of heroes, with a length of 236,000 lines, which is the "encyclopedia" of Kirgiz’s outstanding creation and oral inheritance.

Gesa (Si) er

Gesar is a grand narrative about the sacred achievements of Gesar, an ancient Tibetan hero. The epic tells the heroic story of King Gelsall who devoted himself to the lower world to save the living beings, led the people of Lingguo to subdue demons, suppress the strong and help the weak, resettle the Three Realms, complete the human mission, and finally return to heaven.

Dong people’s big songs

Dong folk songs are the general name of Dong folk multi-voice folk songs without accompaniment and command. Including voice songs, narrative songs, children’s songs, stepping on the hall songs and blocking the road songs.

Tibetan opera

Tibetan opera is a Tibetan drama with masks and songs and dances, which was formed in the 14th century and spread in the Qinghai-Tibet Plateau. The repertoire is eight traditional Tibetan operas, most of which are myths and legends in Buddhist scriptures to persuade the good and punish the evil.

Selected year: 2010

Chinese medicine acupuncture

Acupuncture is a medical method in traditional Chinese medicine. Acupuncture theory holds that the human body is like a small universe connected by various meridians. By physically stimulating the meridians, it is possible to promote the self-regulation function of the human body and bring health to patients.

Beijing Opera

Beijing opera is a performing art that combines singing, reading, doing and playing. The singing and reading of Peking Opera mainly use Beijing dialect, while the script is written according to a series of strict rules that pay attention to form and rhythm.

Selected year: 2011

Chinese shadow puppetry

Chinese shadow play is a kind of drama form with colorful shadow puppets made of leather or paper, accompanied by music and singing. Shadow puppeteers manipulate shadow puppets with wooden poles behind the scenes, and create dynamic images by shining light on translucent curtains.

Selected year: 2013

China’s Abacus Calculation —— Knowledge and Practice of Mathematical Calculation with Abacus

Abacus calculation is a method of digital calculation with abacus as a tool. Abacus is a great invention of the ancestors of the Chinese nation, and its contribution in the history of the development of the Chinese nation is no less than any of the "four great inventions".

Selected year: 2016

Twenty-four solar terms-Chinese’s time knowledge system formed by observing the annual movement of the sun and its practice

"Twenty-four solar terms" is a knowledge system and social practice formed by Chinese by observing the annual movement of the sun and recognizing the changing laws of seasons, climate and phenology in a year. The ancients in China divided the annual movement track of the sun into 24 equal parts, and each equal part was a "solar term", collectively called "24 solar terms".

Selected year: 2018

Tibetan Medicine Bath Method —— Knowledge and Practice of Life and Health and Disease Prevention of Tibetans in China

Tibetan medicine bath method, called "soaking" in Tibetan, is the traditional knowledge and practice of Tibetan people to adjust their physical and mental balance and realize life health and disease prevention by bathing in natural hot springs or water juice or steam boiled by drugs under the guidance of the life view of "five sources" of earth, water, fire, wind and air and the health view of "three causes" of Long, Chiba and Bacon.

Selected year: 2020

Tai Ji Chuan

Tai Ji Chuan is a traditional sports practice based on China’s traditional philosophy and concept of health preservation, which is based on the cycle of Yin and Yang and the unity of man and nature. This heritage project pays attention to the cultivation of ideas and the adjustment of breathing, with five steps and eight methods as the core movements, and routines, exercises and pushing hands as the movement forms.

"Sending the King’s Boat —— Ceremony and Related Practice of Sustainable Contact between Man and the Ocean" (Joint Declaration of China and Malaysia)

Sending the king’s boat is a ceremony widely spread in Minnan, China and the coastal areas of Malacca, Malaysia, which has both commonness and locality. In southern Fujian, it is mostly held every three or four years when the northeast season is windy in autumn; In Malacca, it is mostly held in the leap year of the lunar calendar and on the auspicious day in the dry season. The ceremony lasted for several days or months.

List of intangible cultural heritage in urgent need of protection (7)

Selected year: 2009

Qiang nian

The Year of the Qiang is a traditional festival of the Qiang people in Sichuan, China Province, and it is celebrated on the first day of the tenth lunar month every year.

Li nationality’s traditional spinning, dyeing, weaving and embroidery skills

The traditional spinning, dyeing, weaving and embroidery technique of Li nationality is a kind of textile technique created by Li nationality women in Hainan, China Province. It integrates spinning, dyeing, weaving and embroidery, and uses cotton thread, hemp thread and other fibers to make clothes and other daily necessities.

Traditional construction techniques of China wooden arch bridge

The construction technology of China wooden arch bridge with beams is to use log materials, traditional wooden building tools and manual techniques, and use core technologies such as "beam-making" to connect with tenons and mortises to form an extremely stable arch bridge technology system.

Selected year: 2010

Maxi Refu

Maixi Refu is the most important bearer of the cultural tradition of the Uygur people. The complete activities of Maixi Refu include a series of rich customs and performing arts, such as music, dance, drama, folk art, acrobatics, oral literature, diet and games.

Manufacturing technology of China watertight compartment blessing boat.

The manufacturing technology of watertight compartment was developed in Fujian Province in the south of China, which made it possible to build a seagoing vessel with watertight compartment. The key technologies that need to be applied in the manufacture of this sailboat are: tenon joint and stern joint, which refer to the tongue-and-groove joint of wooden boards respectively, and the technology of using ramie, tung oil and lime as blocking materials for the joints between wooden boards.

Chinese movable type printing

China’s wood movable type printing is one of the oldest printing technologies in the world, and Ruian, Zhejiang Province has maintained this technology, where it is still used to compile genealogy. Men are trained to carve Chinese characters and print them after engraving, word picking and typesetting.

Selected year: 2011

Imakan of Hezhe nationality

Imakan is an important part of Hezhe people’s world outlook and historical memory in northeast China. Imakan narrates in Hezhen language, in the form of poetry and prose, and consists of many independent tracks, describing tribal alliances and wars, including the story of Hezhen hero beat the devil and invaders.

List of Excellent Practices (1)

Selected year: 2012

Strategy for training coming generations of Fujian puppetry practitioners

Fujian puppet show is an outstanding representative of China’s puppet performance art, and its main performance forms are marionette and palm puppet. Since the 1980s, with the changes in production and lifestyle, and the complicated performance techniques of Fujian puppet shows, young people’s willingness to learn and inherit has declined, and there are few successors to Fujian puppet shows. Since 2006, relevant communities, groups and representative inheritors have formulated the "Fujian Puppet Show Successor Training Plan" from 2008 to 2020 around the main goal of cultivating inheritors. Through systematic professional training, cultivate a new generation of puppet show practitioners and improve the survival ability of Fujian puppet show; Through holistic protection, we can cultivate potential puppet show practitioners and appreciators, improve the living environment of Fujian puppet show, and effectively promote the protection and inheritance of Fujian puppet show.

(Editing Zhang Xiaoqing’s graphic materials are all from China Intangible Cultural Heritage Network)

Jingshang Sinotrans Zi [2022] No.32

Bureau of Commerce of each district, Bureau of Commerce and Finance of Development Zone, and relevant units:

　　According to the relevant provisions of the Notice of the Ministry of Finance and the Ministry of Commerce on Printing and Distributing the Measures for the Administration of Special Funds for Foreign Trade and Economic Development (Cai Jian [2022] No.3, hereinafter referred to as the Measures for Funds) and the Notice of the General Office of the Ministry of Finance and the General Office of the Ministry of Commerce on the Key Work of Special Funds for Foreign Trade and Economic Development in 2022 (Cai Ban Jian [2022] No.37), in order to do a good job in the declaration of import discount projects in 2022, we will now make relevant statements.

　　I. Basic information

　　The import discount is subject to catalog management, and this import discount declaration is based on the Catalogue of Technologies and Products Encouraged to Import (2016 Edition) issued by the National Development and Reform Commission, the Ministry of Finance and the Ministry of Commerce. The catalogue includes three parts: advanced technology encouraged to import, important equipment encouraged to import and key industries encouraged to develop. The Service Trade Department of our bureau is responsible for encouraging the introduction of advanced technology, and the Foreign Trade Operation Department is responsible for encouraging the import of important equipment and encouraging the development of key industries.

　　Second, the enterprise application conditions

　　(1) Import the products listed in the Catalogue of Technologies and Products Encouraged to Import (2016 Edition) issued by the National Development and Reform Commission, the Ministry of Finance and the Ministry of Commerce (hereinafter referred to as the Catalogue) and the new edition of the Catalogue issued according to the changes of the situation (excluding old products), or import the technologies listed in the Catalogue from non-affiliated enterprises.

　　(2) The applicant enterprise for imported products shall be the consuming and using unit on the Import Goods Declaration Form; The applicant for technology import shall be the technology user on the Registration Certificate of Technology Import Contract.

　　(3) The import declaration of imported products shall be completed from July 1, 2021 to June 30, 2022 (subject to the customs clearance date); The imported technology shall execute the contract from July 1, 2021 to June 30, 2022, and obtain the foreign exchange payment certificate issued by the bank.

　　(four) the technology import contract does not contain provisions that violate the regulations of People’s Republic of China (PRC) Municipality on the administration of technology import and export (the State Council DecreeNo. 331st).

　　(5) The equipment imported under "Key Industries to Encourage Development" in the Catalogue is not included in the Catalogue of Imported Commodities Not Exempted from Tax for Domestic Investment Projects (Adjusted in 2012) (Announcement No.83 of Ministry of Finance, National Development and Reform Commission, General Administration of Customs and State Taxation Administration of The People’s Republic of China, 2012).

　　(6) The total amount of imported products and technologies meeting the above conditions shall not be less than 500,000 US dollars.

　　(7) According to the relevant requirements, central enterprises in Beijing (all enterprises affiliated to central enterprises shall be declared through the Central Enterprise Group) shall be declared through their central departments (institutions), and the Beijing Municipal Bureau of Commerce will no longer accept them.

　　Third, the application materials

　　(1) Application documents signed by the legal representative of the enterprise (Annex 1), including: basic information of the enterprise, import purposes, expected benefits, project performance objectives (completion of work and objectives), etc.

　　(2) Notes on the Declaration of Import Discount Matters in 2022 (Annex 2) and electronic data.

　　(3) Business license of the enterprise (photocopy).

　　(4) Application Form for Import Discount Matters in 2022 (Annex 3) and electronic data.

　　(5) Import product order contract or technology import contract (photocopy, Chinese translation is required for non-Chinese contracts).

　　(six) imported products, the need to provide the "People’s Republic of China (PRC) Customs Import Goods Declaration Form" (copy or printed copy of the enterprise retained).

　　(7) If technology is imported, it is required to provide the Registration Certificate of Technology Import Contract, Data Sheet of Technology Import Contract and the foreign exchange payment certificate (photocopy) issued by the bank indicating the technology import contract number. If the technology user is inconsistent with the foreign exchange payment unit, the agency contract of both parties shall be provided. The amount of technology import refers to the amount of technology fees paid for importing technologies in the Catalogue from non-affiliated enterprises through transfer, licensing, commissioned development, cooperative development, technical consultation, etc. (excluding equipment, training, debugging, travel and other expenses, excluding technology import fees paid in proportion based on annual sales and profits). Please indicate the technology import contract number, technology name and the amount of foreign exchange payment that meets the discount conditions on the payment voucher.

　　(8) To import the equipment under "key industries to encourage development", it is necessary to provide the Confirmation of Domestic and Foreign-funded Projects Encouraged by the State (or the Confirmation Notice of Applicable Encouraged Industrial Policies issued by the Customs, including the list and photocopy of imported equipment attached to the confirmation letter or notice), the Certificate of Tax Exemption for Import and Export Goods (photocopy) and the Import Goods Declaration Form (photocopy). If the tax exemption certificate cannot be obtained because the tariff is zero, the tax exemption certificate may not be submitted, but the relevant situation shall be explained in the application report, and the certification materials that the relevant goods are zero tariff shall be submitted; Belonging to the "National Engineering (Technology) Research Center, National Engineering Laboratory, State-recognized Enterprise Technology Center, Key Laboratory, High-tech Entrepreneurship Service Center, New Product Development and Design Center, Scientific Research Pilot Base and Experimental Base Construction" in the third part of the Catalogue, it is not necessary to submit the Confirmation of Domestic and Foreign Projects Encouraged by the State, but it must be submitted to the Ministry of Science and Technology, the National Development and Reform Commission and other departments.

　　(nine) if the important equipment has technical parameters, it is necessary to provide import contracts or product manuals and other relevant certification materials that list the technical parameters of the goods.

　　(ten) the introduction of technology should explain whether it is introduced from affiliated enterprises, and the relevant information should be explained with supporting materials if the enterprise is renamed.

　　The above materials must be stamped with the official seal of the enterprise.

　　Iv. Work progress and reporting time

　　(1) Submit written materials on site from July 25th to July 29th, 2022 (in duplicate).

　　(2) Check the original materials on site from August 8 to August 12, 2022, and submit the bound paper materials (with page numbers) in triplicate and electronic data (submitted by USB flash drive).

　　V. Place and method of submitting materials

　　Venue: The application materials shall be delivered to the conference room on the second floor of Annex 6, Xili South District, Chaoyang Park, Chaoyang District, Beijing.

　　Method: In order to do a good job in epidemic prevention and control and avoid the possible infection risk caused by crowd gathering, this year’s import discount materials are submitted by appointment system. The reporting enterprise shall complete the telephone appointment from July 20th to July 22nd (9:00-18:00), submit the written materials at the site according to the agreed time, and will not accept the appointment afterwards. Each unit shall send at most one person to the site to declare the materials. Please leave the name and mobile phone number of the person when making an appointment.

　　Appointment telephone number for submission of materials: 17610520360

　　Business consultation telephone (product): 55579519

　　Business consultation telephone number (technology): 55579493

　　VI. Training and other arrangements

　　In order to do a good job in the declaration of import discount projects in 2022, the Municipal Bureau of Commerce is scheduled to hold a training meeting on the project declaration process from 15: 00 to 16: 30 on Monday, July 18, and enterprises that intend to declare can voluntarily participate. The training adopts online conference (Tencent conference number: 823614617), and participating enterprises need to download the "Tencent Conference" client in advance.

　　In order to facilitate communication and receive notification information, enterprises applying for intention can scan the QR code (Annex 4) and join the "Beijing 2022 Import Discount Declaration" WeChat group. Please note "enterprise name+contact person name" for enterprises joining the group.

　　I hereby inform you.

Beijing Municipal Bureau of Commerce　　　　

July 13th, 2022　　

Male nannies are still a minority in the market.

　　Near the end of the year, the topic of "Chinese New Year nanny’s daily salary exceeds that of 500 yuan" has attracted attention. According to media reports, during the Spring Festival in 2020, the price of domestic service personnel will all rise, and the daily salary of full-time nannies will also start in 300 yuan, and the highest can reach above 500 yuan.

　　Every year when the Spring Festival is approaching, the salary and shortage of nannies will cause heated discussion. Families who need to hire nannies also say that it is not easy to find a suitable nanny during the Chinese New Year.

　　So, what’s the situation of Hangzhou nanny market this year? Qianjiang evening news recently visited the domestic service market in Zhaohui, Hangzhou, and chatted with the agents and aunts.

　　"Aunt in short supply? You see, we sit here every day waiting for the aunt hired by the employer. " Zhang Fengjuan, head of Chengwang Home Economics Service Department in Hangzhou Zhaohui Home Economics Service Market, said that it is now more difficult to match the needs of both parties: employers have their own set of standards for choosing people; When aunts take jobs, most of them have to weigh various factors such as labor remuneration and service intensity.

　　3,300 yuan to chat for a month, no one did it.

　　"Where are you from?" "How old?" "Going back to your hometown in the New Year?" … … On December 25th, Mr. Wang, a 50-year-old Hangzhou native, wanted to find a nanny for his 75-year-old mother. "My mother lives in an apartment for the elderly, and she is taken care of for eating and washing, and her actions are fairly comfortable. She just wants to find someone to talk with her and look after her at night."

　　He soon surrounded a circle of aunts, but none of them had the will to take this job.

　　"The monthly salary is 3,300 yuan, and the Chinese New Year is coming soon. Such a price will definitely not be found." An aunt from the Northeast is very honest and frank: Even though this kind of work is relatively easy, their main purpose is to make money. "Without money, everything else is useless.".

　　At 3: 00 pm, there are few employers looking for domestic service, and aunts sit and chat in twos and threes, and also share some recruitment news. "I just came to an employer and lived in a five-story villa. It costs 6,000 yuan a month. Will you do it?" An aunt asked. Soon, many aunts around began to discuss. Some people estimated that "cleaning the fifth floor, cooking and looking after the children are very tired and unbearable." Someone bluntly said, "Such a heavy job is not cost-effective."

　　Within a few hours of the reporter’s squatting in the domestic service center, some employers came one after another, but few of them actually signed the contract. Mr. Huang, 51, wanted to find a live-in nanny for the elderly at home. He went around the market several times and didn’t find the right one. He said, "During the Chinese New Year, my salary will definitely go up, and I can accept it, but the main reason is that there is no eye fate. Choosing a nanny depends on the eye fate."

　　It’s hard to find a job after 60.

　　Aunt Han from Jiangxi has been waiting in the market for several days, but she hasn’t waited for her employer. She said, the main reason is my age. "I am 62 years old this year. Many employers will think I am too old, afraid that I will not do things neatly, and I am afraid that I will have physical problems at home and cannot afford this responsibility."

　　"Of course, people in their forties are the most popular," Aunt Han observed some aunts who were negotiating with their employers, and was a little unconvinced. "They are confident, mainly young, but many of them are not as experienced as me."

　　During the interview, Aunt Han told reporters not to always write "nanny shortage". "Look, where is the shortage? Aren’t they all waiting aunts?" She recalled that last year, the market suddenly flooded into a group of "unfamiliar faces" aunts. These aunts said that they saw on TV that Hangzhou was "aunt shortage" and their wages were high, so they ran from Wenzhou and Taizhou. "As a result, I found that this was not the case at all and went back the next day."

　　Aunt Han also complained that the arrival of a large number of "young" aunts would take away her few opportunities.

　　Male nanny wronged: I can cook and wash clothes.

　　"Where did you come from?" "I’m not doing it at home now. I’m a security guard."

　　"Why did you come here?"

　　"Being a nanny again."

　　An aunt sat next to Lao Zhang and chatted with him. Lao Zhang, 51, was the only male candidate in the market that day. He changed from security guard because he felt that the income from work in the domestic industry was stable. "There are few cases of wage arrears and family warmth."

　　As early as 2006, Lao Zhang entered the domestic industry. Later, because the acceptance of male nannies decreased, he began to find other jobs.

　　Lao Zhang said that most families don’t accept male nannies. On the one hand, many male nannies smoke and drink, causing dissatisfaction among the elderly in the family, "ruining the atmosphere." In addition, male nannies spend more on eating and drinking at home. "For example, if a woman eats a bowl of rice, we may have to eat two bowls, which is a bit too much for the average family."

　　The aunt on the side took the conversation. "The male nanny is completely uncompetitive compared with us. Cleaning, washing clothes and cooking are all done well by women. "

　　Lao Zhang was anxious. "I can cook and wash clothes as well, and I am stronger than you."

　　Lao Zhang decided to try again while the Chinese New Year was coming. He said, "It’s best to find a long-term nanny. If not, you can be a short-term babysitter with high salary."

　　Aunties gave him advice. Generally, after the twentieth day of the twelfth lunar month, there will be a "replacement tide", and many nannies who used to live at home may come out to be substitutes. The salary depends on the workload of the new employer’s family, usually 300-500 yuan a day.

　　Lao Zhang immediately asked after listening, "Is 500 a day to see the elderly or children?" "Children, of course."

　　Lao Zhang gave a cry and stopped talking. He knows that the elderly who are seriously ill or fat are more willing to choose him.

　　Chinese New Year red envelopes test the employment relationship best.

　　In Zhaohui domestic service market, we know that during the Chinese New Year, most aunts hope that their employers can double their wages or give them a big red envelope. Many aunts said that employers usually give them a salary increase, red envelopes and clothes during the Spring Festival. If some employers don’t want to, they may quit their jobs or jump ship when the Spring Festival approaches, and come to the domestic market to see new opportunities.

　　"But most aunts still go home during the Chinese New Year, and there are indeed a few substitutes." An aunt said.

　　Aunt Ke, who is going to stay in Hangzhou for the Spring Festival this year, said that the salary for the Spring Festival is expected to be one day in 400 yuan. However, she said that domestic service agents are unwilling to raise prices too high. "They are afraid of disrupting the market, and they are afraid that the asking price will be too high and the signing rate will be reduced, which will affect their commission." So sometimes, she will make two preparations, talk to her employer herself, or go to the intermediary to sign an agreement. "Without an agreement, there is no guarantee."

　　At present, Aunt Ke has a potential employer and is very satisfied with her, but Aunt Ke still wants to wait and see. "Because I need to take care of an old man with a stroke." She said that most aunts are more willing to take care of children, and their wages are relatively high. Generally, they spend more than 6,000 yuan a month to look after children and 4,000-5,000 yuan to take care of the elderly.

　　In the domestic service market, we also found that most of them came from older aunts and employers.

　　"Now many post-80s and post-90s couples are looking for domestic service, and they prefer to find it on various Internet platforms, which will also divert some customers. Most of the people who come to the housekeeping center to find their aunts are elderly people. " Zhang Fengjuan said that now, some young aunts will also choose to call the domestic service platform online.

　　Should I give the nanny a red envelope during the Spring Festival? (Reporter Chen Xi)

　　CCTV News:Today is "national love teeth day". According to the results of the third national oral epidemiological survey, more than 85% of adults in China suffer from periodontal diseases, which are closely related to the health of other organs in the whole body.

　　Periodontal diseases are related to organ health.

　　Periodontal diseases mainly include gingivitis and periodontitis. It is a common oral disease that gingiva and tissues around teeth are inflamed and destroyed under the action of dental plaque, which leads to tooth loosening and falling off.

　　The oral cavity is the entrance of respiratory tract and digestive tract. Periodontal diseases not only harm the oral cavity, but also are closely related to the whole health. When periodontal diseases occur, a large number of bacteria gather on the tooth surface and periodontal area, forming erosive ulcer surface. When a large number of bacteria accumulate on the ulcerated surface, daily chewing activities can make bacteria and toxic products enter the blood circulation, increasing the risk of systemic diseases.

　　Luan Qingxian, director of the Department of Periodontology at Peking University Stomatological Hospital, pointed out that periodontal diseases are linked to the heart, the brain, the lungs, the stomach and the next generation. For example, research now believes that if there are inflammatory factors in the blood, it will increase the prevalence of diabetes. Other studies have shown that the prevalence of cardiovascular and cerebrovascular diseases in patients with periodontal diseases will also increase.

　　Prevention of periodontal diseases and avoidance of obsolescence

　　The tooth loss rate of the elderly aged 65 to 74 in China is as high as 86%, while 10% of the elderly have no teeth at all. Experts remind that missing teeth will add a lot of burden to the digestive system and cannot be underestimated.

　　Tooth loosening is a slow process of physiological change, and the most effective way to avoid tooth loss is to prevent periodontal disease. Symptoms of periodontal disease include gingival bleeding, gingival swelling, pain, etc., which can cause teeth to loosen or even fall off in severe cases. Plaque and tartar are the chief culprit of periodontal disease, and adults should wash their teeth once a year.

　　Some people say that it is a natural law for people to lose their teeth when they are old, and there is no need to repair them. The doctor reminded that if the teeth are missing, the balance of the whole mouth will be disturbed. If not repaired in time, the rest of the teeth will be tilted, displaced and periodontal damage will be caused.

　　Children and pregnant women should pay special attention to oral health.

　　Special attention should be paid to the oral health of children and pregnant women. Children’s oral examination should start within 6 months after the first deciduous tooth erupts, once every six months. The oral health of pregnant women is not only related to their own health, but also affects the health of the fetus, which may lead to premature delivery and low birth weight infants. Moreover, during pregnancy, due to factors such as hormonal changes in the body and decreased immunity, pregnant women are particularly prone to cause dental and gingival lesions.

　　Small floss is a good helper for tooth cleaning.

　　A large number of studies have confirmed that although periodontal disease is the most prevalent oral disease, it can be prevented and cured. In addition to brushing our teeth on weekdays, there is also a small tool that can help us clean the plaque between our teeth, and that is dental floss.

　　The doctor said that brushing teeth with a toothbrush can only clean 70% of teeth, and the other 30% is the gap between teeth. Many oral diseases are caused by the uncleanness of the gap between teeth. Flossing can effectively remove residual food, soft tartar and clean dental plaque.

　　How to use dental floss stick correctly?

　　For patients who floss for the first time, a dental floss stick is a good choice. When you use the dental floss stick, the dental floss is directed at the gap between teeth, and gently slides the gap between teeth by horizontal pulling and oblique pulling, so that the dental floss is "C"-shaped, and then it is pulled up and down for four to six times, and then the other side, which is also the "C"-shaped, is cleaned, and then it is pulled up and down for four to six times, and finally the dental floss is slowly pulled out from the gap.

　　Experts emphasize that dental floss cannot be reused. Some friends reuse the same dental floss for convenience, which is very undesirable. Because dental floss will carry a lot of germs after cleaning teeth, and these germs can’t be washed clean with water. Frequent use may bring more bacteria to teeth, so be sure to pay attention!

　　There is no harm in using dental floss. As long as you master the correct use method, don’t use too much force to avoid damaging your gums, you can floss once or twice a day.

　　Can you really brush your teeth?

　　Do you want to brush your teeth if it bleeds? Can soft bristles brush away dirt from teeth? Xiaobian combed the eight misunderstandings about brushing your teeth and poked pictures to learn how to brush your teeth correctly!

　

　

　

　

　

　

　

Special feature of 1905 film network Before the Double Eleven, domestic fans had entered the carnival mode.On October 29th, 2020, at the 20th National Cinema Domestic New Film Promotion Conference, more than 500 people gathered in Hengdian, Zhejiang, including 51 cinemas, over 50 film investment companies, distributors and production representatives. China Film, Huaxia, Bona, Wanda, Huayi and other upstream production companies have collectively promoted more than 100 outstanding domestic new films (including co-productions).

According to the information such as the promotion film list and the preparatory film list released by major film and television companies, it is accumulated that 262 new films will have or are expected to land in the cinema market in 2021. Among them, 242 films were made in China, accounting for 92.37% of the total, and 20 films were co-productions.

Movie Channel Merging Media, together with 1905 Movie Network and M Big Data, released the "2021 Cinema Foresight Report", and made a comprehensive inventory of 262 new films from the perspectives of film types, themes, IP and production companies.

What secrets will this report tell the audience behind the new film?

New films: plot, animation and comedy account for the largest proportion.

262 new films to be released, what state the progress bar is in, is one of the most concerned issues for the audience.

Judging from the current shooting progress, after rough statistics, there are 68 films in the preparatory stage, 112 films in the shooting and production stage, and 68 films have been completed and finalized. The proportion of new films in the shooting and production stage is the largest, reaching 42.75% of the whole.

Among the films that have been booked, at the 20th National Cinema Domestic New Film Promotion Conference, three relay films were booked for the Spring Festival in 2021, which pushed the market sentiment to a climax. The three films just correspond to animation, comedy and plot types respectively, which is highly consistent with the portrait data of the new film types to be released.

After counting the main elements of 262 new films to be shown, it can be found that the film list types cover 26 categories. Among them, the number of films with plot elements is 101, accounting for 22.1%, ranking first in the film genre. Animation and comedy genre films followed closely, reaching 47 and 45 respectively, accounting for 17.9% and 17.1% of the total.

The number of new animated films ranks second, which is closely related to the national craze caused by high-quality domestic animated films such as, and so on. The comedy film has always been one of the evergreen films in the world.

In the top ten genre films, except for the above three, the number of new films about action, suspense, love, fantasy and crime is above 30. In recent years, these types of films have not run away from many box office dark horses and have a certain audience base.

With more new films being produced and finalized, China audiences will have more choices on the big screen in 2021. For cinema managers, these new films also indicate that cinema revenue has a basic guarantee.

New trend: the main melody melody is in full bloom.　

In recent years, with the right climate and the right people, the main melody blockbuster has become the new favorite of the market.

,,, etc., organically integrated the theme of the times with commercial value, achieving a double harvest of box office and word of mouth. Facts have proved that the main melody blockbuster skillfully integrated with commercial elements is easier to be digested and absorbed by the audience.

Among the new films to be released in 2021, the theme film is still an important part worthy of attention. Among these films, there are not only the 100th anniversary of the founding of the Party, but also the theme of resisting US aggression and aiding Korea, as well as red classic films.

In addition to reviewing history, many main melody films follow the pace of the times, praising China spirit and carrying forward patriotic feelings. For example, Shenzhou, which is the theme of manned spaceflight, Doctor China, which tells the story of China people’s war and epidemic, and China Flight Tester, which tells the story of China’s "test hero" Li Zhonghua, etc.

There are more realistic works based on real people and story prototypes. For example, the economic investigation film adapted from the "Fox Hunting Action" of the Ministry of Public Security, the story about the Jedi rescue of the frontier armed police, and the theme of getting rid of poverty.

Since the summer file in 2018, after the upsurge of realistic works was started, the strong sense of substitution and resonance of such works are more likely to give birth to box office dark horses and are more favored by capital. In 2021, the realistic works in the mainland film market are still at the peak of creation.

The market value of classic IP is reflected in many ways, such as sequels, adaptations and remakes. Among the 262 new films to be released, such as "manslaughter 2", etc., or will form a domestic series of films. Detective Chinatown 3, which will be released in the Spring Festival in 2021, has become one of the most concerned films in the sequel.

In addition, The Order of the Gods, which is based on the explosive mobile game IP, and The Blade of Wandering, which is based on the novel IP of Ghost Blowing Lights, remake the classic "Loyal Dog Eight Men" and other films with the same name, and it has been or is expected to be scheduled for 2021. Mature market awareness and broad audience base are important reasons why classic IP is popular in the market.

And Ne Zha have successively become explosions, which not only proves that the level of China’s film industry keeps pace with the times, but also sets off the creation fever of similar films.

At the 2020 China Science Fiction Conference held in early November, a set of data showed that under the leadership of The Wandering Earth, the total box office of domestic science fiction films reached 7,140.5 million in 2019, an increase of 212% compared with 2018. In the future, domestic sci-fi films such as "The Trilogy of Outer Space" directed by Chen Sicheng, supervised by Ning Hao and directed by Zhang Xiaobei will attract much attention from the market.

After the national cinemas resumed work in an orderly manner, the Opinions on Promoting the Development of Science Fiction Films jointly issued by the State Film Bureau and the China Association for Science and Technology strengthened the system construction of science fiction film production and personnel training from the policy level.

In terms of animated films, the new films to be released in the future are both young and adult. The series "Bears haunt", the permanent guest of the Spring Festival file, is the best choice for parents and children to watch movies. Adult-oriented animation, such as Phoenix and Nezha 2, adapted from classic fairy tales, shoulders the heavy responsibility of creating more glories for domestic animation.

It is worth mentioning that many domestic documentaries in the film list have international vision and production standards, and have certain box office potential. Directed by Jia Zhangke, after the world premiere of the special screening unit of the 70th Berlin International Film Festival, the audience gained online reputation. The first BRICS documentary film "Young People Without Borders" led by director Lu Chuan and the first water resource documentary "Zero Water Day" are all worthy of attention.

New mode: New and old film and television companies explore more cooperation modes.

The film and television circle has always been a vanity fair, and the participation of capital is indispensable behind many new films.

According to the current public information, a number of film and television production agencies have participated in the production and distribution of many new works. China Film Group, Huayi Brothers, WANDA CINEMAS and Enlight Media have exposed more than 20 reserved films respectively. By participating in the statistics of the number of projects, it is not difficult to find that the traditional film and television companies in the head are still in the leading echelon, and the new Internet film companies have grown into the backbone.

WANDA CINEMAS and Huayi Brothers, as the "big brothers" in the industry, give full play to the advantages of resource integration, not only participate in the production of Spring Festival blockbusters such as Detective Chinatown 3 and The Order of the Gods, but also actively arrange online film and television services such as online movies and online dramas, and actively explore more production modes and revenue channels.

As representatives of Internet film companies, Alibaba Pictures, Cat’s Eye Film and Tencent Film have an average reserve of more than 15 films. In the past, the lack of master explosion movies has become a collective pain point for Internet film companies. Nowadays, with the resources and experience accumulated by deep participation in publicity and development, these companies are testing water more and more times.

In addition to the increasing number of master works, the types in the company’s film list are more and more diversified, and both commercial expression and author’s style are equally important, which has become one of the content characteristics of Internet film companies participating in film production. At the beginning of the announcement, these companies took advantage of big data and launched more new models.

There are more and more cases in which traditional film companies and Internet film companies strengthen cooperation and give full play to their respective advantages. For example, among the producers of 1921, Fox Hunting, and other films, there are both traditional and Internet studios. In addition, new cross-border forces, represented by POP MART cultural and creative companies, are increasingly appearing among new film investors.

In the creation of big-screen works, besides the blessing of capital, the participation of filmmakers is essential. Judging from the creative information of new films to be released in 2021, many heavyweight filmmakers are active in all aspects of film creation.

Among them, three directors, Ning Hao, Jia Zhangke and Wu Ershan, all participated in the creation of five films. Their identity, from director to producer to actor, can be described as omnipotent. The change of different identities can also see the help of mature directors for the younger generation.

Among these films to be released, M Big Data sorts out the ten works that are most expected by netizens. Among them, six films, such as Detective Chinatown 3, Japanese and Korean, have been booked for the Spring Festival in 2021.

Detective Chinatown 3 ranks first in the M-fever list of 8 works scheduled for the Spring Festival next year, followed by The Rescue and Boonie Bears:The Wild Life. According to previous market experience, Detective Chinatown 3, which has the highest popularity before the screening, will lead the box office competition for the Spring Festival. Whether this film can break the curse of "the front runner can’t be the total box office champion" is worthy of attention.

In the future, 262 new films will meet the audience one after another. The collective booking and release of these new films indicates that the China film market has recovered its former vitality and will create more glories.

Original clinical nutrition network

Author: Plain dust-free

Postdoctoral fellow, University of California San Diego Cancer Center. Nutritionist, food safety engineer

Washington University in St Louis, graduate student in public health, pre-medical doctor. Doctor of Public Health from Louisiana State University Health Sciences Center, and Delta Omega Doctoral Award, one of the highest honors of American public health graduates. "China Clinical Nutrition Network" signed a dietitian

His main research interests are smoking cessation, alcohol withdrawal and marijuana withdrawal, nutrition and chronic diseases, and cancer prevention and control.

The article was first published in big doctor magazine, and was revised by the author and then pushed again.

China Clinical Nutrition Network has been authorized to reprint

Nutrients are various substances needed by the human body, which support the growth, development and normal physiological functions of the human body. The nutrients needed by the human body can be roughly divided into seven categories. In the past, we used 15 issues to introduce the physiological functions, excess and deficiency, food sources and hot topics of seven nutrients in detail.

The following is a brief summary of them and a link to introduce each nutrient in detail (click the title to enter directly):

General introduction

The first issue:

(Image from WeChat public platform public photo gallery)

1. protein

An important component of the human body, used to repair and build body tissues, is also the main component of enzymes, hormones and antibodies. Protein is rich in meat, eggs, beans, nuts and seeds.

Phase II:

(Image from WeChat public platform public photo gallery)

2. Fat

Provide energy for the body and help absorb fat-soluble vitamins. It includes saturated fat, monounsaturated fat and polyunsaturated fat. Healthy sources of fat include fish, nuts, seeds and olive oil.

The third issue:

(Image from WeChat public platform public photo gallery)

3. carbohydrates

The main energy source of the human body. It includes sugar, starch and fiber. Whole grains, vegetables, fruits and beans are good sources of carbohydrates.

Phase IV: Phase V:

(Image from WeChat public platform public photo gallery)

4. vitamins

Nutrients that the human body cannot make by itself and must obtain from food or supplements. They contribute to various physiological functions of the body, including immunity, vision and bone health. Vitamins are mainly obtained by eating fresh vegetables, fruits and whole grains.

Issue 6: Issue 7: Issue 8:

(Image from WeChat public platform public photo gallery)

5. minerals

It is very important for bone health, muscle function, nerve conduction and some biochemical reactions. Foods rich in minerals such as fresh vegetables, fruits, whole grains, nuts and seeds.

Issue 9: Issue 10: Issue 11: Issue 12:

(Image from WeChat public platform public photo gallery)

6. Dietary fiber

Although they are not absorbed by human body, they have many health benefits, including improving digestion, preventing constipation, controlling blood sugar and reducing the risk of heart disease. Dietary fiber mainly comes from vegetables, fruits, whole grains and beans.

Issue 13:

(Image from WeChat public platform public photo gallery)

7. Water

The main component of the human body is vital to the functions of all body systems, including temperature regulation, waste removal and transportation of nutrients.

Issue 14: Issue 15:

(Source: WeChat public platform public photo library)

Attachment: Nutritional catering

Why do people eat so many kinds of food every day? Because the body needs balanced nutrients! Every food contains different nutrients, so we need to take them from different foods. Generally, weight catering method and energy catering method can be used.

Issue 16: Issue 17: In the next series, we will use 10 issues to introduce nutrition and health in different life cycles, including the potential impact of newborn birth weight on health, eating and sleeping of babies, health and nutrition needs of children and adolescents, and nutrition needs and health management in early, middle and late adulthood. Regarding the life cycle, if you have any special topics you want to know, please leave a message.

Original title: "[Popular Science Nutrition] A summary of the seven nutrients and nutritional meals that the human body needs! 》

Read the original text

Percutaneous argon-helium knife treatment of liver cancer is one of the non-surgical treatment methods in recent years, which indicates that the treatment of liver cancer has entered a new stage of cryotherapy. Professor Yang Yongping, director of the Department of Hepatology and Medicine, Fifth Medical Center, General Hospital of Chinese People’s Liberation Army, shared the cryoablation treatment of liver cancer in the first multi-disciplinary cooperation forum of Anhui Province, and the platform of treating liver cancer with sincerity specially compiled the essence for readers.

Overview of liver cancer

In China, hepatocellular carcinoma (HCC) is the fifth largest malignant tumor and the second largest tumor-related death cause, with a five-year survival rate of only 14.2%. How to treat liver cancer scientifically and benefit the long-term survival of patients is an important clinical problem, and it is also the gold standard to measure the treatment level of medical units. In 2022, the updated guidelines for prognosis and treatment strategy of clinical liver cancer (BCLC) in Barcelona proposed that patients with HCC should be accurately evaluated individually. Doctors need to fully consider the scope and load of the tumor, the nutritional status and human performance of the patient, complications, age, etc., and formulate individualized treatment methods for the patient.

No matter what stage the patient is in, local ablation is an important treatment. At present, a variety of mature local ablation treatment techniques for liver cancer have been formed, including radiofrequency ablation, microwave ablation, cryoablation, irreversible electroporation (nano-knife) and so on.

Overview of cryoablation therapy

Cryoablation therapy has experienced a long development process. In 1800, James Arnott discovered that the mixture of ice and salt could delay the progress of breast cancer, uterine cancer and skin cancer. In 1950, liquid nitrogen and dry ice were used to treat different kinds of diseases, especially benign skin lesions. In 1961, Cooper and Le introduced the first automatic cryosurgical equipment, but it used liquid nitrogen as refrigerant, which had many complications and was only used in laparotomy. In the 1970s and 1980s, liquid nitrogen needle was used to treat prostate hypertrophy and prostate cancer, but the cryoablation technology was stagnant due to many complications. In the 1990s, intraoperative ultrasound monitoring of freezing process was used in surgery by scholars, and argon was studied as the refrigerant. In 1998, the third generation cryosurgery system (Argon-Helium cryosurgery system) came out in the United States, which used argon as the refrigerant and helium as the heat medium, bringing revolutionary progress to minimally invasive cryosurgery. In 2000, cryotherapy entered American medical insurance. In 2003, the World Congress of Targeted Cancer Therapy recommended cryoablation as the first choice for advanced lung cancer and liver cancer. In 2010, the standardized diagnosis and treatment of liver cancer promoted by the Health Planning Commission listed cryoablation as a local treatment for liver cancer. In 2016, after more than 10 years of unremitting efforts, Professor Yang Yongping’s team led the overall and comprehensive innovation and development of percutaneous cryoablation of liver cancer at home and abroad, changed the international prejudice on cryoablation of liver cancer, turned the small path into the big road, the irregular into the norm, and the unpopular into the hot spot.The technological innovation of cryoablation of liver cancer won the first prize of Beijing Science and Technology Progress Award. In 2018, 2019 and 2020, experts’ consensus on imaging-guided cryoablation for lung cancer, experts’ consensus on imaging-guided cryoablation for bone and soft tissue tumors, experts’ consensus on imaging-guided cryoablation for kidney cancer and experts’ consensus on imaging-guided cryoablation for liver cancer were released respectively. So far, NCCN, AASLD, APASL, EASL and other guidelines have recommended cryoablation for the treatment of primary liver cancer.

At present, the Department of Hepatology Medicine of the General Hospital of the Chinese People’s Liberation Army has become the largest medical center for treating liver tumors in the world last year, constantly exploring the innovation of cryoablation technology, adopting high-vacuum heat insulation technology, only destroying the tumor site without damaging the surgical path, and adopting multi-stage heat exchange technology, which makes the refrigerant utilization rate higher and the cooling rate faster, and it is easier to induce the frozen immune response of liver cancer patients, activate their own anti-tumor immunity and produce ectopic tumor inhibition.

Therapeutic mechanism and characteristics of cryoablation technology

The cryoablation area is composed of central coagulative necrosis area and peripheral tissue injury area with different degrees. The mechanism of rapid direct cell necrosis in the central area includes mechanical damage caused by ice crystal formation inside and outside the cell and osmotic damage caused by dehydration and rupture of the cell. Peripheral injury areas are mainly related to freezing-related secondary injuries, including hypoxia death of tumor tissue caused by blood embolism, apoptosis caused by reversible injury, and waterfall-like ectopic tumor suppression by stimulating immune regulation.

The characteristics of cryoablation technology include: ① clear treatment boundary, real-time monitoring under image, safe and reliable treatment; ② Treatment can stimulate human immunity and strengthen tumor treatment; ③ Physical therapy is non-toxic to human body, with extremely low side effects; ④ The treatment is painless, without general anesthesia and participation of anesthesiologists, and the treatment is convenient; ⑤ Not limited by the artificial pacemaker installed in the body; ⑥ Effective, suitable for lung cancer, liver cancer, kidney cancer, breast cancer, prostate cancer and other solid tumors.

In addition, ultrasound, CT, laparoscopy or intraoperative direct vision guidance can be used for cryoablation treatment, and the tumor position and the formation of ice hockey can be monitored in real time.

Current situation of percutaneous cryoablation of HCC

Before 2005, based on the previously reported clinical research results, there were many complications, such as bleeding, liver parenchyma frost crack, freezing shock, coagulation dysfunction and so on. International scholars were cautious about this technology. After 2005, percutaneous cryoablation for liver cancer has developed in China, especially with the publication of China’s continuous clinical summary and high-level evidence in the top international journal Hepatology. More and more clinical studies have confirmed that percutaneous cryoablation for liver cancer is safe and effective, and international scholars have a positive attitude.

Professor Yang Yongping’s team took the lead in conducting clinical research to determine the indications of liver cirrhosis-related HCC by percutaneous cryoablation. In this study, 1681 patients with liver cirrhosis-related HCC and 682 patients with advanced HCC were selected, and the indications and standards of complete cryoablation and selective cryoablation were established. It was proposed that the ablation volume of the target lesion should exceed 50% of the tumor volume or minimize the tumor load, relieve the symptoms caused by the tumor, improve the quality of life and prolong the survival time. The study also innovatively changed the percutaneous puncture to guide needle to locate the introduction of vascular sheath to solve the problem of bleeding after cryoablation, which has been cited by foreign counterparts for many times and suggested routine application.

Indications for complete cryoablation of liver cancer:

① The maximum diameter of a single tumor is less than 5 cm, or the number of tumors is less than 3, and the maximum diameter is less than 3 cm;

② Recurrence after surgical resection or other local treatment meets the conditions ①;

③ Child-Pugh A or B of liver function, bilirubin level ≤51.3μmol/L, or reaching this standard after medical treatment;

④ The blood coagulation function is good (prothrombin activity > 40%, platelet count > 30×109//L, using sheath hemostasis and packing system);

⑤ECOG PS ≤2；

⑥ Cirrhosis, including a history of chronic liver disease, with enlarged hepatic fissure/metacentric colon/esophageal varices/gastric varices/serrated liver surface, a history of upper gastrointestinal bleeding or ascites, and platelets < 100×109/L..

Indications for selective cryoablation of liver cancer:

① Single tumor with a maximum diameter of > 5cm or multiple tumors with a maximum diameter of > 3cm that cannot be surgically removed, regardless of whether there is tumor thrombus in portal vein;

② Child-Pugh A or B liver function classification, bilirubin level ≤51.3μmol/L or reaching the standard after medical treatment;

③ The blood coagulation function is good (prothrombin activity > 40%, platelet count > 30×109/L, using sheath hemostasis and packing system);

④QECOG PS ≤2；

⑤ Cirrhosis, including a history of chronic liver disease, with widened hepatic fissure/metacentric colon/esophageal varices/gastric varices/serrated liver surface, a history of upper gastrointestinal bleeding or ascites, and platelets < 100×109/L..

In addition, Professor Yang Yongping’s team innovatively established measures to prevent and treat complications of percutaneous cryoablation of hepatocellular carcinoma. In this study, 3321 patients were selected, and the measures of percutaneous cryoablation of liver cancer complications were established and verified (Table 1).

Table 1 Measures for Complications of Percutaneous Cryoablation of Liver Cancer

Moreover, the study has achieved encouraging clinical results, which increased the complete tumor ablation rate by 10.6%, reduced the local tumor recurrence rate by 30.3% in 5 years, and improved the 5-year survival rate by 16.6%.

Advantages of cryoablation in the treatment of hepatocellular carcinoma

Although cryoablation has distinct advantages over radiofrequency ablation (RFA), there is no RCT study in the past to directly compare the efficacy of ablation of liver cancer, especially the safety. Professor Yang Yongping’s team designed RCT study in five years to evaluate the efficacy and safety of percutaneous cryoablation and radiofrequency ablation of liver cancer. For the tumor, there were statistical differences in the local tumor progression rate between the two groups at 1, 2 and 3 years: 3%, 7% and 7% in the frozen group, respectively; The RF group was 9%, 11% and 11% respectively (P = 0.043). Subgroup analysis: For hepatocellular carcinoma with a diameter of > 3cm, cryoablation has a lower local tumor progression rate (cryoablation vs. RF: 7.7% vs. 18.2%, P=0.041). There was no statistical difference in the local tumor progression rate between 1-2cm (frozen vs. RF: 0% vs.2.4%, P=1.000) and 2.1-3.0cm (frozen vs. RF: 4.1%vs.7.1%, P=0.656). The results were published in Hepatology magazine and also in China.

Professor Yang Yongping’s team also confirmed that cryoablation of HCC can produce ectopic tumor inhibition, with the incidence of ectopic tumor inhibition of 6.3%, and the median survival time of patients with ectopic tumor inhibition was significantly prolonged. The mechanism is related to the down-regulation of PD-1/PD-L1 and regulatory T cells after ablation. In addition, argon-helium cryotherapy is effective for elderly HCC.

Unresolved problems in cryoablation of HCC

There are also many problems to be solved in the process of cryoablation for HCC in the future:

1. Does tumor cell ablation release specific tumor cell death signal?

2. How can freezing produce the best ratio of necrosis and apoptosis?

3. Are the cytokines released after freezing derived from tumor microenvironment or natural immune response, and what is their time sequence?

4. Will the functional essence and time sequence of antigen presenting cells that absorb necrotic tissue change after cryoablation?

5. What is the effect of cryoablation and absorption of necrotic tissue on the immunosuppressive function of the body? How to reduce the immunosuppression of the body?

Expert introduction

　

Professor Yang Yongping.

Chinese people’s liberation army general hospital No.5 medical center

Director, Department of Hepatology and Medicine, PLA General Hospital

Chief physician, professor, doctoral tutor

Silver Star of Science and Technology of the General Logistics Department, winner of special allowance of the State Council

Chairman of the Professional Committee of Liver Diseases of China Research Hospital Association

Director of China Hepatitis Foundation

Director of China Research Hospital Association

Vice Chairman of Liver Disease Professional Committee of Beijing Branch of Chinese Medical Association

Vice Chairman of Liver Disease Professional Committee of Beijing Society of Integrated Traditional Chinese and Western Medicine

Take the lead in the major special topics of the "Thirteenth Five-Year Plan and Twelfth Five-Year Plan" of the country, the key topics of the "Twelfth Five-Year Plan" of the army and the key topics of the Beijing Municipal Science and Technology Commission in integration of defense and civilian technologies; Won one national science and technology progress award, one first prize of Beijing science and technology progress award and six second prizes of military science and technology progress award.

Finishing/platform review/Professor Yang Yongping

This article is only for medical and health professionals to understand information, and does not represent the views of this platform. This information cannot replace professional medical guidance in any way, nor should it be regarded as medical advice. If the information is used for purposes other than understanding the information, the platform and the author shall not bear the relevant responsibilities.

　　CCTV News:According to the WeChat official account news released by Shanghai, the Shanghai Central Meteorological Observatory issued a blue rainstorm warning signal at 12: 30 on August 23rd, 2023: Due to the influence of strong precipitation clouds, it is predicted that there will be precipitation in parts of central and southern Shanghai with a cumulative rainfall of more than 50 mm in six hours before midnight today. Please pay attention to the prevention of urban waterlogging caused by heavy rainfall, and do a good job in drainage and waterlogging prevention in low-lying and flood-prone areas.

　　The yellow warning of lightning issued before is still high.

　　Defense guide:

　　1. Stop carrying out outdoor activities in open places.

　　2. Stop swimming in rivers, lakes and seas.

　　3. Stay away from trees, corners or places with prominent metal objects; Don’t hold objects with sharp metal corners in your hands or carry them on your shoulders.

　　Defense guide:

　　1. Citizens should prepare rain gear to ensure safety.

　　2, drivers pay attention to the road water.

　　Level Ⅳ response of flood prevention platform

　　According to the introduction of the Municipal Flood Control Office, the level IV (level IV) response of the city’s flood control stations started simultaneously.

　　Level 4 (IV) emergency response (blue)

Recently, the Hunan Provincial Health and Health Commission and the Hunan Provincial Department of Education issued the Notice on Strengthening the Prevention and Control of Key Infectious Diseases in Schools in Autumn and Winter. Infectious diseases on campus mainly spread through respiratory tract in autumn and winter, and some spread through digestive tract and contact, so it is easy to break out and spread in campus, so we should pay special attention to prevent the spread of infectious diseases.

According to the epidemic situation and incidence characteristics of infectious diseases, the school hospital has sorted out several knowledge of prevention and treatment of common infectious diseases in autumn and winter, please pay attention to it!

I. Influenza

(A) disease science

Influenza is an acute respiratory infection caused by influenza virus, and it is also a highly contagious and fast-spreading disease. Fog droplets ejected mainly by coughing or sneezing of infected people are transmitted to others through the air, and can also be infected by touching objects contaminated by influenza virus. The main clinical manifestations are high fever, headache, limb aches, fatigue and upper respiratory symptoms such as runny nose and cough. The infirm and the elderly are prone to pneumonia and other complications after infection.

The difference between influenza and common cold

(2) Prevention and control suggestions

1. Before the flu season, it is an effective way to prevent the flu by vaccinating high-risk groups and susceptible groups.

2. Reasonable arrangement of work and rest time: have a regular life, ensure adequate sleep, and avoid the decline of resistance caused by overwork, thus increasing the chance of illness.

3. Pay attention to personal hygiene: don’t spit everywhere, and cover your mouth and nose with a handkerchief or paper towel when sneezing or coughing.

Wash your hands frequently, and wash your hands immediately after touching respiratory secretions (such as after sneezing).

4. Open the window and ventilate several times a day to keep the indoor air fresh. During the high incidence of influenza, try not to go to crowded places with dirty air; You’d better wear a mask when you have to.

5. Effective prevention approaches: early detection, early reporting, early isolation and early treatment. Isolating patients is the most effective way to reduce transmission.

Second, cold diarrhea

(A) disease science

Infectious diarrhea refers to diarrhea caused by intestinal infection of pathogens such as bacteria, viruses, parasites or fungi. Its prevalence is wide, the incidence rate is high, it has the characteristics of acute onset, rapid spread and wide coverage, and it is an important disease that harms health. Mostly due to the intake of unclean diet (such as cold dishes, spoiled shrimp, crabs, drinks, etc.) and water, due to bacterial and viral pollution, coupled with some people’s bad hygienic eating habits, the disease enters the mouth. The clinical manifestation is diarrhea, which may be accompanied by abdominal pain, fever, nausea, vomiting and other symptoms. The stool characteristics often vary with different pathogens, and in severe cases, fever, dehydration, electrolyte disorder, abnormal renal function, acidosis, shock and so on may occur. Infectious diarrhea pathogens are excreted with excreta, which pollutes the environment, food and water sources and can cause outbreaks.

(2) Prevention and control suggestions

1. Pay attention to drinking water hygiene, don’t drink raw water, don’t eat cold and spoiled food, especially seafood and aquatic products.

2. Pay attention to food hygiene, don’t overeat, and eat less food that is easy to carry germs and be bitten by flies; Tableware should be disinfected, and raw and cooked tableware should be separated; Try to eat cooked food, and wash and peel raw fruits and vegetables.

3. Pay attention to personal hygiene, wash your hands before and after meals, do not defecate anywhere, do not dump garbage and dirt, and do not pollute water sources.

4. Report the patients with vomiting and diarrhea in time, and see a doctor as soon as possible for timely diagnosis and treatment.

Third, tuberculosis

(A) disease science

Tuberculosis, also known as "consumption", is a chronic infectious disease caused by the infection of Mycobacterium tuberculosis (commonly known as Mycobacterium tuberculosis). The part often invaded by Mycobacterium tuberculosis is the lung, which is called tuberculosis. The clinical manifestations of tuberculosis are various, and the early symptoms are mild and atypical. It is easy to be confused with other respiratory diseases, such as tracheitis and pneumonia, and it is often ignored, which leads to the delay of medical treatment. Cough, expectoration, hemoptysis or bloodshot sputum are the main symptoms of pulmonary tuberculosis. Most patients with pulmonary tuberculosis have hemoptysis with blood in sputum, and a few patients have hemoptysis with big mouth. In addition, chest tightness, chest pain, low fever in the afternoon, night sweats, general weakness, loss of appetite or weight loss are also common symptoms of tuberculosis.

(2) Prevention and control suggestions

1. Take tuberculosis examination as a compulsory item for physical examination of teachers and students.

2. Do not spit everywhere, cover your mouth and nose when coughing or sneezing, and wear a mask to reduce the spread of tuberculosis.

3. After suspicious symptoms of pulmonary tuberculosis appear or are diagnosed as pulmonary tuberculosis, you should take the initiative to report to the school, and don’t hide your illness or attend classes with illness.

4. Develop the habit of frequently opening windows for ventilation; Do a good job in campus environmental sanitation, and eliminate the dead corner of sanitation.

5. Ensure adequate sleep, reasonable diet, strengthen physical exercise and improve the ability to resist diseases.

Fourth, dengue fever

(A) disease science

Dengue fever is an acute mosquito-borne infectious disease caused by the spread of dengue virus through mosquito bites. Dengue fever has the characteristics of typical importation, suddenness, rapid spread, high incidence, general susceptibility of the population and high mortality of a few severe cases. The clinical features are sudden onset, high fever (sometimes up to 39℃), general muscle pain, joint pain, extreme fatigue, and some patients may have rash, bleeding tendency and lymph node enlargement. At present, the epidemic situation of dengue fever in Southeast Asia, South America, Africa and other places is more serious, and cases of dengue fever have appeared in Yunnan, Guangdong, Zhejiang, Hainan and other regions in China. At present, there are no vaccines and specific therapeutic drugs that can prevent the disease. The focus of treatment is to control pain with painkillers, usually acetaminophen (paracetamol).

(2) Prevention and control suggestions

Avoiding being bitten by mosquitoes is the key. Try to choose light-colored long-sleeved trousers and use mosquito repellent or other mosquito repellent drugs when going out.

2. Screen windows and screen doors should be installed in the residence. You can use mosquito-repellent incense, mosquito-repellent aerosol, etc. in the hotel room before going out. Even in high-end hotels, you should pay attention to indoor mosquito killing. Avoid staying in the dark and humid outdoors such as grass, shade and gazebo for a long time.

3. If symptoms appear, see a doctor in time. If you come back from dengue endemic areas (Yunnan, Guangdong, Zhejiang, Fujian and other domestic endemic areas, Southeast Asia, South America, Africa and other overseas endemic areas), please pay attention to your own health observation. If you have a persistent high fever within 2 weeks, accompanied by symptoms such as headache, orbital pain, muscle and joint pain, nausea, vomiting, rash, etc., you should go to a regular hospital as soon as possible, and inform the doctor of his recent residence history and remind him that he may have dengue fever; When staying at home or in hospital, do a good job in mosquito isolation (especially within 5 days after onset), including using mosquito nets, screen doors and screens, wearing long-sleeved underwear, spraying mosquito repellent and other measures to reduce unnecessary outdoor activities and prevent further spread.

V. Covid-19 infection

(A) disease science

At present, XBB series variants of Omicron subtype have become dominant in most provinces in China, and this trend is likely to continue in the future. The National Bureau of Disease Control and Prevention also said that the epidemic situation of COVID-19 in China is generally at a low level and in a wave-like fashion recently, and the epidemic situation has brought less pressure to local medical systems, so there will be no large-scale epidemic in the short term. However, it should be noted that cases of multiple infections with COVID-19 are more common. Through the search, we can find that the number of COVID-19-infected outpatients in hospitals has increased recently, and most patients are infected with Covid-19 or influenza virus.

(2) Prevention and control suggestions

1. Actively vaccinate. Elderly people aged 60 and above, people aged 18-59 with serious basic diseases, people with low immune function, people with high risk of infection, and people who have completed basic immunization or have been infected with Covid-19 should be actively vaccinated to further strengthen their autoimmune ability.

2. Pay attention to personal protection. Residents should wear masks in their daily trips, minimize unnecessary gatherings and keep social distance. Maintain good personal and environmental hygiene, wash hands frequently, often ventilate, pay attention to rest, pay attention to nutrition and enhance physical fitness.

3. Use drugs rationally and see a doctor as needed. After infection, residents should take corresponding treatment measures according to the severity of their own symptoms, implement self-care at home, reduce contact with their roommates, rationally use symptomatic drugs according to relevant guidelines, do a good job in health monitoring, and go to medical institutions in time if the condition worsens.

Six, monkeypox

(A) disease science

Monkeypox (Mpox) is a viral zoonotic infectious disease caused by Mpox virus. The main clinical manifestations are fever, rash and lymphadenopathy. Recently, many provinces and cities in China reported cases of monkeypox. Monkeypox cases are mainly men who have sex with men. Recently, there have been some cases of infection among women and medical staff.

(2) Prevention and control suggestions

1. Pay close attention to the epidemic information of monkeypox in the local area or travel destination in time to avoid direct contact with wild animals in high-incidence countries. Avoid catching, slaughtering and eating local animals raw.

2. Good hygiene habits, frequent cleaning and disinfection, and good hand hygiene.

3. If you find sex with a rash (especially in genitals, perianal parts, etc.), avoid close contact with it. Using condoms can’t completely prevent monkeypox virus infection.

4. The interpersonal transmission of monkeypox is mainly among men who have sex with men. It is suggested that men who have sex with men actively understand the knowledge of monkeypox prevention to avoid or reduce high-risk behaviors.

5. If you have symptoms such as fever, rash and lymphadenopathy of unknown reasons, you should take the initiative to seek medical treatment.

Seven, dog injury

(A) disease science

Rabies is a zoonotic acute infectious disease. Once it breaks out, the mortality rate is close to 100%. According to the data released by the World Health Organization (WHO), rabies still kills 59,000 people worldwide every year, and one person dies of rabies every 9 minutes, and 99% of the cases are caused by dog bites. Main symptoms (rabies): fear of water, fear of wind, pharyngeal muscle spasm and progressive paralysis. Raising awareness of rabies prevention, vaccinating dogs and strengthening post-exposure treatment of human rabies in epidemic areas are the most effective rabies prevention measures at present, and it is also the global consensus on rabies prevention.

(2) Prevention and control suggestions

1. Pet dog owners must consciously raise dogs in accordance with the law, vaccinate cats and dogs, and use leashes when going out to avoid dogs hurting people and spreading rabies virus.

2. Rabies can be prevented and cured. If you are scratched or bitten by a dog/cat, even if the wound is small, you should not be careless. You should seek medical advice in time. It is recommended to go to a medical institution with relevant qualifications for treatment, and do a good job in handling rabies after exposure according to the wound condition and personal immunization history.

3. After being scratched or bitten by a dog/cat, the individual should give first aid: if the wound is deep, especially the bleeding wound, you should first press the wound with a clean cloth to stop bleeding, and then rush to the hospital; If the wound surface is shallow or bleeding is not much, you can first clean the wound with flowing water or soapy water for 15 minutes, then use a clean paper towel to absorb the residual liquid at the wound, and then cover the wound with a clean cloth and seek medical attention as soon as possible. In addition to preventing rabies, we should also guard against other wound infections, such as tetanus infection.

4. Old people and children should receive more protection. Because the elderly and children have weak self-protection ability and lack of awareness of risk prevention, the incidence of animal injuries is high.

Original title: "It is related to health, beware of these infectious diseases! 》

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