Deeply understand and accelerate the development of new quality productive forces

　　Commentator of Qiushi magazine

　　"Developing new-quality productive forces is an inherent requirement and an important focus for promoting high-quality development. We must continue to do a good job in innovation and promote the accelerated development of new-quality productive forces."

　　On January 31, 2024, General Secretary of the Supreme Leader delivered an important speech when he presided over the 11th collective study in the Political Bureau of the Central Committee, systematically expounded the scientific connotation of new quality productivity from the combination of theory and practice, profoundly pointed out the great significance of developing new quality productivity, and put forward clear requirements for developing new quality productivity. From putting forward "new quality productive forces" during a local inspection in 2023, to emphasizing "developing new quality productive forces" at the Central Economic Work Conference, and then making a systematic exposition during the collective study of the Politburo, the General Secretary’s series of important expositions and major arrangements on developing new quality productive forces have profoundly answered the important theoretical and practical questions of "what is new quality productive forces, why should we develop new quality productive forces, and how to develop new quality productive forces", which provides a basis for promoting high-quality development in the new journey.

　　High-quality development needs the guidance of new productivity theory.

　　Marxism holds that productivity is the material premise of all social life, the most active and revolutionary factor to promote social progress, and the productivity standard is a fundamental standard to measure social development. Marx and Engels pointed out that "the sum of people’s productive forces determines the social situation". Unswervingly promoting the development of productive forces and constantly improving people’s living standards on this basis is the fundamental starting point of all our party’s work.

　　The fundamental task of socialism is to liberate and develop social productive forces, and the superiority of socialism over capitalism lies in its ability to develop productive forces faster and better. After the founding of New China, Comrade Mao Zedong proposed that "the purpose of socialist revolution is to liberate productive forces". After the reform and opening up, Comrade Deng Xiaoping clearly pointed out that "there are many tasks of socialism, but the fundamental one is to develop productive forces". Since the founding of the People’s Republic of China, our Party has only spent several decades leading the people to complete the industrialization process that developed countries have gone through for hundreds of years, promoting China’s development into the second largest economy in the world, and creating a miracle of rapid economic development that is rare in the world. It is extremely important to attach great importance to productivity standards, always adhere to the liberation and development of social productivity, and constantly enhance the comprehensive national strength of socialist countries.

　　Entering a new era, China’s economic development has entered a new stage. The CPC Central Committee with the Supreme Leader as the core regards adhering to high-quality development as the last word in the new era, consistently liberates and develops social productive forces, makes a series of major decisions and arrangements, and pushes China’s economy to a higher-quality, more efficient, fairer, more sustainable and safer development path. The level of productive forces has achieved great improvement and breakthrough development, forming a new qualitative state of productive forces development. In view of this new situation, the General Secretary of the Supreme Leader clearly pointed out that "the new quality productivity has been formed in practice and has shown a strong driving force and support for high-quality development".

　　At the same time, we should also see that there are still a lot of factors restricting high-quality development, such as some key core technologies being controlled by people, the problems of "big but not strong" and "all but not excellent" in the industry, and the pressure of transforming the production and living system to green and low carbon, and so on. To further promote high-quality development, we must form new industries, new models and new kinetic energy, firmly grasp key core technologies in our own hands, build a modern industrial system that is self-controllable, safe, reliable and competitive, build a green and low-carbon circular economy system, and realize connotative growth driven by innovation. In the final analysis, it is to achieve greater breakthroughs and greater development at the level of productivity. This puts forward a new topic for our theoretical development, and we need to further deepen our understanding of the new quality productivity. General Secretary of the Supreme Leader emphasized that the development of new quality productive forces "requires us to summarize and generalize theoretically to guide new development practice". General Secretary Supreme Leader’s important exposition on developing new-quality productive forces points out the important focus of promoting high-quality development, embodies a profound grasp of the development law of productive forces and the outstanding problems facing China’s development, and is a profound summary of the law of China’s economic construction, further innovating and developing Marxist productive forces theory, which is an important part of Supreme Leader’s economic thought and has important theoretical and practical significance. We must study deeply and deeply understand it and use it to guide practice.

　　Grasping the scientific connotation of new quality productivity

　　What is new quality productivity? General Secretary of the Supreme Leader pointed out: "In a nutshell, the new quality productivity is an advanced productivity that plays a leading role in innovation, gets rid of the traditional economic growth mode and productivity development path, has the characteristics of high technology, high efficiency and high quality, and conforms to the new development concept. It was born out of revolutionary breakthrough in technology, innovative allocation of production factors, and deep transformation and upgrading of industries. The basic connotation is the leap of laborers, labor materials, labor objects and their optimized combinations, and the core symbol is the substantial improvement of total factor productivity. Its characteristics are innovation, the key is high quality, and the essence is advanced productivity. " This important exposition profoundly points out the basic theoretical issues such as the characteristics, basic connotations, core symbols, characteristics, keys and essence of the new-quality productive forces, and provides a fundamental basis for us to accurately grasp the scientific connotation of the new-quality productive forces.

　　New-quality productivity is an advanced productivity with innovation as the leading role, and its characteristic is innovation. The key to grasping the new quality productivity lies in a deep understanding of the key role of innovation in improving productivity. Looking back at history, from the mechanization of the first industrial revolution in the 18th century to the electrification of the second industrial revolution in the 19th century, and then to the informationization of the third industrial revolution in the 20th century, subversive scientific and technological innovations have brought about great liberation of social productive forces and great leap in living standards, which fundamentally changed the development track of human history. Some countries have seized the rare opportunity of scientific and technological revolution and industrial transformation, and their comprehensive national strength has increased rapidly, even becoming a world power. At present, a new round of scientific and technological revolution and industrial transformation is ready to go, and some major disruptive technological innovations are creating new industries and new formats. Information technology, biotechnology, manufacturing technology, new material technology and new energy technology have penetrated into almost all fields, which has led to major group technological changes characterized by green, intelligence and ubiquity. We have ushered in the historic intersection of the new round of scientific and technological revolution and industrial transformation in the world and the transformation of development mode in China, and are faced with a once-in-a-lifetime historical opportunity. New quality productive forces have emerged as the times require and have continued to grow and develop in practice. New quality productivity represents the new direction and trend of scientific and technological revolution and industrial transformation, and represents the development direction of advanced productivity. To accelerate the formation of new quality productive forces is to gain a leading position in the development of productive forces, take the lead in new fields and new tracks, and win the initiative in development in fierce international competition.

　　Marx pointed out that "productivity, that is, the development of production capacity and its elements" and "labor productivity is developing with the continuous progress of science and technology". New quality productivity is the product of productivity development and scientific and technological progress, and it is a revolutionary promotion of human ability to transform nature. This promotion is holistic and fundamental, and as its constituent elements, workers, labor materials and labor objects must also have new connotations. As far as workers are concerned, workers are the most active factor in productivity. What matches the new quality productivity is no longer ordinary workers who focus on simple repetitive work, but strategic talents who can create new quality productivity and applied talents who can master new quality production materials skillfully. As far as labor materials are concerned, as a "measuring instrument for the development of human labor force", with the development and wide application of original technology and subversive technology, more and more new production tools will be produced, and old and backward production tools will be gradually replaced by new and advanced production tools, which is also the main symbol of the development of productive forces. As far as the object of labor is concerned, the improvement and extensive use of labor materials will inevitably lead to the expansion of the scope of labor objects, including not only traditional natural materials, but also intangible forms such as data that are not limited by space and time.

　　Only by combining various factors of production can we form realistic productive forces. New quality productivity is not only reflected in the innovative development of various factors, but also in the innovative development of the combination of production factors. With the development and changes of laborers, labor materials and labor objects in the new quality productivity, the optimized combination of the three will also undergo revolutionary changes, bringing new industries, new formats and new models, and forming new kinetic energy and new advantages that drive economic development. Productivity determines production relations, and production relations react on productivity. The formation of new quality productive forces will inevitably lead to revolutionary changes in production relations, and it is necessary to form new production relations to adapt to them, and protect, liberate and develop them. Constantly reforming and perfecting the relations of production and forming new management modes and new institutional mechanisms are important guarantees for promoting the continuous development of new quality productive forces.

　　In a word, we should deeply realize that the new quality productivity is not the local optimization and simple iteration of the traditional productivity, but the advanced productivity, which is spawned by the revolutionary breakthrough of technology, the innovative allocation of production factors and the deep transformation and upgrading of industries. It will certainly bring about changes in the development mode and production mode, promote the new leap of China’s social productivity and lay a more solid material and technological foundation for building a socialist modern country in an all-round way.

　　Promote new quality productivity and accelerate development.

　　"We can’t fall behind on the new track", "We should catch up, strive to achieve, run and even lead". At the Central Economic Work Conference in 2023, the words of the Supreme Leader General Secretary were inspiring. On the new journey of building a strong country and national rejuvenation, the most fundamental thing to promote Chinese modernization is to realize the modernization of productive forces. The essence of new quality productivity is advanced productivity. It is necessary to unify thoughts and actions with the spirit of the important speech of the Supreme Leader General Secretary and the decision-making arrangements of the CPC Central Committee, focus on the central task of economic construction and the primary task of high-quality development, further enhance the consciousness and initiative of promoting the development of new-quality productive forces, and improve the practical skills of promoting the development of new-quality productive forces.

　　— — Accelerate scientific and technological innovation. Scientific and technological innovation can give birth to new industries, new models and new kinetic energy, which is the core element of developing new quality productivity. We must strengthen scientific and technological innovation, especially original and subversive scientific and technological innovation, accelerate the realization of high-level scientific and technological self-reliance, lay a solid battle for key core technologies, and cultivate new kinetic energy for developing new quality productive forces.

　　— — Accelerate industrial innovation. Industry is the carrier of productive forces, and scientific and technological achievements can only become social productive forces through industrialization. It is necessary to apply scientific and technological innovations to specific industries and industrial chains in a timely manner, transform and upgrade traditional industries, cultivate and expand emerging industries, lay out and build future industries, and improve the modern industrial system. Layout the industrial chain around the development of new quality productivity, improve the resilience and safety level of the industrial chain supply chain, and ensure that the industrial system is self-controllable, safe and reliable.

　　— — Accelerate the innovation of development mode. Green development is the background of high-quality development, and new quality productivity itself is green productivity. We must speed up the green transformation of development mode, firmly establish and practice Lucid waters and lush mountains are invaluable assets’s concept, unswervingly take the road of ecological priority and green development, and vigorously advocate a green and healthy lifestyle in the whole society.

　　— — Accelerate the innovation of system and mechanism. The relations of production must meet the requirements of the development of productive forces. To develop new quality productive forces, we must further deepen the reform in an all-round way and form a new type of production relationship that is suitable for it. It is necessary to deepen the reform of the economic system and the scientific and technological system, and strive to get through the blocking points that constrain the development of new quality productive forces. Expand high-level opening to the outside world and create a good international environment for the development of new quality productive forces.

　　— — Accelerate the innovation of talent work mechanism. Talent is the first resource, and the essence of innovation drive is talent drive. In the final analysis, the development of new quality productive forces depends on innovative talents. In accordance with the requirements of developing new quality productive forces, we should smooth the virtuous circle of education, science and technology and talents, and improve the working mechanism of talent training, introduction, use and rational flow. Improve the income distribution mechanism in which factors participate, and create a good atmosphere to encourage innovation and tolerate failure.

Since Kunqu Opera was selected into UNESCO’s "Representative Works of Oral and Intangible Heritage of Humanity" in 2001, the government-led protection of intangible heritage in China has gone through 17 years. Although China’s intangible cultural heritage protection has not been carried out for a long time from an international perspective, with the great attention of the CPC Central Committee and the State Council, and the joint efforts of cultural administrative departments at all levels and all walks of life, China’s intangible cultural heritage protection has made rapid progress and achieved fruitful results, which not only created a vivid situation for the inheritance and development of intangible cultural heritage in the contemporary era, but also provided many methods and measures for the international community with China experience.

Establish rules and regulations, and build an intangible cultural heritage protection system.

In order to comprehensively understand and master the species, quantity, distribution, survival and inheritance of intangible resources in various regions and ethnic groups, from 2005 to 2009, China launched the first nationwide survey of intangible resources, and the total number of intangible resources was nearly 870,000. On this basis, China has established a national, provincial, municipal and county-level intangible cultural heritage list system. Up to now, the State Council has approved and published 4 batches of 1,372 national representative projects, and 15,550 provincial and municipal representative projects have been approved and published by various provinces, autonomous regions and municipalities. The former Ministry of Culture identified 4 batches of 1,986 national representative inheritors, and 14,928 provincial and municipal representative inheritors were identified by all provinces, autonomous regions and municipalities. China has been selected into UNESCO’s list of intangible cultural heritage projects, reaching 39, ranking first in the world.

In 2011, China promulgated and implemented the Intangible Cultural Heritage Law of People’s Republic of China (PRC). The promulgation of this law is a milestone, which provides a solid legal guarantee for the protection of intangible cultural heritage in China. The former Ministry of Culture has successively issued regulations on the protection and management of non-legacy representative projects, the identification and management of representative inheritors, the management of special funds, and the construction and management of cultural and ecological protection zones. By the end of 2017, 26 provinces, autonomous regions and municipalities across the country had promulgated regulations on the protection of intangible assets.

With the deepening of understanding, China proposes to protect the intangible cultural heritage and the environment where it breeds and develops. Since the establishment of Minnan Cultural and Ecological Protection Experimental Zone in 2007, China has successively set up 21 national cultural and ecological protection experimental zones in areas with concentrated non-legacy projects, distinctive features and complete contents and forms, and strived to promote each experimental zone to become a cultural and ecological zone with rich heritage, strong atmosphere, distinctive features and benefits for the people.

Carry forward and improve the practical ability of inheritance.

On the basis of continuous improvement of the intangible cultural heritage protection system, in recent years, the former Ministry of Culture put forward three important concepts: "protection in improvement", "intangible cultural heritage entering modern life" and "seeing people, seeing things and seeing life". A series of work focusing on the protection of inheritance practice, inheritance ability and inheritance environment has been carried out, which has brought intangible cultural heritage back to life and revived its vitality in contemporary production and life.

The work of intangible cultural heritage records is a basic work of intangible cultural heritage protection. Since the 18th National Congress of the Communist Party of China, the former Ministry of Culture has carried out non-legacy rescue records on the basis of previous investigation records, and gradually summed up experience and expanded and established the non-legacy record project. By the end of 2017, the central government had supported the rescue recording of 839 national representative inheritors, and the unique skills and cultural memories carried by a group of representative inheritors were recorded and preserved.

Traditional arts, traditional skills and traditional medicine and drug processing are intangible items, which are originally produced in production practice, and their cultural connotation and technical value are reflected by the production process, and the general public share their charm by owning and consuming materialized products or works of traditional skills. In view of this type of intangible cultural heritage projects, China puts forward the concept of "productive protection" to encourage and support the inheritors to actively resume production and truly realize live transmission.

In order to further promote the inheritance and revitalization of traditional crafts and expand the contingent of non-genetic inheritors, in 2015, the former Ministry of Culture and the Ministry of Education launched the training program for non-genetic inheritors in China. By the end of 2017, a total of 48,000 people had established self-confidence, been inspired and enhanced their abilities through research and training; The excellent works and rich products created and produced by the students fully show the great energy that can be generated after the creativity and imagination of the vast number of people are released.

In order to explore effective measures to revitalize traditional crafts, since March 2016, the former Ministry of Culture has supported relevant enterprises, universities and institutions to set up 10 traditional craft workstations in traditional craft gathering places, involving embroidery, wood carving, lacquer art, metal forging, traditional residential building skills and other categories. Up to now, Hami Station in Xinjiang, Xiangxi Station in Hunan, Leishan Station in Guizhou, Guoluo Station in Qinghai and Huangshan Station in Anhui have developed more than 1,000 kinds of practical products that have entered modern life, effectively promoting the creative transformation and innovative development of traditional crafts.

Accurate poverty alleviation, from "fingertip skill" to "fingertip economy"

Through productive protection, on the one hand, traditional crafts are carried forward, on the other hand, the income of the masses is increased and the poor people are helped out of poverty. Some inheritors said that "fingertip skill" has really been transformed into "fingertip economy".

In 2017, the former Ministry of Culture focused on supporting non-hereditary people in ethnic areas, remote areas and poverty-stricken areas to participate in the research and training program. Through training, the trainees not only improved their ability to inherit and practice, but also played a leading role in radiation. Take Qiandongnan Miao and Dong Autonomous Prefecture of Guizhou Province as an example. According to incomplete statistics, in the first half of 2017, only 225 students in this state participated in the research and training program, with the mode of "inheritor+cooperative/company+farmer", achieving an annual sales income of more than 750 million yuan. Excellent students returned to the local area to train new students and drive about 9,500 people to obtain employment, of which the poor accounted for 58% of the total employment, and each enterprise drove 47% on average.

Traditional process workstations have also played an important role in promoting precision poverty alleviation. In Hami, Xinjiang, 231 cooperatives and embroidery associations have been established, and more than 17,000 orders have been received. Nearly 1,000 embroidered mothers directly participated in the production of orders, with an average monthly income of 1,500 yuan per person. Hunan Xiangxi Workstation launched the "Let Mom Go Home" program to attract migrant women to return to their families by increasing the income of embroidered mothers. The workstation also negotiated 2,800 sets (pieces) of Miao embroidery orders with companies in Jinan, Shenzhen and other places, amounting to 500,000 yuan, which led to more than 160 rural women’s employment at home.

Spread communication and let excellent traditional culture shine on the world stage.

This year’s government work report proposes to carry forward Chinese excellent traditional culture and deepen cultural exchanges between China and foreign countries. As an important part of Chinese excellent traditional culture and a "living" heritage, intangible cultural heritage plays an important role in strengthening national cohesion and centripetal force and promoting exchanges and mutual learning between Chinese and foreign civilizations.

According to statistics, in the past five years, 320,000 exhibitions of intangible cultural heritage have been held nationwide, with 540 million people participating. A variety of intangible cultural heritage publicity and exhibition activities have comprehensively demonstrated the outstanding practical achievements of intangible cultural heritage protection in recent years, creating an atmosphere for the whole society to inherit and develop excellent traditional culture. The former Ministry of Culture made great efforts to promote the protection, inheritance and revitalization of intangible cultural heritage projects, and supported various localities to carry out a series of performance activities through activity guidance, repertoire mobilization, financial subsidies, dissemination and promotion, which improved the exhibition degree of intangible cultural heritage projects, increased the frequency of practice, and maintained and expanded the survival and development space of intangible cultural heritage projects.

In recent years, international exchanges and cooperation in the field of intangible cultural heritage have been deepening. China actively participates in the meetings of the Intergovernmental Committee for the Protection of Intangible Heritage and the formulation of relevant international rules, and draws on the theoretical methods and successful practices of other countries to provide China’s plan and China’s experience for the protection of intangible heritage in the world. UNESCO has established the Asia-Pacific World Heritage Training and Research Center and the International Training Center for Intangible Cultural Heritage in China. Through international training and exchange activities, these institutions have made important contributions to promoting the capacity building of relevant countries in the Asia-Pacific region for the protection of intangible cultural heritage.

China and Mongolia jointly declared Mongolian long-tune folk songs as masterpieces of human intangible cultural heritage, and cooperated in field investigation and protection of Mongolian long-tune folk songs; Carry out relevant exchange activities with Thailand, Japan and Britain on traditional crafts and intangible cultural heritage protection, laying a solid foundation for strengthening cooperation with foreign institutions in the field of intangible cultural heritage. In China, 35 overseas China cultural centers and 512 Confucius Institutes have been built, and intangible trainings such as Tai Chi and calligraphy have been well received, and traditional festivals and folk activities in China have been widely spread. (Reporter Wang Xuesi)

The renovation of old residential areas is a major livelihood project and development project. General Secretary of the Supreme Leader pointed out that the renovation of old residential areas is an important task to enhance people’s sense of gain, and it is also an important part of the implementation of urban renewal. The Community Construction Department of the Urban Construction Department of the Ministry of Housing and Urban-Rural Development (hereinafter referred to as the "Community Department") takes the transformation of old residential areas as the focus of doing practical things for the masses, and solves the "great livelihood" with "small incision" to continuously enhance the people’s sense of acquisition, happiness and security.

This year, this young team won the National Worker Pioneer. "The renovation of old residential areas is an important task to improve people’s quality of life, and it is a practical matter of people’s livelihood around the people. We are honored to be able to shoulder the heavy responsibility and win the honor, and we feel even more responsible. " Relevant comrades in the community office said.

Find out the base, pilot first, and clarify the direction of the transformation path

Most of the old residential areas were built before 2000. The construction standards of these residential areas are low, coupled with long-term neglect, incomplete municipal supporting facilities, aging houses and other outstanding problems. There are shortcomings in facilities, environmental supporting facilities and public services, which is far from the growing needs of the people for a better life. Residents have a strong willingness to transform. Old residential areas are large in quantity and wide in scope, and the task of renovation is heavy. How to promote renovation in a solid and orderly manner throughout the country?

Understanding what the masses think and expect, and learning from the grassroots is the first priority. The Community Department organized 20 departments and units to conduct in-depth research on 213 old communities in 93 cities and counties, and combed and analyzed the current situation, transformation needs and experience of old communities. Subsequently, Shandong and Zhejiang provinces and eight cities including Shanghai and Suzhou were organized to deepen the pilot projects, and special classes for joint work were set up with local comrades to jointly explore the establishment of nine mechanisms, such as mobilizing the masses to jointly build, sharing reconstruction funds and integrating and utilizing existing resources, and to "explore the road" in the reconstruction projects in detail, so as to accumulate experience for comprehensively promoting the transformation.

On the basis of comprehensive investigation and summing up the pilot experience, the Community Department took the lead in drafting the Guiding Opinions on Comprehensively Promoting the Renovation of Old Urban Residential Areas, which defined the target tasks and the scope of objects, established a package of support policies to meet the needs of renovation projects in terms of approval of renovation projects, taxation and finance, land and so on, basically formed the institutional framework for the renovation of old urban residential areas, and the renovation work was rapidly and comprehensively promoted throughout the country.

Guide the whole process and do a good job in deployment and implementation.

Since 2019, the country has started to renovate nearly 220,000 old urban communities, benefiting hundreds of millions of people. However, the larger new start-up tasks every year, coupled with the projects under construction, have brought great pressure to the streets and communities at the grassroots level. How to make the policy better adapt to the needs of the grassroots and land solidly?

The community department insists on keeping its eyes down, stepping down, throwing itself down and sinking into the front line, so that the policy can be passed on layer by layer from formulation to promotion to landing.

"The transformation of old residential areas is the initial intention and mission of this office. We are both policy makers and policy practitioners and implementers." Relevant comrades said.

According to reports, since 2019, the renovation of old residential areas has been included in the affordable housing project, and the General Office of the State Council has issued guidance. The Ministry of Housing and Urban-Rural Development, together with relevant departments, put forward targeted work requirements for the renovation work in that year according to the latest situation, tasks and objectives, and new situations and problems arising in the renovation, and made clear the "positive list" and "negative list" of work, so as to promote all localities to do their best and do their best to promote the renovation well and quickly.

With the gradual advancement of the renovation of old residential areas, the Community Department promptly answered questions about the difficulties encountered in various localities, followed up and summarized the deepening innovations in the implementation of policies in various localities, organized and printed seven batches of List of Replicable Policy Mechanisms for the Renovation of Old Urban Residential Areas, promoted the replicable experiences and practices in pioneering areas, guided all localities to learn from them, accelerated the improvement of working mechanisms and policy systems that meet the needs of renovation, and promoted the implementation of renovation policies.

For example, in order to solve the problem of "public needs and women need to face" in the transformation of old residential areas, the community department guides all localities to fully mobilize the masses to participate, ask for the needs of the people, ask for the people, ask for the benefits of the people, and seek the greatest common denominator of the transformation effect.

In the residents’ meeting hall of an old residential area in Qingdao, Shandong Province, a young cadre from the community office discussed the renovation plan of the residential area with the residents. Because there are many people in the surrounding primary schools during school hours, the residents are very concerned about the design plan of optimizing the internal traffic routes and getting through the fire exits. "Making policies and implementing them are different. Every old residential area has its own characteristics, and the needs of each resident are different. The renovation plan must be determined according to the wishes of residents and the actual situation of the residential area. In this process, it is very important to be with residents, want to be together, and be together. " The young cadre said with emotion.

Experience comes from grassroots practice and wisdom. The community department adheres to the typical demonstration and leads the way, and promotes the transformation process in various places with demonstration projects. Since 2021, the Community Department has identified a number of contact points communities every year, and adopted the methods of leaders’ efforts, young cadres’ on-the-spot investigation, and experts’ assistance to help the communities break the blocking points of renovation, create demonstration model projects, and share experiences and experiences with community cadres in the streets where various renovation communities are located throughout the country.

In order to evaluate the transformation work more scientifically and objectively, the community office has defined the measurement standard of the transformation work through performance evaluation, supervision and encouragement, so as to make the policy baton and the evaluation index system more unified. During the research and establishment of the National Statistical Investigation System for the Renovation of Old Urban Residential Areas, the Community Department, together with grassroots comrades, repeatedly studied the connotation of each statistical indicator in order to be accurate and efficient, focusing on the goal of timely and accurately reflecting the progress of the renovation and minimizing the statistical burden. "This set of statistical indicators has clear logic and strong pertinence, which is very helpful for guiding and promoting local work. The progress of the work can be clearly reflected in the statistics. Behind the figures are the transformation results that every resident can see and touch, and they are all tangible results. " A grassroots cadre responsible for the renovation of old communities said.

The central and local governments have resonated at the same frequency and exerted their strength in the same direction, overcoming difficulties and taking advantage of the situation. The policy implementation has not only not weakened, but the signal has become stronger and stronger.

Cooperate to fill the shortcomings and improve the supporting facilities

Living and working in peace and contentment is the simplest wish of China people. Residents spend most of their daily life, food, clothing, housing and transportation in the community. In order to do the "last mile" of serving the masses well, the Community Department cooperated with various departments Qi Xin to integrate resources and fill the shortcomings of facilities and services.

"what is missing, what to make up." The Community Office guides all localities to explore the working method of "physical examination before renovation", and before renovation, it conducts a thorough investigation of the facilities in the community, focuses on residents’ needs, adheres to goal orientation and problem orientation, adopts "menu-based" renovation, and makes precise efforts with "one district, one policy", giving priority to solving the urgent problems of the masses, using limited funds at the cutting edge and changing them into residents’ "hearts".

"Stick to the bottom line of safety" and focus on eliminating potential safety hazards. Accelerate the renovation of aging and hidden dangers of gas, water supply, heating, drainage, power supply, communications and other pipelines and pipelines, and put the concept of safe development throughout all links and the whole process of renovation.

"One old and one young" is the main concern of most families. The Community Department guides all localities to actively revitalize the housing and land resources in the community and surrounding areas, and add service facilities such as home care service centers, canteens for the elderly and children’s post stations according to local conditions. In conjunction with the State Sports General Administration, the "national ball into the community" campaign was launched, and small sports and fitness facilities such as table tennis tables were added for old communities to allow residents to move at their doorsteps.

In recent years, residents have a high voice for installing elevators in existing houses, and the community department has faced up to the difficulties of reaching a consensus and raising funds, and adhered to the combination of rule of law and rule of virtue to help solve the problem of "it is difficult for suspended elderly people to go downstairs". Seize the favorable opportunity when the National People’s Congress promulgated the law on barrier-free environment construction, and promote national legislation to support the installation of elevators in existing multi-storey houses in old urban communities. Give play to the role of grassroots organizations in street communities, take party building as the guide and residents’ consultation as the basic working methods, and promote residents to reach a consensus. In conjunction with the Supreme People’s Court, a typical case was issued to guide residents to correctly understand the legal provisions applicable to installing elevators, and to carry forward the traditional virtues of the Chinese nation, such as being good neighbors and helping each other.

Great cause inspires people to forge ahead. The achievements made by the Community Office courageously come from the broad masses of the people’s support for the major decision-making arrangements of the CPC Central Committee and the State Council, and also reflect the hope of millions of grassroots community workers and community residents to work together to build a beautiful home.

　　[XCAR Five Questions and Five Answers Original]

　　On August 22, 2016, the new E-class long-axis version of Beijing Benz was officially launched, and a total of six models were launched, with a price range of 436,800-499,800 yuan. The Mercedes-Benz E-Class long-axis version listed this time is the tenth generation model and the third generation model made in China. The new Mercedes-Benz E-class long-axis version continues the essence of S-class in appearance and interior. Compared with the standard-axis version, the wheelbase has increased by 140mm, and the configuration has been improved in all directions. The competitiveness is no longer the same as that of the old model. What are the highlights of the new Mercedes-Benz E-Class Long Axis Edition? Can face value and configuration conquer consumers? Is the comprehensive competitiveness strong? The following is to answer these questions through the special column "Five Questions and Five Answers" of Aika Automobile. Let’s talk about the editor’s personal thoughts in advance. When I see the brand-new Mercedes-Benz E-Class long-axis version, I want to buy one especially even if I borrow money. I wonder if you will have this idea after reading the following introduction!

　　Question 1: Which generation is the new Mercedes-Benz E-Class long-axis version?

　　In fact, friends who are interested in Mercedes-Benz E-Class must have a better understanding of its history, but I believe there are still many netizens who are not very clear about it, or only know about several generations of models that are closer to us. In fact, the development of Mercedes-Benz E-Class has experienced ten generations of models. For a model with a history of nearly 70 years, we have no reason not to understand its past. In other words, the first generation of Mercedes-Benz E-Class has been very far away from me. At that time, my parents were not born yet, so I couldn’t learn about the past of Mercedes-Benz E-Class from my parents, so I could only collect materials from all directions. If there is any poor introduction, please forgive me.

　　The first generation models are for you who like nostalgia.

　　Need to remind everyone that before the launch of the mid-term redesign of the sixth-generation Mercedes-Benz E-Class, it was not named after the familiar "E-Class", but named after the chassis number of W plus number.

　　　 Let’s first look at what the first generation of Mercedes-Benz E-Class looks like. The birth of the first generation of Mercedes-Benz E-Class dates back to 1947. After World War II, Mercedes-Benz resumed production of 170V and 170S models with chassis codes W136 and W191. The first generation of Mercedes-Benz E-Class was improved according to the model before World War II. The features such as independent headlights and independent rims are very obvious and full of retro style.

　　The second generation Mercedes-Benz E, the first sedan captain, is like this.

　　In 1953, the second generation Mercedes-Benz E-Class was born. The model was named 180 and the chassis number was W120. The second-generation Mercedes-Benz E-Class has completely escaped from the shadow of the first-generation model, and it is also the first sedan of Mercedes-Benz E. It adopts a non-loaded body to ensure spacious interior space. In terms of power, it adopts a 1.8L four-cylinder engine with a maximum power of 52Ps, and the transmission is matched with a 4-speed manual transmission. In 1955, the second generation Mercedes-Benz E introduced an upgraded model 190 with chassis code W121, which was not discontinued until 1961.

　　The sales volume of the fin-shaped tail of the third-generation model exceeded 620,000.

　　In 1961, Mercedes-Benz introduced the third generation E-Class with chassis code W110, including two models: 190c/190Dc. The biggest change of this generation is the fin-shaped rear design. The body size has also been upgraded, with a length of 4730mm and a wheelbase of 2700mm.

　　　 In terms of power, the 190c is still equipped with a 1.9L gasoline engine with a maximum power of 80Ps, while the 190Dc is equipped with a brand-new 2.0L diesel engine with a maximum power of 55Ps. Since 1962, W110 series has added a four-speed semi-automatic gearbox on the basis of a four-speed manual gearbox. In addition, in the later period of W110 series, a 230 model equipped with a six-cylinder 2.3L gasoline engine was added for the first time, with a maximum power of 105Ps. By the end of production in 1968, the third-generation Mercedes-Benz E-Class sold a total of 620,000 vehicles.

　　The fourth-generation models have sold more than one million years ago.

　　In January 1968, Mercedes-Benz officially launched the brand-new Stroke Eight "/8" car series, which is the fourth generation Mercedes-Benz E, with the chassis code W114/W115. This generation of cars has changed greatly in appearance, giving up the fin-shaped rear design of the third generation models and using a lot of concise and lively design styles. In addition, this generation of Mercedes-Benz E-Class models began to enrich, providing a total of 15 models for consumers to choose from, which is also a huge vehicle layout today.

　　In addition, it should be noted that the parking brake of the fourth-generation Mercedes-Benz E bid farewell to manual operation, but adopted the pedal-operated auxiliary brake that we are very familiar with, and at the same time adopted the diagonal swing shaft on the rear suspension, which improved the overall balance, comfort and stability of the vehicle. In terms of power, the W114 series is equipped with a six-cylinder engine, and the upgraded W115 is equipped with a five-cylinder or four-cylinder engine. The top 250CE model also joined the Bosch D-Jetronic electronic fuel injection system for the first time. The fourth-generation Mercedes-Benz E-Class didn’t stop production until 1976, and the cumulative sales volume was close to 2 million.

　　The fifth-generation car was made in China for a short time but left an eternal memory.

　　In 1976, Mercedes-Benz officially launched the fifth-generation Mercedes-Benz E-Class with chassis code W123. This generation of cars has undergone minor changes in appearance, such as changing the lights to horizontal design, and the shape of the water tank grille at the lower part of the front face is also very modern. This generation of Mercedes-Benz E launched the five-door travel version, two-door Coupe version and four-door long-axis version for the first time.

　　In terms of safety, the fifth-generation car has also made a qualitative leap. First, the fuel tank is placed on the rear axle of the car to reduce the danger caused by collision. In addition, a new safety steering column is added, which can fall off sideways in a side collision to prevent the steering wheel from folding into the car in an accident and causing harm to the people inside the car. In the mid-term change, this generation of E-class supports the optional ABS and driver airbag, and the safety is further improved. In terms of power, this generation of Mercedes-Benz E-Class adopts a new 2.8L inline 6-cylinder DOHC fuel injection engine on the 280E model, with a maximum power of 142Ps.

　　It should be noted that in 1988, the fifth-generation E-Class was also introduced from Changchun FAW in the form of CKD, with a total volume of 828. Less than 1,000 of these vehicles are mainly used by senior national leading cadres and foreign guests, and the number of them entering private homes is very small, which cannot be compared with today’s domestic E-class.

　　The sixth-generation car was officially named "E-Class Car" and was first imported into China.

　　In 1985, Mercedes-Benz introduced the sixth generation of Mercedes-Benz E-Class, and the chassis code was W124. In June 1993, the name of "E-Class sedan" in E+ digital mode was formally determined. This generation of E-Class sedan was also the first E-Class imported from China by Mercedes-Benz.

　　The sixth-generation E-class has changed greatly in appearance, and the overall design is more elegant and stable, and the convertible version has been launched for the first time. The weight of this generation of cars has been optimized, the handling performance is better, and the aerodynamic design is equally excellent. The drag coefficient of 0.28 is the best evidence. In terms of safety, the driver’s airbag and ABS have been changed from the option of the previous generation to the standard, and new options such as the co-pilot airbag and ASR traction control system have been added.

　　In terms of power and chassis, in addition to retaining the four-cylinder, five-cylinder and six-cylinder engines, this generation of models has also introduced a 500 E model equipped with a 5.0L V8 engine, with an acceleration time of 6.1 seconds from 0 to 100 km/h and a maximum speed of 250km/h, making it the first model equipped with the first generation of 4MATIC four-wheel drive system. In terms of chassis, this generation of models adopts front multi-link and rear independent suspension, which is more excellent in comfort and handling. In addition, in 1986, the two-door Coupe was also equipped with a 5.6L V8 engine with a completely independent cylinder head developed by AMG, which was only an engine manufacturer at that time. The maximum power reached 360Ps and the 0-100km/h acceleration time was 5.4 seconds. Then in 1990, Mercedes-Benz officially cooperated with AMG, and the launch of E 60 AMG and E 36 AMG created the history of E-class AMG models.

April 27th

Xiaomi ecological chain enterprise

Ningbo qingmei electrics technology co., ltd

"Intelligent Manufacturing Project of Millet Dishwasher"

Sign a contract to settle in Zhangjiagang High-tech Zone

The total investment of the project is 500 million yuan.

This cooperation will give full play to the advantages of both sides in the field of intelligent manufacturing and innovation ecology, inject strong kinetic energy into regional industrial upgrading, and create a new benchmark for the smart home appliance industry in the Yangtze River Delta.

Xiaomi Dishwasher Intelligent Manufacturing Project signed a contract to settle in Zhangjiagang.

Intelligent manufacturing project of Xiaomi dishwasher

The land area is about 35 mu.

The total construction area is about 60,000 square meters

Relying on the core technical advantages of Qingmei Electric in the field of smart dishwashers, the project combines the innovative resources of Xiaomi ecological chain and the industry accumulation of gold medal home, focuses on the integrated research and development of cabinets and electricity and the expansion of smart kitchen scenes, and is committed to building a digital factory integrating design, production and sales.

Effect drawing of intelligent manufacturing project of millet dishwasher.

According to reports, the project will mainly build

3 intelligent dishwasher production lines, injection molding workshop,

Sheet metal workshop, intelligent warehouse,

Digital national laboratory, etc.

The main products are desktop series, full-size embedded dishwasher series, full-size embedded dishwasher series and so on. It is planned to produce 500,000 intelligent dishwashers annually. After the project is put into production, it is estimated that the annual output value will be 800-100 million yuan.

Xiaomi intelligent dishwasher product map.

As the sole partner of Mijia Dishwasher’s new platform, Qingmei Electric Appliance is a national high-tech enterprise and the drafting unit of the national standard of "Performance Test Method for Household Electric Dishwashers", with nearly 200 technical patents for dishwashers in four years.

In 2023, Qingmei Electric signed a three-year strategic cooperation agreement with Xiaomi Communication Technology Co., Ltd., and reached a strategic cooperation R&D agreement with Jinpai Kitchen Cabinet Home Technology Co., Ltd. in the same year to jointly lay out digital smart kitchens and build an integrated product platform for cabinets and electricity. At present, the products of Qingmei Electric include a full range of dishwashers, a kitchen center with integrated cabinet and electricity, and other emerging kitchen appliances. Leading the industry in the core technologies of dishwashers, such as integration of consumption and storage, intelligent delivery of dishwashing liquid, washing and drying.

Except for the millet dishwasher

Recently, many intelligent manufacturing projects have settled in Suzhou.

In order to speed up the construction of modern production system

Cultivate and develop new quality productivity and help bring in new kinetic energy

On April 27th, Wuzhong Taihu New Town Investment Promotion Project was signed. Eight innovative projects with a total investment of 3.2 billion yuan were signed and settled in Wuzhong, covering emerging fields such as intelligent travel and home service robots.

The eight projects are the intelligent high-end scooter, the unbounded high-end electric motorcycle, the high-end new energy tram of Jiexing Technology, the high-end new energy tram of Yuechuan Tuojing, the lawn mowing robot, the surge future swimming pool robot, the atomic remodeling 3D printing equipment and the R&D center of the clean-bound cruise window cleaning robot. Two of them are headquarters projects and six are R&D and production center projects. After the project is put into production, it is estimated that the output value will exceed 15 billion and the number of R&D personnel will reach 20,000.

Recently, a new project of Yangcheng Digital Valley Project in Jinjihu Business District of Suzhou Industrial Park was signed and settled. Among them, Suzhou Chineydy Intelligent Manufacturing Co., Ltd. signed a contract to build a new Yuanshu workshop. Chineydy Intelligent, a leading enterprise of artificial intelligence, integrates R&D, design and manufacturing, takes excellent engineering design R&D and software algorithm R&D as the strategic direction, and is committed to providing process solutions for global partners. Up to now, Chineydy Intelligent has won about 40 patents for inventions and utility models. The contracted area exceeds 15,000 square meters, which indicates that the enterprise will start a new journey in the field of intelligent equipment R&D and manufacturing.

As an important carrier of strategic emerging industries in Yangcheng Digital Valley Area, the newly-built Yuanshu Workshop focuses on frontier fields such as 5G+ industrial Internet, integrated circuits, medical devices and new materials, and takes the deep integration of "intelligence+industry" as the core to create an industrial demonstration zone of "changing intelligence from digital to network". The entry of Chineydy Intelligent will further strengthen the key link of the newly-built Yuanshu Workshop in the intelligent equipment industry chain.

On April 18th, brukner, the world’s leading machine and system manufacturer, signed a cooperation agreement with Suzhou Industrial Park Management Committee, and will invest 100 million US dollars to build its Asia-Pacific headquarters base integrating high-end manufacturing, R&D innovation, sales settlement and supply chain procurement in the park.

Brukner Group is a global leader in film stretching technology and one of the largest manufacturers of packaging machinery and equipment systems, providing large-scale high-end packaging production equipment and solutions for food, medical, automobile and daily consumer goods industries for a long time. This signing, brukner Group invested 100 million US dollars to introduce high-end film biaxial stretching equipment and solutions in the park, and build a comprehensive headquarters base integrating high-end manufacturing, R&D innovation, sales settlement and supply chain procurement. In the future, this headquarters base will become an important strategic hub for brukner Group to expand the Asia-Pacific market.

Original title: "Another project of Xiaomi settled in Suzhou! 》

Read the original text

In 1970, the Long March-1 carrier rocket successfully launched China’s first artificial earth satellite "Dongfanghong-1". Information photo

　　On the occasion of the May 1 ST International Labor Day in 2019, the Central Propaganda Department and the All-China Federation of Trade Unions publicly released the advanced deeds of "the most beautiful workers" in 2019 to the whole society. The picture shows the overall design team of the deep space exploration spacecraft system of the General Department of China Academy of Space Technology of China Aerospace Science and Technology Corporation at the release ceremony on April 21st. Xinhua news agency

　　The report of the 19th National Congress of the Communist Party of China expounded the initial intention and mission of the Communist Party of China (CPC) people to "seek happiness for the people of China and rejuvenation for the Chinese nation". For the happiness of China people and the rejuvenation of the Chinese nation, the purpose of China Academy of Space Technology (hereinafter referred to as "Academy") is to develop China’s space industry, serve the national strategic needs, build a world-class aerospace enterprise, and support the construction of a space power. While the whole Party is carrying out in-depth education on the theme of "Do not forget your initiative mind, Keep in mind the mission", it is of great significance to grasp, follow and apply the development law of China’s space industry, stick to its original intention and shoulder the mission bravely, so as to accelerate the development of China’s space industry and better shoulder the historical responsibility of building a space power.

　　1. Grasp the development law of China’s space industry and adhere to the development path of space industry with China characteristics.

　　Looking back on the development of China’s space industry, the development law of China’s space industry is a magic weapon for China’s space industry to create new glories from scratch and from small to large, and it is also an important cornerstone for carrying forward the past and forging ahead courageously, which must be adhered to for a long time and never wavered.

　　Adhering to the leadership of the Party is the fundamental guarantee for the rapid development of China’s space industry.

　　The most essential feature of Socialism with Chinese characteristics is the Communist Party of China (CPC)’s leadership, and the greatest advantage of Socialism with Chinese characteristics system is the Communist Party of China (CPC)’s leadership. Space cause is a great cause that concerns national security, shows national strength and embodies national will. As the main force to promote the development of China’s space industry, the establishment of the research institute is an important decision and strategic choice made by the CPC Central Committee to achieve breakthroughs in economic, national defense and scientific and technological construction in the poor and weak domestic environment. The CPC Central Committee has always attached great importance to the development of the space industry. From the beginning of the establishment of the space industry in 1956 to the present, every step forward and every leap in the development of China’s space industry cannot be separated from the wise decision-making and correct leadership of the CPC Central Committee.

　　At a time when new China is in full swing, the CPC Central Committee has made a decision to develop the space industry considering the country’s long-term development strategy. In 1958, Comrade Mao Zedong put forward that "we should also build artificial satellites", which started the journey of exploring space in China. At the beginning of the reform and opening-up, the CPC Central Committee approved the "863" high-tech research and development plan and made a major decision to develop the "New Samsung One Arrow". In the 1990s, manned spaceflight was carried out. In the 21st century, manned spaceflight and lunar exploration projects, Beidou satellite navigation system and high-resolution Earth observation system have been included in the national medium-and long-term scientific and technological development plan. Since the 18th National Congress of the Communist Party of China, the CPC Central Committee with the Supreme Leader as the core has attached great importance to the construction of a space power, demanding that we "make new contributions to the construction of a space power", which has opened a new chapter in China’s space industry.

　　History shows that the development history of China’s space industry is a struggle history of adhering to the leadership of the Party, firmly following the direction of the CPC Central Committee, and pushing the cause from victory to victory. Adhering to the party’s leadership is a unique advantage for the development of space industry, and it is also the fundamental guarantee for our brilliant achievements.

　　● Always adhering to the country-oriented value orientation is a solid cornerstone for the rapid development of China’s space industry.

　　General Secretary of the Supreme Leader pointed out that in the long history of the Chinese nation’s development for thousands of years, patriotism has always been the passionate theme and a powerful force to inspire people of all ethnic groups in China to strive for self-improvement. "Putting the country first" is a vivid manifestation of patriotism in China’s space cause. For the people in the institute, "putting the country first" means "serving the motherland with success and creating brilliance with Excellence", always insisting on putting national interests first and personal interests subordinate to national interests.

　　Looking back at the history, the development course of the Institute for more than 50 years is an epic of glorious struggle by generations of researchers, Do not forget your initiative mind, who strives for progress, values the country and dares to surpass it. In the initial stage of their career, the older generation of researchers, represented by Qian Xuesen, Yang Jiayuan, Wang Xiji and Sun Jiadong, returned to China with infinite love for the motherland, devoted themselves to the development of space, and turned China’s first artificial earth satellite — — Dongfanghong-1 was sent into space. During the period of social transformation, the people in the institute have been adhering to the belief of "I will do it if the motherland needs it", and have worked hard on their majors, laying a solid foundation for the rapid development of the space industry in the future. During the period of career development, the researchers unified patriotism, ambition to strengthen the country and the trip to serve the country, and explained the life creed of "serving the motherland with success and creating brilliance with Excellence" with practical actions.

　　History has proved that "putting the country first" is the unswerving choice of researchers. People in the institute consciously link personal ideals with the destiny of the motherland, personal choices with the needs of the country, and personal interests with the interests of the people. Adhering to the country-oriented value orientation is a solid cornerstone for the rapid development of China’s space industry.

　　● Adhering to the road of self-reliance and independent innovation is the only way for the rapid development of China’s space industry.

　　General Secretary of the Supreme Leader has repeatedly stressed that China must "adhere to the road of independent innovation with China characteristics" and "be determined to innovate independently, strengthen innovation confidence, and strive to enhance independent innovation capability." Key core technologies can’t be bought, bought or discussed. China’s space industry must take the road of self-reliance and independent innovation to build the country’s heavy weapon.

　　The development history of China’s space industry is a struggle history of self-reliance and independent innovation. During the development of the "Dongfanghong-1" satellite, the researchers were self-reliant, overcame numerous technical difficulties and created a solid "China thickness"; In the process of carrying out the manned spaceflight project, the researchers broke through and mastered the core technologies such as round-trip between heaven and earth, extravehicular space, rendezvous and docking, and on-orbit propellant replenishment, and constantly refreshed the "China speed" in the history of aerospace; During the construction of Beidou navigation satellite system, the researchers realized that the core technologies of on-board equipment such as atomic clock were in hand and 100% controllable, creating a perfect "China accuracy"; In the process of implementing the lunar exploration project, the researchers built the world’s first earth-moon relay communication satellite, realized the first soft landing on the back of the moon, and constantly refreshed the "China height" of deep space exploration; In the process of promoting the special project of high-resolution Earth observation system, researchers have broken through a series of major technical bottlenecks of high-resolution Earth observation, and supported the national people’s livelihood security with a steady "China span".

　　The road of independent innovation and development has been explored by generations of researchers in the long and arduous struggle. Adhering to the development path of self-reliance and independent innovation contains the deepest national endowment of the Chinese nation, which is the only way to climb the peak of world science and technology and the only way for the rapid development of China’s space industry.

　　● Always adhering to the scientific method of system engineering is the magic weapon for the rapid development of China’s space industry.

　　Spacecraft development is an extremely complex system engineering, which has the characteristics of great technical difficulty, high quality risk, many factors involved and complicated organization and management. Eliminating all difficulties to ensure success is the last word, and ensuring success has always been the eternal pursuit of researchers.

　　Over the past 50 years, the Institute has gradually established a scientific and perfect spacecraft development system based on system engineering theory. In the initial stage of the space industry, the Institute insisted on pre-research generation, development generation and production generation, and initially established the China spacecraft development management system. From the late 1970s to the mid-1980s, model development changed from project research to engineering development management. The Institute established a designer system and an administrative command system, and initially standardized the satellite development procedures. Since the middle and late 1980s, space technology has been fully applied to engineering, and the theory and practice of systems engineering have also entered a stage of all-round development. The Institute has carried out research and development contract management with technical and economic integration, and formed a series of systems engineering management ideas and methods.

　　Since the beginning of the new century, China’s space industry has entered a stage of rapid development, and the development of space technology has entered a critical period to achieve a major breakthrough. The number of annual launches and the number of aerospace models under research have hit record highs, which has brought great challenges to model research and production and quality management. The Institute systematically carried out the construction of three capacity projects, namely, "innovation leading", "aerospace intelligence building" and "quality improvement", and formed a scientific research and industrialization management mode of aerospace business in line with the concept of system engineering, as well as many effective scientific research and production management mechanisms and quality management rules and regulations, which laid a solid foundation for the smooth development of model development, continued to promote the transformation and upgrading of spacecraft development mode, and created a new chapter in the transformation and upgrading of China’s space research and production mode.

　　For decades, generations of researchers have always adhered to the scientific method of systems engineering, ensured the complete success of the model launch mission with scientific management methods and a high degree of vigilance, and promoted the steady development of the space industry. Adhering to the scientific method of systems engineering is the magic weapon for the rapid development of China’s space industry.

　　● It is an inexhaustible source for the rapid development of China’s space industry to always adhere to the strategy of strengthening the enterprise through talents and continuously inherit and carry forward the space spirit.

　　Behind every brilliant aerospace achievement, there are a large number of aerospace talents who love the motherland, selfless dedication and innovation.

　　The aerospace spirit is an important part of the Chinese national spirit and a powerful spiritual driving force for the leap-forward development of the aerospace industry. In the process of composing China’s space career for more than 50 years, the Institute has become an important birthplace of the traditional spirit of space, the spirit of "two bombs and one satellite" and the spirit of manned space flight. During the vigorous development of the space industry, the connotation of the space spirit pedigree has been continuously enriched, and the spirit of Beidou and the spirit of exploring the moon have been condensed and formed. They are the continuous enrichment, perfection and sublimation of the space spirit, which has injected more abundant model characteristics and era connotation into the space spirit pedigree.

　　The aerospace spirit has inspired generations of researchers to move from victory to victory. They have been deeply integrated into the blood and soul of the people in the institute, and they are a powerful spiritual driving force for the institute to make concerted efforts to promote the development of the space industry. It is with such a top talent team and brilliant aerospace spirit that the researchers can further overcome difficulties, persevere, keep their motivation and continue their struggle. We firmly believe that it is an inexhaustible source for the rapid development of China’s space industry to always adhere to the strategy of strengthening enterprises through talents and to always inherit and carry forward the space spirit.

　　2. Grasp the development direction of China’s space industry and accelerate the development of China from a space power to a space power.

　　The 19th National Congress of the Communist Party of China has comprehensively planned and deployed a grand blueprint for building a socialist modernization power and a world-class army by the middle of this century. The Institute will grasp the development direction of China’s space industry, Do not forget your initiative mind, keep in mind its mission, forge ahead into the future and continue to struggle, and lay a solid foundation for building China into a space power in 2045.

　　● improve the position, grasp the direction, and strive to create a new situation of the party’s overall leadership.

　　The research institute will further improve its political position, continuously strengthen its political and ideological construction, earnestly enhance the "four consciousnesses", strengthen the "four self-confidences" and achieve the "two safeguards", resolutely implement the instructions of the Supreme Leader General Secretary on the construction of a space power, engrave the party’s initial heart and mission in mind, and unite the vigorous forces for building a space power. To give full play to the leading role of the Party, the Party Committee of the Institute will resolutely implement the requirements of "two consistency", take the difficulties of reform as the focus of work, take the key of development as the foothold of work, persist in planning the future from the strategic height of building a space power, constantly study new changes and solve new contradictions, and earnestly shoulder the responsibility and burden of promoting the construction of a space power. Further deepen the comprehensive and strict administration of the party, constantly optimize the party building work system, compact the responsibility of managing the party, promote the grassroots party organizations to meet the standards, improve the supervision system, deepen the anti-corruption work, create a new situation in party building in the research institute, and provide a strong guarantee for promoting the development of space undertakings. Further strengthen the guarantee role of ideological and political work, carry out in-depth education on ideals and beliefs, effectively solve the concerns of employees, enrich the spiritual and cultural life of employees, give play to the role of matrix three-dimensional ideological and political work, create a strong atmosphere of "developing space industry and building a space power", and further strengthen the confidence and determination of building a space power.

　　● Be determined to study and think hard, and strive to create new glory in China’s space industry.

　　Major national projects have entered the critical period of implementation, and the task of developing and launching high-density aerospace models has become the new normal. In the face of major historical opportunities and severe challenges, the research institute will firmly build the belief of "pledging success and winning all the victories", advance layout, overall planning, scientific organization, and clear grasp, and go all out to complete the aerospace model tasks represented by major national projects and fulfill the mission of strengthening the country.

　　The research institute will go all out to complete major scientific and technological special construction tasks such as Beidou navigation global networking, the third-phase sampling return of the lunar exploration project, and the high-resolution Earth observation system; Make overall plans to promote the construction of space infrastructure and realize integrated and networked development; Build a near-earth orbit space station and realize its operational operation; Complete major scientific and technological projects of spacecraft on-orbit maintenance and service system; Realize the deep development and utilization of space resources, provide strong support for China’s industry voice and dominance in international space affairs, and strive to create new glory in China’s space industry.

　　● Driven by innovation and strengthened by new plans, we will strive to create new kinetic energy for the development of China’s space industry.

　　General Secretary of the Supreme Leader stressed that the aerospace industry should "persist in implementing the innovation-driven strategy, boldly innovate, be determined to reform, be down-to-earth and bravely climb the peak". The direction of some important fields of space technology in China is in a critical period of transformation from following the main direction to running and leading in more fields. We must keep a close eye on the world-class level and direction, face challenges directly and promote innovation and development.

　　The research institute will adhere to independent innovation, take the "innovation-led" project as the starting point, and focus on four aspects: strategic planning, system research, core specialty and application foundation to accelerate the improvement of innovation ability. Facing the country’s major strategic needs, we will continue to carry out strategic planning, deepen the road map demonstration of space powers, and accelerate the construction of a strategic planning demonstration system; Facing market competition, tackling key problems thoroughly and systematically, facing sustainable development, and accelerating the breakthrough of core professional technology; Focus on the long-term, strengthen applied basic research, constantly identify and cultivate subversive and intercepting cutting-edge technologies, lead the development direction of space technology, and grasp the initiative of space development.

　　● Reform and innovation, transformation and upgrading, and write a new chapter in the high-quality development of China’s space industry.

　　Comprehensively deepening reform is always on the road. As the backbone of the national space industry, the Institute will further clarify the strategic objectives and key measures, and further enhance its ability to "ensure success with high quality, complete tasks with high efficiency, and promote the construction of a space power and national defense with high efficiency". At the same time, the research institute will promote the transformation and upgrading of scientific research and production mode as a whole; Promote the establishment of a modern enterprise system with parent-subsidiary companies as the basic form, and complete the transformation of public institutions into enterprises; Grasp the overall requirements of high-quality development, strengthen risk management and prevention capabilities, continue to promote slimming and fitness, improve quality and efficiency, and improve management level; Adhere to the international development strategy, continue to expand market channels, promote international operation, and fully promote the high-quality development of space industry.

　　● Give priority to talents and cultural people, and promote the role of aerospace spiritual culture in casting souls to a new level.

　　The new era, new orientation, new mission and new goal call for a more outstanding talent team, a richer and better pedigree of aerospace spirit and a more powerful mechanism for ideological and political work.

　　The Institute will make great efforts to innovate and explore new ideas and methods to carry out ideological and political work, and take the theme education of "Do not forget your initiative mind, Keep in mind the mission" as an opportunity to further strengthen the ideals and beliefs of the cadres in the hospital. Efforts will be made to cultivate and practice socialist core values and continue to spread aerospace characteristic value concepts such as "focusing on the country". Efforts will be made to strictly implement the responsibility system for ideological work, firmly grasp the leadership and initiative of ideological work, and unite and lead the broad masses of workers to devote themselves to building a space power.

　　It is the concrete practice of the party’s initial heart and mission in the research institute to strengthen the belief of serving the country by space and the mission of strengthening the country by space, and it is also the responsibility of all the researchers! To build a space power, China Academy of Space Technology will thoroughly implement the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, grasp and follow the development law of China’s space industry, keep in mind Do not forget your initiative mind’s mission, continue to struggle for building a space power in an all-round way, and continue to write a new chapter on the journey of realizing the goal of "two hundred years" and realizing the great rejuvenation of the Chinese dream by the Chinese nation.

　　 (Author: Theoretical Learning Center Group of Party Committee of China Academy of Space Technology)

Special feature of 1905 film network Before the Double Eleven, domestic fans had entered the carnival mode.On October 29th, 2020, at the 20th National Cinema Domestic New Film Promotion Conference, more than 500 people gathered in Hengdian, Zhejiang, including 51 cinemas, over 50 film investment companies, distributors and production representatives. China Film, Huaxia, Bona, Wanda, Huayi and other upstream production companies have collectively promoted more than 100 outstanding domestic new films (including co-productions).

According to the information such as the promotion film list and the preparatory film list released by major film and television companies, it is accumulated that 262 new films will have or are expected to land in the cinema market in 2021. Among them, 242 films were made in China, accounting for 92.37% of the total, and 20 films were co-productions.

Movie Channel Merging Media, together with 1905 Movie Network and M Big Data, released the "2021 Cinema Foresight Report", and made a comprehensive inventory of 262 new films from the perspectives of film types, themes, IP and production companies.

What secrets will this report tell the audience behind the new film?

New films: plot, animation and comedy account for the largest proportion.

262 new films to be released, what state the progress bar is in, is one of the most concerned issues for the audience.

Judging from the current shooting progress, after rough statistics, there are 68 films in the preparatory stage, 112 films in the shooting and production stage, and 68 films have been completed and finalized. The proportion of new films in the shooting and production stage is the largest, reaching 42.75% of the whole.

Among the films that have been booked, at the 20th National Cinema Domestic New Film Promotion Conference, three relay films were booked for the Spring Festival in 2021, which pushed the market sentiment to a climax. The three films just correspond to animation, comedy and plot types respectively, which is highly consistent with the portrait data of the new film types to be released.

After counting the main elements of 262 new films to be shown, it can be found that the film list types cover 26 categories. Among them, the number of films with plot elements is 101, accounting for 22.1%, ranking first in the film genre. Animation and comedy genre films followed closely, reaching 47 and 45 respectively, accounting for 17.9% and 17.1% of the total.

The number of new animated films ranks second, which is closely related to the national craze caused by high-quality domestic animated films such as, and so on. The comedy film has always been one of the evergreen films in the world.

In the top ten genre films, except for the above three, the number of new films about action, suspense, love, fantasy and crime is above 30. In recent years, these types of films have not run away from many box office dark horses and have a certain audience base.

With more new films being produced and finalized, China audiences will have more choices on the big screen in 2021. For cinema managers, these new films also indicate that cinema revenue has a basic guarantee.

New trend: the main melody melody is in full bloom.　

In recent years, with the right climate and the right people, the main melody blockbuster has become the new favorite of the market.

,,, etc., organically integrated the theme of the times with commercial value, achieving a double harvest of box office and word of mouth. Facts have proved that the main melody blockbuster skillfully integrated with commercial elements is easier to be digested and absorbed by the audience.

Among the new films to be released in 2021, the theme film is still an important part worthy of attention. Among these films, there are not only the 100th anniversary of the founding of the Party, but also the theme of resisting US aggression and aiding Korea, as well as red classic films.

In addition to reviewing history, many main melody films follow the pace of the times, praising China spirit and carrying forward patriotic feelings. For example, Shenzhou, which is the theme of manned spaceflight, Doctor China, which tells the story of China people’s war and epidemic, and China Flight Tester, which tells the story of China’s "test hero" Li Zhonghua, etc.

There are more realistic works based on real people and story prototypes. For example, the economic investigation film adapted from the "Fox Hunting Action" of the Ministry of Public Security, the story about the Jedi rescue of the frontier armed police, and the theme of getting rid of poverty.

Since the summer file in 2018, after the upsurge of realistic works was started, the strong sense of substitution and resonance of such works are more likely to give birth to box office dark horses and are more favored by capital. In 2021, the realistic works in the mainland film market are still at the peak of creation.

The market value of classic IP is reflected in many ways, such as sequels, adaptations and remakes. Among the 262 new films to be released, such as "manslaughter 2", etc., or will form a domestic series of films. Detective Chinatown 3, which will be released in the Spring Festival in 2021, has become one of the most concerned films in the sequel.

In addition, The Order of the Gods, which is based on the explosive mobile game IP, and The Blade of Wandering, which is based on the novel IP of Ghost Blowing Lights, remake the classic "Loyal Dog Eight Men" and other films with the same name, and it has been or is expected to be scheduled for 2021. Mature market awareness and broad audience base are important reasons why classic IP is popular in the market.

And Ne Zha have successively become explosions, which not only proves that the level of China’s film industry keeps pace with the times, but also sets off the creation fever of similar films.

At the 2020 China Science Fiction Conference held in early November, a set of data showed that under the leadership of The Wandering Earth, the total box office of domestic science fiction films reached 7,140.5 million in 2019, an increase of 212% compared with 2018. In the future, domestic sci-fi films such as "The Trilogy of Outer Space" directed by Chen Sicheng, supervised by Ning Hao and directed by Zhang Xiaobei will attract much attention from the market.

After the national cinemas resumed work in an orderly manner, the Opinions on Promoting the Development of Science Fiction Films jointly issued by the State Film Bureau and the China Association for Science and Technology strengthened the system construction of science fiction film production and personnel training from the policy level.

In terms of animated films, the new films to be released in the future are both young and adult. The series "Bears haunt", the permanent guest of the Spring Festival file, is the best choice for parents and children to watch movies. Adult-oriented animation, such as Phoenix and Nezha 2, adapted from classic fairy tales, shoulders the heavy responsibility of creating more glories for domestic animation.

It is worth mentioning that many domestic documentaries in the film list have international vision and production standards, and have certain box office potential. Directed by Jia Zhangke, after the world premiere of the special screening unit of the 70th Berlin International Film Festival, the audience gained online reputation. The first BRICS documentary film "Young People Without Borders" led by director Lu Chuan and the first water resource documentary "Zero Water Day" are all worthy of attention.

New mode: New and old film and television companies explore more cooperation modes.

The film and television circle has always been a vanity fair, and the participation of capital is indispensable behind many new films.

According to the current public information, a number of film and television production agencies have participated in the production and distribution of many new works. China Film Group, Huayi Brothers, WANDA CINEMAS and Enlight Media have exposed more than 20 reserved films respectively. By participating in the statistics of the number of projects, it is not difficult to find that the traditional film and television companies in the head are still in the leading echelon, and the new Internet film companies have grown into the backbone.

WANDA CINEMAS and Huayi Brothers, as the "big brothers" in the industry, give full play to the advantages of resource integration, not only participate in the production of Spring Festival blockbusters such as Detective Chinatown 3 and The Order of the Gods, but also actively arrange online film and television services such as online movies and online dramas, and actively explore more production modes and revenue channels.

As representatives of Internet film companies, Alibaba Pictures, Cat’s Eye Film and Tencent Film have an average reserve of more than 15 films. In the past, the lack of master explosion movies has become a collective pain point for Internet film companies. Nowadays, with the resources and experience accumulated by deep participation in publicity and development, these companies are testing water more and more times.

In addition to the increasing number of master works, the types in the company’s film list are more and more diversified, and both commercial expression and author’s style are equally important, which has become one of the content characteristics of Internet film companies participating in film production. At the beginning of the announcement, these companies took advantage of big data and launched more new models.

There are more and more cases in which traditional film companies and Internet film companies strengthen cooperation and give full play to their respective advantages. For example, among the producers of 1921, Fox Hunting, and other films, there are both traditional and Internet studios. In addition, new cross-border forces, represented by POP MART cultural and creative companies, are increasingly appearing among new film investors.

In the creation of big-screen works, besides the blessing of capital, the participation of filmmakers is essential. Judging from the creative information of new films to be released in 2021, many heavyweight filmmakers are active in all aspects of film creation.

Among them, three directors, Ning Hao, Jia Zhangke and Wu Ershan, all participated in the creation of five films. Their identity, from director to producer to actor, can be described as omnipotent. The change of different identities can also see the help of mature directors for the younger generation.

Among these films to be released, M Big Data sorts out the ten works that are most expected by netizens. Among them, six films, such as Detective Chinatown 3, Japanese and Korean, have been booked for the Spring Festival in 2021.

Detective Chinatown 3 ranks first in the M-fever list of 8 works scheduled for the Spring Festival next year, followed by The Rescue and Boonie Bears:The Wild Life. According to previous market experience, Detective Chinatown 3, which has the highest popularity before the screening, will lead the box office competition for the Spring Festival. Whether this film can break the curse of "the front runner can’t be the total box office champion" is worthy of attention.

In the future, 262 new films will meet the audience one after another. The collective booking and release of these new films indicates that the China film market has recovered its former vitality and will create more glories.

Original clinical nutrition network

Author: Plain dust-free

Postdoctoral fellow, University of California San Diego Cancer Center. Nutritionist, food safety engineer

Washington University in St Louis, graduate student in public health, pre-medical doctor. Doctor of Public Health from Louisiana State University Health Sciences Center, and Delta Omega Doctoral Award, one of the highest honors of American public health graduates. "China Clinical Nutrition Network" signed a dietitian

His main research interests are smoking cessation, alcohol withdrawal and marijuana withdrawal, nutrition and chronic diseases, and cancer prevention and control.

The article was first published in big doctor magazine, and was revised by the author and then pushed again.

China Clinical Nutrition Network has been authorized to reprint

Nutrients are various substances needed by the human body, which support the growth, development and normal physiological functions of the human body. The nutrients needed by the human body can be roughly divided into seven categories. In the past, we used 15 issues to introduce the physiological functions, excess and deficiency, food sources and hot topics of seven nutrients in detail.

The following is a brief summary of them and a link to introduce each nutrient in detail (click the title to enter directly):

General introduction

The first issue:

(Image from WeChat public platform public photo gallery)

1. protein

An important component of the human body, used to repair and build body tissues, is also the main component of enzymes, hormones and antibodies. Protein is rich in meat, eggs, beans, nuts and seeds.

Phase II:

(Image from WeChat public platform public photo gallery)

2. Fat

Provide energy for the body and help absorb fat-soluble vitamins. It includes saturated fat, monounsaturated fat and polyunsaturated fat. Healthy sources of fat include fish, nuts, seeds and olive oil.

The third issue:

(Image from WeChat public platform public photo gallery)

3. carbohydrates

The main energy source of the human body. It includes sugar, starch and fiber. Whole grains, vegetables, fruits and beans are good sources of carbohydrates.

Phase IV: Phase V:

(Image from WeChat public platform public photo gallery)

4. vitamins

Nutrients that the human body cannot make by itself and must obtain from food or supplements. They contribute to various physiological functions of the body, including immunity, vision and bone health. Vitamins are mainly obtained by eating fresh vegetables, fruits and whole grains.

Issue 6: Issue 7: Issue 8:

(Image from WeChat public platform public photo gallery)

5. minerals

It is very important for bone health, muscle function, nerve conduction and some biochemical reactions. Foods rich in minerals such as fresh vegetables, fruits, whole grains, nuts and seeds.

Issue 9: Issue 10: Issue 11: Issue 12:

(Image from WeChat public platform public photo gallery)

6. Dietary fiber

Although they are not absorbed by human body, they have many health benefits, including improving digestion, preventing constipation, controlling blood sugar and reducing the risk of heart disease. Dietary fiber mainly comes from vegetables, fruits, whole grains and beans.

Issue 13:

(Image from WeChat public platform public photo gallery)

7. Water

The main component of the human body is vital to the functions of all body systems, including temperature regulation, waste removal and transportation of nutrients.

Issue 14: Issue 15:

(Source: WeChat public platform public photo library)

Attachment: Nutritional catering

Why do people eat so many kinds of food every day? Because the body needs balanced nutrients! Every food contains different nutrients, so we need to take them from different foods. Generally, weight catering method and energy catering method can be used.

Issue 16: Issue 17: In the next series, we will use 10 issues to introduce nutrition and health in different life cycles, including the potential impact of newborn birth weight on health, eating and sleeping of babies, health and nutrition needs of children and adolescents, and nutrition needs and health management in early, middle and late adulthood. Regarding the life cycle, if you have any special topics you want to know, please leave a message.

Original title: "[Popular Science Nutrition] A summary of the seven nutrients and nutritional meals that the human body needs! 》

Read the original text

Percutaneous argon-helium knife treatment of liver cancer is one of the non-surgical treatment methods in recent years, which indicates that the treatment of liver cancer has entered a new stage of cryotherapy. Professor Yang Yongping, director of the Department of Hepatology and Medicine, Fifth Medical Center, General Hospital of Chinese People’s Liberation Army, shared the cryoablation treatment of liver cancer in the first multi-disciplinary cooperation forum of Anhui Province, and the platform of treating liver cancer with sincerity specially compiled the essence for readers.

Overview of liver cancer

In China, hepatocellular carcinoma (HCC) is the fifth largest malignant tumor and the second largest tumor-related death cause, with a five-year survival rate of only 14.2%. How to treat liver cancer scientifically and benefit the long-term survival of patients is an important clinical problem, and it is also the gold standard to measure the treatment level of medical units. In 2022, the updated guidelines for prognosis and treatment strategy of clinical liver cancer (BCLC) in Barcelona proposed that patients with HCC should be accurately evaluated individually. Doctors need to fully consider the scope and load of the tumor, the nutritional status and human performance of the patient, complications, age, etc., and formulate individualized treatment methods for the patient.

No matter what stage the patient is in, local ablation is an important treatment. At present, a variety of mature local ablation treatment techniques for liver cancer have been formed, including radiofrequency ablation, microwave ablation, cryoablation, irreversible electroporation (nano-knife) and so on.

Overview of cryoablation therapy

Cryoablation therapy has experienced a long development process. In 1800, James Arnott discovered that the mixture of ice and salt could delay the progress of breast cancer, uterine cancer and skin cancer. In 1950, liquid nitrogen and dry ice were used to treat different kinds of diseases, especially benign skin lesions. In 1961, Cooper and Le introduced the first automatic cryosurgical equipment, but it used liquid nitrogen as refrigerant, which had many complications and was only used in laparotomy. In the 1970s and 1980s, liquid nitrogen needle was used to treat prostate hypertrophy and prostate cancer, but the cryoablation technology was stagnant due to many complications. In the 1990s, intraoperative ultrasound monitoring of freezing process was used in surgery by scholars, and argon was studied as the refrigerant. In 1998, the third generation cryosurgery system (Argon-Helium cryosurgery system) came out in the United States, which used argon as the refrigerant and helium as the heat medium, bringing revolutionary progress to minimally invasive cryosurgery. In 2000, cryotherapy entered American medical insurance. In 2003, the World Congress of Targeted Cancer Therapy recommended cryoablation as the first choice for advanced lung cancer and liver cancer. In 2010, the standardized diagnosis and treatment of liver cancer promoted by the Health Planning Commission listed cryoablation as a local treatment for liver cancer. In 2016, after more than 10 years of unremitting efforts, Professor Yang Yongping’s team led the overall and comprehensive innovation and development of percutaneous cryoablation of liver cancer at home and abroad, changed the international prejudice on cryoablation of liver cancer, turned the small path into the big road, the irregular into the norm, and the unpopular into the hot spot.The technological innovation of cryoablation of liver cancer won the first prize of Beijing Science and Technology Progress Award. In 2018, 2019 and 2020, experts’ consensus on imaging-guided cryoablation for lung cancer, experts’ consensus on imaging-guided cryoablation for bone and soft tissue tumors, experts’ consensus on imaging-guided cryoablation for kidney cancer and experts’ consensus on imaging-guided cryoablation for liver cancer were released respectively. So far, NCCN, AASLD, APASL, EASL and other guidelines have recommended cryoablation for the treatment of primary liver cancer.

At present, the Department of Hepatology Medicine of the General Hospital of the Chinese People’s Liberation Army has become the largest medical center for treating liver tumors in the world last year, constantly exploring the innovation of cryoablation technology, adopting high-vacuum heat insulation technology, only destroying the tumor site without damaging the surgical path, and adopting multi-stage heat exchange technology, which makes the refrigerant utilization rate higher and the cooling rate faster, and it is easier to induce the frozen immune response of liver cancer patients, activate their own anti-tumor immunity and produce ectopic tumor inhibition.

Therapeutic mechanism and characteristics of cryoablation technology

The cryoablation area is composed of central coagulative necrosis area and peripheral tissue injury area with different degrees. The mechanism of rapid direct cell necrosis in the central area includes mechanical damage caused by ice crystal formation inside and outside the cell and osmotic damage caused by dehydration and rupture of the cell. Peripheral injury areas are mainly related to freezing-related secondary injuries, including hypoxia death of tumor tissue caused by blood embolism, apoptosis caused by reversible injury, and waterfall-like ectopic tumor suppression by stimulating immune regulation.

The characteristics of cryoablation technology include: ① clear treatment boundary, real-time monitoring under image, safe and reliable treatment; ② Treatment can stimulate human immunity and strengthen tumor treatment; ③ Physical therapy is non-toxic to human body, with extremely low side effects; ④ The treatment is painless, without general anesthesia and participation of anesthesiologists, and the treatment is convenient; ⑤ Not limited by the artificial pacemaker installed in the body; ⑥ Effective, suitable for lung cancer, liver cancer, kidney cancer, breast cancer, prostate cancer and other solid tumors.

In addition, ultrasound, CT, laparoscopy or intraoperative direct vision guidance can be used for cryoablation treatment, and the tumor position and the formation of ice hockey can be monitored in real time.

Current situation of percutaneous cryoablation of HCC

Before 2005, based on the previously reported clinical research results, there were many complications, such as bleeding, liver parenchyma frost crack, freezing shock, coagulation dysfunction and so on. International scholars were cautious about this technology. After 2005, percutaneous cryoablation for liver cancer has developed in China, especially with the publication of China’s continuous clinical summary and high-level evidence in the top international journal Hepatology. More and more clinical studies have confirmed that percutaneous cryoablation for liver cancer is safe and effective, and international scholars have a positive attitude.

Professor Yang Yongping’s team took the lead in conducting clinical research to determine the indications of liver cirrhosis-related HCC by percutaneous cryoablation. In this study, 1681 patients with liver cirrhosis-related HCC and 682 patients with advanced HCC were selected, and the indications and standards of complete cryoablation and selective cryoablation were established. It was proposed that the ablation volume of the target lesion should exceed 50% of the tumor volume or minimize the tumor load, relieve the symptoms caused by the tumor, improve the quality of life and prolong the survival time. The study also innovatively changed the percutaneous puncture to guide needle to locate the introduction of vascular sheath to solve the problem of bleeding after cryoablation, which has been cited by foreign counterparts for many times and suggested routine application.

Indications for complete cryoablation of liver cancer:

① The maximum diameter of a single tumor is less than 5 cm, or the number of tumors is less than 3, and the maximum diameter is less than 3 cm;

② Recurrence after surgical resection or other local treatment meets the conditions ①;

③ Child-Pugh A or B of liver function, bilirubin level ≤51.3μmol/L, or reaching this standard after medical treatment;

④ The blood coagulation function is good (prothrombin activity > 40%, platelet count > 30×109//L, using sheath hemostasis and packing system);

⑤ECOG PS ≤2；

⑥ Cirrhosis, including a history of chronic liver disease, with enlarged hepatic fissure/metacentric colon/esophageal varices/gastric varices/serrated liver surface, a history of upper gastrointestinal bleeding or ascites, and platelets < 100×109/L..

Indications for selective cryoablation of liver cancer:

① Single tumor with a maximum diameter of > 5cm or multiple tumors with a maximum diameter of > 3cm that cannot be surgically removed, regardless of whether there is tumor thrombus in portal vein;

② Child-Pugh A or B liver function classification, bilirubin level ≤51.3μmol/L or reaching the standard after medical treatment;

③ The blood coagulation function is good (prothrombin activity > 40%, platelet count > 30×109/L, using sheath hemostasis and packing system);

④QECOG PS ≤2；

⑤ Cirrhosis, including a history of chronic liver disease, with widened hepatic fissure/metacentric colon/esophageal varices/gastric varices/serrated liver surface, a history of upper gastrointestinal bleeding or ascites, and platelets < 100×109/L..

In addition, Professor Yang Yongping’s team innovatively established measures to prevent and treat complications of percutaneous cryoablation of hepatocellular carcinoma. In this study, 3321 patients were selected, and the measures of percutaneous cryoablation of liver cancer complications were established and verified (Table 1).

Table 1 Measures for Complications of Percutaneous Cryoablation of Liver Cancer

Moreover, the study has achieved encouraging clinical results, which increased the complete tumor ablation rate by 10.6%, reduced the local tumor recurrence rate by 30.3% in 5 years, and improved the 5-year survival rate by 16.6%.

Advantages of cryoablation in the treatment of hepatocellular carcinoma

Although cryoablation has distinct advantages over radiofrequency ablation (RFA), there is no RCT study in the past to directly compare the efficacy of ablation of liver cancer, especially the safety. Professor Yang Yongping’s team designed RCT study in five years to evaluate the efficacy and safety of percutaneous cryoablation and radiofrequency ablation of liver cancer. For the tumor, there were statistical differences in the local tumor progression rate between the two groups at 1, 2 and 3 years: 3%, 7% and 7% in the frozen group, respectively; The RF group was 9%, 11% and 11% respectively (P = 0.043). Subgroup analysis: For hepatocellular carcinoma with a diameter of > 3cm, cryoablation has a lower local tumor progression rate (cryoablation vs. RF: 7.7% vs. 18.2%, P=0.041). There was no statistical difference in the local tumor progression rate between 1-2cm (frozen vs. RF: 0% vs.2.4%, P=1.000) and 2.1-3.0cm (frozen vs. RF: 4.1%vs.7.1%, P=0.656). The results were published in Hepatology magazine and also in China.

Professor Yang Yongping’s team also confirmed that cryoablation of HCC can produce ectopic tumor inhibition, with the incidence of ectopic tumor inhibition of 6.3%, and the median survival time of patients with ectopic tumor inhibition was significantly prolonged. The mechanism is related to the down-regulation of PD-1/PD-L1 and regulatory T cells after ablation. In addition, argon-helium cryotherapy is effective for elderly HCC.

Unresolved problems in cryoablation of HCC

There are also many problems to be solved in the process of cryoablation for HCC in the future:

1. Does tumor cell ablation release specific tumor cell death signal?

2. How can freezing produce the best ratio of necrosis and apoptosis?

3. Are the cytokines released after freezing derived from tumor microenvironment or natural immune response, and what is their time sequence?

4. Will the functional essence and time sequence of antigen presenting cells that absorb necrotic tissue change after cryoablation?

5. What is the effect of cryoablation and absorption of necrotic tissue on the immunosuppressive function of the body? How to reduce the immunosuppression of the body?

Expert introduction

　

Professor Yang Yongping.

Chinese people’s liberation army general hospital No.5 medical center

Director, Department of Hepatology and Medicine, PLA General Hospital

Chief physician, professor, doctoral tutor

Silver Star of Science and Technology of the General Logistics Department, winner of special allowance of the State Council

Chairman of the Professional Committee of Liver Diseases of China Research Hospital Association

Director of China Hepatitis Foundation

Director of China Research Hospital Association

Vice Chairman of Liver Disease Professional Committee of Beijing Branch of Chinese Medical Association

Vice Chairman of Liver Disease Professional Committee of Beijing Society of Integrated Traditional Chinese and Western Medicine

Take the lead in the major special topics of the "Thirteenth Five-Year Plan and Twelfth Five-Year Plan" of the country, the key topics of the "Twelfth Five-Year Plan" of the army and the key topics of the Beijing Municipal Science and Technology Commission in integration of defense and civilian technologies; Won one national science and technology progress award, one first prize of Beijing science and technology progress award and six second prizes of military science and technology progress award.

Finishing/platform review/Professor Yang Yongping

This article is only for medical and health professionals to understand information, and does not represent the views of this platform. This information cannot replace professional medical guidance in any way, nor should it be regarded as medical advice. If the information is used for purposes other than understanding the information, the platform and the author shall not bear the relevant responsibilities.

　　CCTV News:According to the WeChat official account news released by Shanghai, the Shanghai Central Meteorological Observatory issued a blue rainstorm warning signal at 12: 30 on August 23rd, 2023: Due to the influence of strong precipitation clouds, it is predicted that there will be precipitation in parts of central and southern Shanghai with a cumulative rainfall of more than 50 mm in six hours before midnight today. Please pay attention to the prevention of urban waterlogging caused by heavy rainfall, and do a good job in drainage and waterlogging prevention in low-lying and flood-prone areas.

　　The yellow warning of lightning issued before is still high.

　　Defense guide:

　　1. Stop carrying out outdoor activities in open places.

　　2. Stop swimming in rivers, lakes and seas.

　　3. Stay away from trees, corners or places with prominent metal objects; Don’t hold objects with sharp metal corners in your hands or carry them on your shoulders.

　　Defense guide:

　　1. Citizens should prepare rain gear to ensure safety.

　　2, drivers pay attention to the road water.

　　Level Ⅳ response of flood prevention platform

　　According to the introduction of the Municipal Flood Control Office, the level IV (level IV) response of the city’s flood control stations started simultaneously.

　　Level 4 (IV) emergency response (blue)