Therefore, Song Jia’s styles in the film were designed by the director Jianqi Huo himself. "Many people may suddenly realize that the style of the Republic of China can still be dressed like this after watching Xiao Hong. In fact, Xiao Hong is the fashion pioneer of the Republic of China. As a well-known Shanghai writer, she is the trend leader. Even now, her dress is still very popular. Whether it is a young literary woman or a white-collar woman in the workplace, Xiao Hong’s single items can be used. " Some netizens who have seen the stills in advance laughed and said: "It is estimated that the same paragraph will be popular in Taobao!"
　
　　　 Song Jia bluntly said, "Xiao Hong" is the most exquisite costume collocation he has ever encountered since filming. "The director is very demanding. He hopes that every detail can reflect Xiao Hong’s feelings. We have been choosing clothes, and we must be beautiful enough and literary. We must reproduce Xiao Hong in the original way. Xiao Hong’s literature and art in his heart are colored." The hard work of the director and the staff was not in vain. "Xiao Hong has been wandering from place to place all her life, suffering from poverty and illness. No matter how poor and hungry she is, she will let herself go out gracefully.The biggest feeling of 18 models for me is that they can guide me to enter the state of Xiao Hong quickly. "

Next page: Song Jia: Xiao Hong is the real literary young woman.

Since Kunqu Opera was selected into UNESCO’s "Representative Works of Oral and Intangible Heritage of Humanity" in 2001, the government-led protection of intangible heritage in China has gone through 17 years. Although China’s intangible cultural heritage protection has not been carried out for a long time from an international perspective, with the great attention of the CPC Central Committee and the State Council, and the joint efforts of cultural administrative departments at all levels and all walks of life, China’s intangible cultural heritage protection has made rapid progress and achieved fruitful results, which not only created a vivid situation for the inheritance and development of intangible cultural heritage in the contemporary era, but also provided many methods and measures for the international community with China experience.

Establish rules and regulations, and build an intangible cultural heritage protection system.

In order to comprehensively understand and master the species, quantity, distribution, survival and inheritance of intangible resources in various regions and ethnic groups, from 2005 to 2009, China launched the first nationwide survey of intangible resources, and the total number of intangible resources was nearly 870,000. On this basis, China has established a national, provincial, municipal and county-level intangible cultural heritage list system. Up to now, the State Council has approved and published 4 batches of 1,372 national representative projects, and 15,550 provincial and municipal representative projects have been approved and published by various provinces, autonomous regions and municipalities. The former Ministry of Culture identified 4 batches of 1,986 national representative inheritors, and 14,928 provincial and municipal representative inheritors were identified by all provinces, autonomous regions and municipalities. China has been selected into UNESCO’s list of intangible cultural heritage projects, reaching 39, ranking first in the world.

In 2011, China promulgated and implemented the Intangible Cultural Heritage Law of People’s Republic of China (PRC). The promulgation of this law is a milestone, which provides a solid legal guarantee for the protection of intangible cultural heritage in China. The former Ministry of Culture has successively issued regulations on the protection and management of non-legacy representative projects, the identification and management of representative inheritors, the management of special funds, and the construction and management of cultural and ecological protection zones. By the end of 2017, 26 provinces, autonomous regions and municipalities across the country had promulgated regulations on the protection of intangible assets.

With the deepening of understanding, China proposes to protect the intangible cultural heritage and the environment where it breeds and develops. Since the establishment of Minnan Cultural and Ecological Protection Experimental Zone in 2007, China has successively set up 21 national cultural and ecological protection experimental zones in areas with concentrated non-legacy projects, distinctive features and complete contents and forms, and strived to promote each experimental zone to become a cultural and ecological zone with rich heritage, strong atmosphere, distinctive features and benefits for the people.

Carry forward and improve the practical ability of inheritance.

On the basis of continuous improvement of the intangible cultural heritage protection system, in recent years, the former Ministry of Culture put forward three important concepts: "protection in improvement", "intangible cultural heritage entering modern life" and "seeing people, seeing things and seeing life". A series of work focusing on the protection of inheritance practice, inheritance ability and inheritance environment has been carried out, which has brought intangible cultural heritage back to life and revived its vitality in contemporary production and life.

The work of intangible cultural heritage records is a basic work of intangible cultural heritage protection. Since the 18th National Congress of the Communist Party of China, the former Ministry of Culture has carried out non-legacy rescue records on the basis of previous investigation records, and gradually summed up experience and expanded and established the non-legacy record project. By the end of 2017, the central government had supported the rescue recording of 839 national representative inheritors, and the unique skills and cultural memories carried by a group of representative inheritors were recorded and preserved.

Traditional arts, traditional skills and traditional medicine and drug processing are intangible items, which are originally produced in production practice, and their cultural connotation and technical value are reflected by the production process, and the general public share their charm by owning and consuming materialized products or works of traditional skills. In view of this type of intangible cultural heritage projects, China puts forward the concept of "productive protection" to encourage and support the inheritors to actively resume production and truly realize live transmission.

In order to further promote the inheritance and revitalization of traditional crafts and expand the contingent of non-genetic inheritors, in 2015, the former Ministry of Culture and the Ministry of Education launched the training program for non-genetic inheritors in China. By the end of 2017, a total of 48,000 people had established self-confidence, been inspired and enhanced their abilities through research and training; The excellent works and rich products created and produced by the students fully show the great energy that can be generated after the creativity and imagination of the vast number of people are released.

In order to explore effective measures to revitalize traditional crafts, since March 2016, the former Ministry of Culture has supported relevant enterprises, universities and institutions to set up 10 traditional craft workstations in traditional craft gathering places, involving embroidery, wood carving, lacquer art, metal forging, traditional residential building skills and other categories. Up to now, Hami Station in Xinjiang, Xiangxi Station in Hunan, Leishan Station in Guizhou, Guoluo Station in Qinghai and Huangshan Station in Anhui have developed more than 1,000 kinds of practical products that have entered modern life, effectively promoting the creative transformation and innovative development of traditional crafts.

Accurate poverty alleviation, from "fingertip skill" to "fingertip economy"

Through productive protection, on the one hand, traditional crafts are carried forward, on the other hand, the income of the masses is increased and the poor people are helped out of poverty. Some inheritors said that "fingertip skill" has really been transformed into "fingertip economy".

In 2017, the former Ministry of Culture focused on supporting non-hereditary people in ethnic areas, remote areas and poverty-stricken areas to participate in the research and training program. Through training, the trainees not only improved their ability to inherit and practice, but also played a leading role in radiation. Take Qiandongnan Miao and Dong Autonomous Prefecture of Guizhou Province as an example. According to incomplete statistics, in the first half of 2017, only 225 students in this state participated in the research and training program, with the mode of "inheritor+cooperative/company+farmer", achieving an annual sales income of more than 750 million yuan. Excellent students returned to the local area to train new students and drive about 9,500 people to obtain employment, of which the poor accounted for 58% of the total employment, and each enterprise drove 47% on average.

Traditional process workstations have also played an important role in promoting precision poverty alleviation. In Hami, Xinjiang, 231 cooperatives and embroidery associations have been established, and more than 17,000 orders have been received. Nearly 1,000 embroidered mothers directly participated in the production of orders, with an average monthly income of 1,500 yuan per person. Hunan Xiangxi Workstation launched the "Let Mom Go Home" program to attract migrant women to return to their families by increasing the income of embroidered mothers. The workstation also negotiated 2,800 sets (pieces) of Miao embroidery orders with companies in Jinan, Shenzhen and other places, amounting to 500,000 yuan, which led to more than 160 rural women’s employment at home.

Spread communication and let excellent traditional culture shine on the world stage.

This year’s government work report proposes to carry forward Chinese excellent traditional culture and deepen cultural exchanges between China and foreign countries. As an important part of Chinese excellent traditional culture and a "living" heritage, intangible cultural heritage plays an important role in strengthening national cohesion and centripetal force and promoting exchanges and mutual learning between Chinese and foreign civilizations.

According to statistics, in the past five years, 320,000 exhibitions of intangible cultural heritage have been held nationwide, with 540 million people participating. A variety of intangible cultural heritage publicity and exhibition activities have comprehensively demonstrated the outstanding practical achievements of intangible cultural heritage protection in recent years, creating an atmosphere for the whole society to inherit and develop excellent traditional culture. The former Ministry of Culture made great efforts to promote the protection, inheritance and revitalization of intangible cultural heritage projects, and supported various localities to carry out a series of performance activities through activity guidance, repertoire mobilization, financial subsidies, dissemination and promotion, which improved the exhibition degree of intangible cultural heritage projects, increased the frequency of practice, and maintained and expanded the survival and development space of intangible cultural heritage projects.

In recent years, international exchanges and cooperation in the field of intangible cultural heritage have been deepening. China actively participates in the meetings of the Intergovernmental Committee for the Protection of Intangible Heritage and the formulation of relevant international rules, and draws on the theoretical methods and successful practices of other countries to provide China’s plan and China’s experience for the protection of intangible heritage in the world. UNESCO has established the Asia-Pacific World Heritage Training and Research Center and the International Training Center for Intangible Cultural Heritage in China. Through international training and exchange activities, these institutions have made important contributions to promoting the capacity building of relevant countries in the Asia-Pacific region for the protection of intangible cultural heritage.

China and Mongolia jointly declared Mongolian long-tune folk songs as masterpieces of human intangible cultural heritage, and cooperated in field investigation and protection of Mongolian long-tune folk songs; Carry out relevant exchange activities with Thailand, Japan and Britain on traditional crafts and intangible cultural heritage protection, laying a solid foundation for strengthening cooperation with foreign institutions in the field of intangible cultural heritage. In China, 35 overseas China cultural centers and 512 Confucius Institutes have been built, and intangible trainings such as Tai Chi and calligraphy have been well received, and traditional festivals and folk activities in China have been widely spread. (Reporter Wang Xuesi)

The renovation of old residential areas is a major livelihood project and development project. General Secretary of the Supreme Leader pointed out that the renovation of old residential areas is an important task to enhance people’s sense of gain, and it is also an important part of the implementation of urban renewal. The Community Construction Department of the Urban Construction Department of the Ministry of Housing and Urban-Rural Development (hereinafter referred to as the "Community Department") takes the transformation of old residential areas as the focus of doing practical things for the masses, and solves the "great livelihood" with "small incision" to continuously enhance the people’s sense of acquisition, happiness and security.

This year, this young team won the National Worker Pioneer. "The renovation of old residential areas is an important task to improve people’s quality of life, and it is a practical matter of people’s livelihood around the people. We are honored to be able to shoulder the heavy responsibility and win the honor, and we feel even more responsible. " Relevant comrades in the community office said.

Find out the base, pilot first, and clarify the direction of the transformation path

Most of the old residential areas were built before 2000. The construction standards of these residential areas are low, coupled with long-term neglect, incomplete municipal supporting facilities, aging houses and other outstanding problems. There are shortcomings in facilities, environmental supporting facilities and public services, which is far from the growing needs of the people for a better life. Residents have a strong willingness to transform. Old residential areas are large in quantity and wide in scope, and the task of renovation is heavy. How to promote renovation in a solid and orderly manner throughout the country?

Understanding what the masses think and expect, and learning from the grassroots is the first priority. The Community Department organized 20 departments and units to conduct in-depth research on 213 old communities in 93 cities and counties, and combed and analyzed the current situation, transformation needs and experience of old communities. Subsequently, Shandong and Zhejiang provinces and eight cities including Shanghai and Suzhou were organized to deepen the pilot projects, and special classes for joint work were set up with local comrades to jointly explore the establishment of nine mechanisms, such as mobilizing the masses to jointly build, sharing reconstruction funds and integrating and utilizing existing resources, and to "explore the road" in the reconstruction projects in detail, so as to accumulate experience for comprehensively promoting the transformation.

On the basis of comprehensive investigation and summing up the pilot experience, the Community Department took the lead in drafting the Guiding Opinions on Comprehensively Promoting the Renovation of Old Urban Residential Areas, which defined the target tasks and the scope of objects, established a package of support policies to meet the needs of renovation projects in terms of approval of renovation projects, taxation and finance, land and so on, basically formed the institutional framework for the renovation of old urban residential areas, and the renovation work was rapidly and comprehensively promoted throughout the country.

Guide the whole process and do a good job in deployment and implementation.

Since 2019, the country has started to renovate nearly 220,000 old urban communities, benefiting hundreds of millions of people. However, the larger new start-up tasks every year, coupled with the projects under construction, have brought great pressure to the streets and communities at the grassroots level. How to make the policy better adapt to the needs of the grassroots and land solidly?

The community department insists on keeping its eyes down, stepping down, throwing itself down and sinking into the front line, so that the policy can be passed on layer by layer from formulation to promotion to landing.

"The transformation of old residential areas is the initial intention and mission of this office. We are both policy makers and policy practitioners and implementers." Relevant comrades said.

According to reports, since 2019, the renovation of old residential areas has been included in the affordable housing project, and the General Office of the State Council has issued guidance. The Ministry of Housing and Urban-Rural Development, together with relevant departments, put forward targeted work requirements for the renovation work in that year according to the latest situation, tasks and objectives, and new situations and problems arising in the renovation, and made clear the "positive list" and "negative list" of work, so as to promote all localities to do their best and do their best to promote the renovation well and quickly.

With the gradual advancement of the renovation of old residential areas, the Community Department promptly answered questions about the difficulties encountered in various localities, followed up and summarized the deepening innovations in the implementation of policies in various localities, organized and printed seven batches of List of Replicable Policy Mechanisms for the Renovation of Old Urban Residential Areas, promoted the replicable experiences and practices in pioneering areas, guided all localities to learn from them, accelerated the improvement of working mechanisms and policy systems that meet the needs of renovation, and promoted the implementation of renovation policies.

For example, in order to solve the problem of "public needs and women need to face" in the transformation of old residential areas, the community department guides all localities to fully mobilize the masses to participate, ask for the needs of the people, ask for the people, ask for the benefits of the people, and seek the greatest common denominator of the transformation effect.

In the residents’ meeting hall of an old residential area in Qingdao, Shandong Province, a young cadre from the community office discussed the renovation plan of the residential area with the residents. Because there are many people in the surrounding primary schools during school hours, the residents are very concerned about the design plan of optimizing the internal traffic routes and getting through the fire exits. "Making policies and implementing them are different. Every old residential area has its own characteristics, and the needs of each resident are different. The renovation plan must be determined according to the wishes of residents and the actual situation of the residential area. In this process, it is very important to be with residents, want to be together, and be together. " The young cadre said with emotion.

Experience comes from grassroots practice and wisdom. The community department adheres to the typical demonstration and leads the way, and promotes the transformation process in various places with demonstration projects. Since 2021, the Community Department has identified a number of contact points communities every year, and adopted the methods of leaders’ efforts, young cadres’ on-the-spot investigation, and experts’ assistance to help the communities break the blocking points of renovation, create demonstration model projects, and share experiences and experiences with community cadres in the streets where various renovation communities are located throughout the country.

In order to evaluate the transformation work more scientifically and objectively, the community office has defined the measurement standard of the transformation work through performance evaluation, supervision and encouragement, so as to make the policy baton and the evaluation index system more unified. During the research and establishment of the National Statistical Investigation System for the Renovation of Old Urban Residential Areas, the Community Department, together with grassroots comrades, repeatedly studied the connotation of each statistical indicator in order to be accurate and efficient, focusing on the goal of timely and accurately reflecting the progress of the renovation and minimizing the statistical burden. "This set of statistical indicators has clear logic and strong pertinence, which is very helpful for guiding and promoting local work. The progress of the work can be clearly reflected in the statistics. Behind the figures are the transformation results that every resident can see and touch, and they are all tangible results. " A grassroots cadre responsible for the renovation of old communities said.

The central and local governments have resonated at the same frequency and exerted their strength in the same direction, overcoming difficulties and taking advantage of the situation. The policy implementation has not only not weakened, but the signal has become stronger and stronger.

Cooperate to fill the shortcomings and improve the supporting facilities

Living and working in peace and contentment is the simplest wish of China people. Residents spend most of their daily life, food, clothing, housing and transportation in the community. In order to do the "last mile" of serving the masses well, the Community Department cooperated with various departments Qi Xin to integrate resources and fill the shortcomings of facilities and services.

"what is missing, what to make up." The Community Office guides all localities to explore the working method of "physical examination before renovation", and before renovation, it conducts a thorough investigation of the facilities in the community, focuses on residents’ needs, adheres to goal orientation and problem orientation, adopts "menu-based" renovation, and makes precise efforts with "one district, one policy", giving priority to solving the urgent problems of the masses, using limited funds at the cutting edge and changing them into residents’ "hearts".

"Stick to the bottom line of safety" and focus on eliminating potential safety hazards. Accelerate the renovation of aging and hidden dangers of gas, water supply, heating, drainage, power supply, communications and other pipelines and pipelines, and put the concept of safe development throughout all links and the whole process of renovation.

"One old and one young" is the main concern of most families. The Community Department guides all localities to actively revitalize the housing and land resources in the community and surrounding areas, and add service facilities such as home care service centers, canteens for the elderly and children’s post stations according to local conditions. In conjunction with the State Sports General Administration, the "national ball into the community" campaign was launched, and small sports and fitness facilities such as table tennis tables were added for old communities to allow residents to move at their doorsteps.

In recent years, residents have a high voice for installing elevators in existing houses, and the community department has faced up to the difficulties of reaching a consensus and raising funds, and adhered to the combination of rule of law and rule of virtue to help solve the problem of "it is difficult for suspended elderly people to go downstairs". Seize the favorable opportunity when the National People’s Congress promulgated the law on barrier-free environment construction, and promote national legislation to support the installation of elevators in existing multi-storey houses in old urban communities. Give play to the role of grassroots organizations in street communities, take party building as the guide and residents’ consultation as the basic working methods, and promote residents to reach a consensus. In conjunction with the Supreme People’s Court, a typical case was issued to guide residents to correctly understand the legal provisions applicable to installing elevators, and to carry forward the traditional virtues of the Chinese nation, such as being good neighbors and helping each other.

Great cause inspires people to forge ahead. The achievements made by the Community Office courageously come from the broad masses of the people’s support for the major decision-making arrangements of the CPC Central Committee and the State Council, and also reflect the hope of millions of grassroots community workers and community residents to work together to build a beautiful home.

April 27th

Xiaomi ecological chain enterprise

Ningbo qingmei electrics technology co., ltd

"Intelligent Manufacturing Project of Millet Dishwasher"

Sign a contract to settle in Zhangjiagang High-tech Zone

The total investment of the project is 500 million yuan.

This cooperation will give full play to the advantages of both sides in the field of intelligent manufacturing and innovation ecology, inject strong kinetic energy into regional industrial upgrading, and create a new benchmark for the smart home appliance industry in the Yangtze River Delta.

Xiaomi Dishwasher Intelligent Manufacturing Project signed a contract to settle in Zhangjiagang.

Intelligent manufacturing project of Xiaomi dishwasher

The land area is about 35 mu.

The total construction area is about 60,000 square meters

Relying on the core technical advantages of Qingmei Electric in the field of smart dishwashers, the project combines the innovative resources of Xiaomi ecological chain and the industry accumulation of gold medal home, focuses on the integrated research and development of cabinets and electricity and the expansion of smart kitchen scenes, and is committed to building a digital factory integrating design, production and sales.

Effect drawing of intelligent manufacturing project of millet dishwasher.

According to reports, the project will mainly build

3 intelligent dishwasher production lines, injection molding workshop,

Sheet metal workshop, intelligent warehouse,

Digital national laboratory, etc.

The main products are desktop series, full-size embedded dishwasher series, full-size embedded dishwasher series and so on. It is planned to produce 500,000 intelligent dishwashers annually. After the project is put into production, it is estimated that the annual output value will be 800-100 million yuan.

Xiaomi intelligent dishwasher product map.

As the sole partner of Mijia Dishwasher’s new platform, Qingmei Electric Appliance is a national high-tech enterprise and the drafting unit of the national standard of "Performance Test Method for Household Electric Dishwashers", with nearly 200 technical patents for dishwashers in four years.

In 2023, Qingmei Electric signed a three-year strategic cooperation agreement with Xiaomi Communication Technology Co., Ltd., and reached a strategic cooperation R&D agreement with Jinpai Kitchen Cabinet Home Technology Co., Ltd. in the same year to jointly lay out digital smart kitchens and build an integrated product platform for cabinets and electricity. At present, the products of Qingmei Electric include a full range of dishwashers, a kitchen center with integrated cabinet and electricity, and other emerging kitchen appliances. Leading the industry in the core technologies of dishwashers, such as integration of consumption and storage, intelligent delivery of dishwashing liquid, washing and drying.

Except for the millet dishwasher

Recently, many intelligent manufacturing projects have settled in Suzhou.

In order to speed up the construction of modern production system

Cultivate and develop new quality productivity and help bring in new kinetic energy

On April 27th, Wuzhong Taihu New Town Investment Promotion Project was signed. Eight innovative projects with a total investment of 3.2 billion yuan were signed and settled in Wuzhong, covering emerging fields such as intelligent travel and home service robots.

The eight projects are the intelligent high-end scooter, the unbounded high-end electric motorcycle, the high-end new energy tram of Jiexing Technology, the high-end new energy tram of Yuechuan Tuojing, the lawn mowing robot, the surge future swimming pool robot, the atomic remodeling 3D printing equipment and the R&D center of the clean-bound cruise window cleaning robot. Two of them are headquarters projects and six are R&D and production center projects. After the project is put into production, it is estimated that the output value will exceed 15 billion and the number of R&D personnel will reach 20,000.

Recently, a new project of Yangcheng Digital Valley Project in Jinjihu Business District of Suzhou Industrial Park was signed and settled. Among them, Suzhou Chineydy Intelligent Manufacturing Co., Ltd. signed a contract to build a new Yuanshu workshop. Chineydy Intelligent, a leading enterprise of artificial intelligence, integrates R&D, design and manufacturing, takes excellent engineering design R&D and software algorithm R&D as the strategic direction, and is committed to providing process solutions for global partners. Up to now, Chineydy Intelligent has won about 40 patents for inventions and utility models. The contracted area exceeds 15,000 square meters, which indicates that the enterprise will start a new journey in the field of intelligent equipment R&D and manufacturing.

As an important carrier of strategic emerging industries in Yangcheng Digital Valley Area, the newly-built Yuanshu Workshop focuses on frontier fields such as 5G+ industrial Internet, integrated circuits, medical devices and new materials, and takes the deep integration of "intelligence+industry" as the core to create an industrial demonstration zone of "changing intelligence from digital to network". The entry of Chineydy Intelligent will further strengthen the key link of the newly-built Yuanshu Workshop in the intelligent equipment industry chain.

On April 18th, brukner, the world’s leading machine and system manufacturer, signed a cooperation agreement with Suzhou Industrial Park Management Committee, and will invest 100 million US dollars to build its Asia-Pacific headquarters base integrating high-end manufacturing, R&D innovation, sales settlement and supply chain procurement in the park.

Brukner Group is a global leader in film stretching technology and one of the largest manufacturers of packaging machinery and equipment systems, providing large-scale high-end packaging production equipment and solutions for food, medical, automobile and daily consumer goods industries for a long time. This signing, brukner Group invested 100 million US dollars to introduce high-end film biaxial stretching equipment and solutions in the park, and build a comprehensive headquarters base integrating high-end manufacturing, R&D innovation, sales settlement and supply chain procurement. In the future, this headquarters base will become an important strategic hub for brukner Group to expand the Asia-Pacific market.

Original title: "Another project of Xiaomi settled in Suzhou! 》

Read the original text

Percutaneous argon-helium knife treatment of liver cancer is one of the non-surgical treatment methods in recent years, which indicates that the treatment of liver cancer has entered a new stage of cryotherapy. Professor Yang Yongping, director of the Department of Hepatology and Medicine, Fifth Medical Center, General Hospital of Chinese People’s Liberation Army, shared the cryoablation treatment of liver cancer in the first multi-disciplinary cooperation forum of Anhui Province, and the platform of treating liver cancer with sincerity specially compiled the essence for readers.

Overview of liver cancer

In China, hepatocellular carcinoma (HCC) is the fifth largest malignant tumor and the second largest tumor-related death cause, with a five-year survival rate of only 14.2%. How to treat liver cancer scientifically and benefit the long-term survival of patients is an important clinical problem, and it is also the gold standard to measure the treatment level of medical units. In 2022, the updated guidelines for prognosis and treatment strategy of clinical liver cancer (BCLC) in Barcelona proposed that patients with HCC should be accurately evaluated individually. Doctors need to fully consider the scope and load of the tumor, the nutritional status and human performance of the patient, complications, age, etc., and formulate individualized treatment methods for the patient.

No matter what stage the patient is in, local ablation is an important treatment. At present, a variety of mature local ablation treatment techniques for liver cancer have been formed, including radiofrequency ablation, microwave ablation, cryoablation, irreversible electroporation (nano-knife) and so on.

Overview of cryoablation therapy

Cryoablation therapy has experienced a long development process. In 1800, James Arnott discovered that the mixture of ice and salt could delay the progress of breast cancer, uterine cancer and skin cancer. In 1950, liquid nitrogen and dry ice were used to treat different kinds of diseases, especially benign skin lesions. In 1961, Cooper and Le introduced the first automatic cryosurgical equipment, but it used liquid nitrogen as refrigerant, which had many complications and was only used in laparotomy. In the 1970s and 1980s, liquid nitrogen needle was used to treat prostate hypertrophy and prostate cancer, but the cryoablation technology was stagnant due to many complications. In the 1990s, intraoperative ultrasound monitoring of freezing process was used in surgery by scholars, and argon was studied as the refrigerant. In 1998, the third generation cryosurgery system (Argon-Helium cryosurgery system) came out in the United States, which used argon as the refrigerant and helium as the heat medium, bringing revolutionary progress to minimally invasive cryosurgery. In 2000, cryotherapy entered American medical insurance. In 2003, the World Congress of Targeted Cancer Therapy recommended cryoablation as the first choice for advanced lung cancer and liver cancer. In 2010, the standardized diagnosis and treatment of liver cancer promoted by the Health Planning Commission listed cryoablation as a local treatment for liver cancer. In 2016, after more than 10 years of unremitting efforts, Professor Yang Yongping’s team led the overall and comprehensive innovation and development of percutaneous cryoablation of liver cancer at home and abroad, changed the international prejudice on cryoablation of liver cancer, turned the small path into the big road, the irregular into the norm, and the unpopular into the hot spot.The technological innovation of cryoablation of liver cancer won the first prize of Beijing Science and Technology Progress Award. In 2018, 2019 and 2020, experts’ consensus on imaging-guided cryoablation for lung cancer, experts’ consensus on imaging-guided cryoablation for bone and soft tissue tumors, experts’ consensus on imaging-guided cryoablation for kidney cancer and experts’ consensus on imaging-guided cryoablation for liver cancer were released respectively. So far, NCCN, AASLD, APASL, EASL and other guidelines have recommended cryoablation for the treatment of primary liver cancer.

At present, the Department of Hepatology Medicine of the General Hospital of the Chinese People’s Liberation Army has become the largest medical center for treating liver tumors in the world last year, constantly exploring the innovation of cryoablation technology, adopting high-vacuum heat insulation technology, only destroying the tumor site without damaging the surgical path, and adopting multi-stage heat exchange technology, which makes the refrigerant utilization rate higher and the cooling rate faster, and it is easier to induce the frozen immune response of liver cancer patients, activate their own anti-tumor immunity and produce ectopic tumor inhibition.

Therapeutic mechanism and characteristics of cryoablation technology

The cryoablation area is composed of central coagulative necrosis area and peripheral tissue injury area with different degrees. The mechanism of rapid direct cell necrosis in the central area includes mechanical damage caused by ice crystal formation inside and outside the cell and osmotic damage caused by dehydration and rupture of the cell. Peripheral injury areas are mainly related to freezing-related secondary injuries, including hypoxia death of tumor tissue caused by blood embolism, apoptosis caused by reversible injury, and waterfall-like ectopic tumor suppression by stimulating immune regulation.

The characteristics of cryoablation technology include: ① clear treatment boundary, real-time monitoring under image, safe and reliable treatment; ② Treatment can stimulate human immunity and strengthen tumor treatment; ③ Physical therapy is non-toxic to human body, with extremely low side effects; ④ The treatment is painless, without general anesthesia and participation of anesthesiologists, and the treatment is convenient; ⑤ Not limited by the artificial pacemaker installed in the body; ⑥ Effective, suitable for lung cancer, liver cancer, kidney cancer, breast cancer, prostate cancer and other solid tumors.

In addition, ultrasound, CT, laparoscopy or intraoperative direct vision guidance can be used for cryoablation treatment, and the tumor position and the formation of ice hockey can be monitored in real time.

Current situation of percutaneous cryoablation of HCC

Before 2005, based on the previously reported clinical research results, there were many complications, such as bleeding, liver parenchyma frost crack, freezing shock, coagulation dysfunction and so on. International scholars were cautious about this technology. After 2005, percutaneous cryoablation for liver cancer has developed in China, especially with the publication of China’s continuous clinical summary and high-level evidence in the top international journal Hepatology. More and more clinical studies have confirmed that percutaneous cryoablation for liver cancer is safe and effective, and international scholars have a positive attitude.

Professor Yang Yongping’s team took the lead in conducting clinical research to determine the indications of liver cirrhosis-related HCC by percutaneous cryoablation. In this study, 1681 patients with liver cirrhosis-related HCC and 682 patients with advanced HCC were selected, and the indications and standards of complete cryoablation and selective cryoablation were established. It was proposed that the ablation volume of the target lesion should exceed 50% of the tumor volume or minimize the tumor load, relieve the symptoms caused by the tumor, improve the quality of life and prolong the survival time. The study also innovatively changed the percutaneous puncture to guide needle to locate the introduction of vascular sheath to solve the problem of bleeding after cryoablation, which has been cited by foreign counterparts for many times and suggested routine application.

Indications for complete cryoablation of liver cancer:

① The maximum diameter of a single tumor is less than 5 cm, or the number of tumors is less than 3, and the maximum diameter is less than 3 cm;

② Recurrence after surgical resection or other local treatment meets the conditions ①;

③ Child-Pugh A or B of liver function, bilirubin level ≤51.3μmol/L, or reaching this standard after medical treatment;

④ The blood coagulation function is good (prothrombin activity > 40%, platelet count > 30×109//L, using sheath hemostasis and packing system);

⑤ECOG PS ≤2；

⑥ Cirrhosis, including a history of chronic liver disease, with enlarged hepatic fissure/metacentric colon/esophageal varices/gastric varices/serrated liver surface, a history of upper gastrointestinal bleeding or ascites, and platelets < 100×109/L..

Indications for selective cryoablation of liver cancer:

① Single tumor with a maximum diameter of > 5cm or multiple tumors with a maximum diameter of > 3cm that cannot be surgically removed, regardless of whether there is tumor thrombus in portal vein;

② Child-Pugh A or B liver function classification, bilirubin level ≤51.3μmol/L or reaching the standard after medical treatment;

③ The blood coagulation function is good (prothrombin activity > 40%, platelet count > 30×109/L, using sheath hemostasis and packing system);

④QECOG PS ≤2；

⑤ Cirrhosis, including a history of chronic liver disease, with widened hepatic fissure/metacentric colon/esophageal varices/gastric varices/serrated liver surface, a history of upper gastrointestinal bleeding or ascites, and platelets < 100×109/L..

In addition, Professor Yang Yongping’s team innovatively established measures to prevent and treat complications of percutaneous cryoablation of hepatocellular carcinoma. In this study, 3321 patients were selected, and the measures of percutaneous cryoablation of liver cancer complications were established and verified (Table 1).

Table 1 Measures for Complications of Percutaneous Cryoablation of Liver Cancer

Moreover, the study has achieved encouraging clinical results, which increased the complete tumor ablation rate by 10.6%, reduced the local tumor recurrence rate by 30.3% in 5 years, and improved the 5-year survival rate by 16.6%.

Advantages of cryoablation in the treatment of hepatocellular carcinoma

Although cryoablation has distinct advantages over radiofrequency ablation (RFA), there is no RCT study in the past to directly compare the efficacy of ablation of liver cancer, especially the safety. Professor Yang Yongping’s team designed RCT study in five years to evaluate the efficacy and safety of percutaneous cryoablation and radiofrequency ablation of liver cancer. For the tumor, there were statistical differences in the local tumor progression rate between the two groups at 1, 2 and 3 years: 3%, 7% and 7% in the frozen group, respectively; The RF group was 9%, 11% and 11% respectively (P = 0.043). Subgroup analysis: For hepatocellular carcinoma with a diameter of > 3cm, cryoablation has a lower local tumor progression rate (cryoablation vs. RF: 7.7% vs. 18.2%, P=0.041). There was no statistical difference in the local tumor progression rate between 1-2cm (frozen vs. RF: 0% vs.2.4%, P=1.000) and 2.1-3.0cm (frozen vs. RF: 4.1%vs.7.1%, P=0.656). The results were published in Hepatology magazine and also in China.

Professor Yang Yongping’s team also confirmed that cryoablation of HCC can produce ectopic tumor inhibition, with the incidence of ectopic tumor inhibition of 6.3%, and the median survival time of patients with ectopic tumor inhibition was significantly prolonged. The mechanism is related to the down-regulation of PD-1/PD-L1 and regulatory T cells after ablation. In addition, argon-helium cryotherapy is effective for elderly HCC.

Unresolved problems in cryoablation of HCC

There are also many problems to be solved in the process of cryoablation for HCC in the future:

1. Does tumor cell ablation release specific tumor cell death signal?

2. How can freezing produce the best ratio of necrosis and apoptosis?

3. Are the cytokines released after freezing derived from tumor microenvironment or natural immune response, and what is their time sequence?

4. Will the functional essence and time sequence of antigen presenting cells that absorb necrotic tissue change after cryoablation?

5. What is the effect of cryoablation and absorption of necrotic tissue on the immunosuppressive function of the body? How to reduce the immunosuppression of the body?

Expert introduction

Professor Yang Yongping.

Chinese people’s liberation army general hospital No.5 medical center

Director, Department of Hepatology and Medicine, PLA General Hospital

Chief physician, professor, doctoral tutor

Silver Star of Science and Technology of the General Logistics Department, winner of special allowance of the State Council

Chairman of the Professional Committee of Liver Diseases of China Research Hospital Association

Director of China Hepatitis Foundation

Director of China Research Hospital Association

Vice Chairman of Liver Disease Professional Committee of Beijing Branch of Chinese Medical Association

Vice Chairman of Liver Disease Professional Committee of Beijing Society of Integrated Traditional Chinese and Western Medicine

Take the lead in the major special topics of the "Thirteenth Five-Year Plan and Twelfth Five-Year Plan" of the country, the key topics of the "Twelfth Five-Year Plan" of the army and the key topics of the Beijing Municipal Science and Technology Commission in integration of defense and civilian technologies; Won one national science and technology progress award, one first prize of Beijing science and technology progress award and six second prizes of military science and technology progress award.

Finishing/platform review/Professor Yang Yongping

This article is only for medical and health professionals to understand information, and does not represent the views of this platform. This information cannot replace professional medical guidance in any way, nor should it be regarded as medical advice. If the information is used for purposes other than understanding the information, the platform and the author shall not bear the relevant responsibilities.

　　CCTV News:According to the WeChat official account news released by Shanghai, the Shanghai Central Meteorological Observatory issued a blue rainstorm warning signal at 12: 30 on August 23rd, 2023: Due to the influence of strong precipitation clouds, it is predicted that there will be precipitation in parts of central and southern Shanghai with a cumulative rainfall of more than 50 mm in six hours before midnight today. Please pay attention to the prevention of urban waterlogging caused by heavy rainfall, and do a good job in drainage and waterlogging prevention in low-lying and flood-prone areas.

　　The yellow warning of lightning issued before is still high.

　　Defense guide:

　　1. Stop carrying out outdoor activities in open places.

　　2. Stop swimming in rivers, lakes and seas.

　　3. Stay away from trees, corners or places with prominent metal objects; Don’t hold objects with sharp metal corners in your hands or carry them on your shoulders.

　　Defense guide:

　　1. Citizens should prepare rain gear to ensure safety.

　　2, drivers pay attention to the road water.

　　Level Ⅳ response of flood prevention platform

　　According to the introduction of the Municipal Flood Control Office, the level IV (level IV) response of the city’s flood control stations started simultaneously.

　　Level 4 (IV) emergency response (blue)

Original Zhu Xinpu Yun Dan Gongbu Zhu Xinpu Stroke Prevention Science Popularization

Sudden cardiac death (SCD) is an unpredictable natural death caused by heart, accounting for about 80% of sudden death. The main manifestations are acute onset, with more males than females. A variety of heart diseases can lead to sudden death, especially those with organic basic cardiovascular diseases or related risk factors. Patients may have a history of heart disease or heart disease in the past. At present, it is recognized that most of the deaths within one hour of onset are sudden cardiac death.

According to the China Cardiovascular Disease Report released in 2019, there are 544,000 cases of sudden cardiac death in China every year.

1. Coronary artery disease

It mainly includes coronary heart disease (coronary atherosclerotic heart disease), acute myocardial infarction, coronary thrombosis, embolism or spasm, coronary arteritis, congenital coronary artery dysplasia, etc., among which coronary heart disease is the most common.

As the most common cause of sudden death, coronary heart disease is seen in acute coronary syndrome (including acute myocardial infarction and unstable angina pectoris). According to the American Heart Association, 25% of patients with coronary heart disease take sudden cardiac death as the first clinical manifestation. According to the domestic literature, 80% of adult deaths from sudden cardiac death are related to acute coronary syndrome. These patients died of acute myocardial ischemia.

The etiological basis of coronary heart disease is atherosclerosis, which leads to the decrease of coronary blood flow and myocardial perfusion. Under the inducement, acute coronary spasm or microcirculation embolism can occur, causing acute myocardial ischemia, causing electrophysiological disorder, leading to malignant arrhythmia and even sudden cardiac death.

2.cardiomyopathy

Hypertrophic cardiomyopathy is the most common cause of sudden cardiac death in cardiomyopathy. Hypertrophic cardiomyopathy (HCM) is a complex hereditary cardiomyopathy characterized by thickening of left ventricular wall, which has various clinical and genetic manifestations. It is a common cause of sudden death in adolescents, with a high missed diagnosis rate and 50% family history.

The research shows that the risk of sudden cardiac death such as having a history of ventricular tachycardia attack, severe left ventricular wall hypertrophy (≥30mm), unexplained syncope, family history of sudden cardiac death and exercise-related hypotension is obviously increased. It is suggested that all patients with family history of sudden death should be screened by echocardiography.

3. valvular disease

Cardiac valvular disease is also one of the risk factors of sudden cardiac death, including mitral stenosis and/or insufficiency, aortic stenosis and/or insufficiency, infective endocarditis, mitral valve prolapse (MVP) or chordae tendineae rupture. For example, severe aortic stenosis can cause a serious decrease in blood flow into the aorta and cardiac output, leading to sudden cardiac death.

In China, the incidence of valvular heart disease is high, which is mainly caused by rheumatic diseases, trauma, degeneration, congenital malformation, inflammation and other reasons. The structural function of one or more valves is abnormal, resulting in stenosis and/or insufficiency of the valve orifice.

4. Structural heart disease

Structural heart disease is a general term for a large class of diseases caused by abnormal heart structure, which mainly includes: congenital heart structure abnormality, valve abnormality, coronary artery dysplasia, acquired valve disease and so on.

Congenital cardiovascular diseases mainly include atrial septal defect, ventricular septal defect, patent ductus arteriosus, coarctation of aorta, congenital aortic or pulmonary valve stenosis, tetralogy of Fallot and so on. Such diseases increase the risk of sudden cardiac death. In particular, patients with left-to-right shunt congenital heart disease who develop to Eisenmenger syndrome and complex congenital heart disease are more prone to sudden cardiac death.

Abnormal coronary artery is the main cause of sudden death in young people. Especially after strenuous exercise. The clinical manifestations are angina pectoris, arrhythmia, syncope and even sudden cardiac death after strenuous exercise. Therefore, for special people who have uncomfortable symptoms after exercise, athletes and so on, congenital coronary artery dysplasia should be screened out.

5. Aortic disease

Aortic disease is one of the important factors leading to sudden cardiac death, and its main pathogenesis is fatal ischemia of target organs caused by aortic rupture and involvement of important branches. Among them, Stanford A aortic dissection is the most dangerous, and the main causes of sudden cardiac death include: aortic rupture, pericardial tamponade, dissection involving coronary artery leading to large-scale myocardial infarction, and involvement of brachiocephalic artery leading to cerebral infarction.

6. Pulmonary embolism

Pulmonary thromboembolism is a common emergency in cardio-pulmonary vascular diseases, and its incidence and mortality are extremely high.

The embolus source of pulmonary embolism can be endogenous or exogenous, and the embolic site is mainly in the trunk or main branch of pulmonary artery. Clinically, pulmonary embolism thrombus mainly comes from venous system or right atrial appendage. When patients have pulmonary embolism, pulmonary circulation disorder can occur in a short time, and sudden cardiac death can occur in severe cases.

In daily life, sudden cardiac death caused by pulmonary embolism is most common in "economy class syndrome", that is, the lower limbs are in a state of braking for a long time, which leads to venous thrombosis. Once a large thrombus falls off, it will lead to acute pulmonary embolism, and then sudden cardiac death can occur.

In addition, a considerable number of patients’ thrombi come from the right atrial appendage, mainly due to atrial fibrillation, so for such patients, it is also necessary to be alert to the occurrence of sudden cardiac death caused by pulmonary embolism.

7. Abnormal cardiac electrophysiological activity

Abnormal primary ECG or abnormal ion channels can induce sudden cardiac death, such as sinoatrial node lesions and abnormal cardiac conduction system (Lenegre disease or Lev disease, WPW syndrome, Q-T interval extension syndrome). This is an important cause of sudden death of teenagers.

Once the cardiac electrophysiological abnormality occurs, it may induce cardiac pacing conduction disorder, eventually leading to complete atrioventricular block, and even fatal arrhythmia such as ventricular tachycardia and ventricular fibrillation may occur, which may lead to insufficient blood output from the heart to brain tissue and the whole body, resulting in shock and syncope. If cardiac arrest lasts for 5 minutes, it can cause irreversible brain tissue damage and death, which will eventually lead to sudden cardiac death.

Sometimes, viral infection and other diseases may also involve the cardiac electrical conduction system, which increases the risk of sudden death of patients.

8. Explosive myocarditis

Early mortality is extremely high, which is another important cause of sudden cardiac death in children and young adults. The early symptoms of myocarditis are very similar to the common cold, only "a little uncomfortable", which is difficult to attract attention.

9. Kawasaki disease

The etiology is not clear yet. At present, it is considered that some patients are immune-mediated systemic vasculitis triggered by various infectious pathogens (viruses, bacteria, etc.). Kawasaki disease mostly occurs in children, which is one of the main causes of sudden death of children. Having Kawasaki disease in childhood can also cause myocardial infarction in adults.

10. Others

Other causes of sudden cardiac death mainly include: acute pericardial tamponade, intracardiac thrombosis, electrolyte disorder, sleep apnea and gene correlation.

Original title: How much do you know about sudden cardiac death? 》

Read the original text

According to CCTV news, according to a report by the Japan Broadcasting Association on March 27th, local time, the Japanese Ministry of Health, Labor and Welfare announced the second death case suspected of taking a health product containing monascus from Kobayashi Pharmaceutical Company on March 26th, and the number of people admitted to the hospital has increased to 106.

Earlier, the Japanese Ministry of Health, Labor and Welfare had investigated Kobayashi Pharmaceutical Company and found that there was a new death report in addition to a previously announced death case.

Based on the Food Hygiene Law, Japan’s Ministry of Health, Labor and Welfare has asked Osaka headquarters where Kobayashi Pharmaceutical Company is located to take measures including product abandonment.

In view of the fact that many people were hospitalized and two people died after taking products containing monascus from Kobayashi Pharmaceutical Company, the Japanese Ministry of Health, Labor and Welfare will hold a meeting with the Consumer Department, the Ministry of Agriculture, Forestry and Fisheries and other relevant departments on the 27th to discuss future countermeasures.

According to Japanese media reports on the 27th, the Osaka municipal government of Japan ordered Kobayashi Pharmaceutical Company to recall three products, including "red yeast cholesterol granules".

Consumers die after taking health care products.

Kobayashi Pharmaceutical Emergency Recall

Previously, Kobayashi Pharmaceutical Co., Ltd. said that a consumer who took the company’s health care products containing monascus ingredients died of kidney disease. Some consumers suffer from diseases in kidney and other parts after using this health care product, and they are hospitalized, and some even need dialysis.

On March 26, Kobayashi Pharmaceutical updated the notice asking consumers to stop using the company’s products containing monascus ingredients and to recall them independently. According to the notice, the consumer took the company’s health care product containing monascus ingredients-monascus cholesterol granules. However, the notice did not disclose the relevant information of the consumer and the time of death.

The notice said that it has been confirmed that the consumer continued to buy red yeast cholesterol granules from April 2021 to February 2024. The company is investigating whether there is a causal relationship between the consumer’s death and taking the above health care products.

According to Kyodo News, since February 2021, monascus cholesterol granules have been sold in e-commerce channels and stores, and about 1.06 million bags have been sold by the end of February this year.

Three products involved
Are health care products for improving cholesterol.

The following is a list of three recalled products released by Kobayashi Pharmaceutical Company official website, all of which are health products for improving cholesterol. Please be careful not to buy or continue taking it.

China e-commerce platform removes products involved.

Consumers can return goods and get a refund.

Kobayashi Pharmaceutical Co., Ltd. is an old Japanese pharmaceutical company with a history of more than 100 years, and many of its products are quite popular. According to the company, monascus is a raw material produced by mixing monascus with steamed rice for fermentation. The company publicizes that this ingredient is expected to reduce the cholesterol value of low density lipoprotein.

The reporter searched a number of domestic e-commerce platforms and found that there are currently no three related products sold on the official e-commerce platform of Xiaolin Pharmaceutical, but there are still purchasing merchants selling related recalled products.

Kobayashi Pharmaceutical China Company said, "The company has received reports that it may cause kidney diseases and other problems after eating, and some of its products are sold to China through cross-border channels. If a consumer has eaten it and feels unwell, contact customer service, and the products that have not been eaten will be returned and refunded. "

On March 22nd, @ Kobayashi Pharmaceuticals issued a notice to remind consumers who have red herring cholesterol granules (60, barcode 4987072059708) to stop eating.

Up to now, the products involved have been removed from the official store of Kobayashi Pharmaceutical, the e-commerce platform mentioned in the notice. According to the reporter’s inquiry, multiple e-commerce platforms have been unable to search for this product.

Kobayashi pharmaceutical president bowed and apologized.

Admit that decision-making is slow

On the evening of March 22nd, President Kobayashi held a press conference and bowed to apologize for this issue.

According to Japanese media reports, the analysis results on the 16th of this month showed that some raw materials of monascus may contain unknown ingredients, but the company did not announce the recall until the 22nd. In this regard, the president of Kobayashi Pharmaceutical admitted that the decision was slow.

Another five Japanese companies issued a recall announcement.

Among the 18.5 tons of monascus raw materials produced by Kobayashi Pharmaceutical in 2023, about 16 tons of raw materials were sold to other companies for brewing and food manufacturing, except for their own health care products. At present, Kobayashi Pharmaceutical has issued a recall request to all 52 enterprises that purchased its monascus raw materials through its sales company. Affected by this, some food, brewing and other enterprises that use Xiaolin Pharmaceutical’s red yeast raw materials have also announced the recall of related products.

It is understood that the company is working hard to confirm the sales partners and recalls, and it is expected that the recall scale will be further expanded.

The reporter’s investigation found that at present, five Japanese companies have issued relevant recall announcements and announced related products. The names of the five enterprises are respectively Baojiuzao Co., Ltd., ZERO PLUS Co., Ltd., Doufu Co., Ltd. Nagoya Store, Takeya Co., Ltd. and Jiwen Food Co., Ltd.

Baojiuzao Co., Ltd.

On March 24th, Japan Baojiu Brewery Co., Ltd. announced that it had decided to recycle about 96,000 bottles of this product by itself because a wine produced by this company used red yeast raw materials provided by Kobayashi Pharmaceutical Company. At present, there are no reports of health damage related to this product of Baojiu Brewery Company.

According to the wine manufacturer, this wine has only been exported to Singapore and Taiwan, China, and has not entered the Chinese mainland market.

ZERO PLUS co., ltd

Japan’s ZERO PLUS Company issued a recall notice on March 22nd, saying that there may be unknown ingredients in the raw materials of red yeast in the thick cheese biscuits sold by its KUMITE brand. At present, the specific information of this ingredient cannot be determined. In order to prevent the safety problem from further expanding, it will be recycled independently from now on.

Doufu corporation company Nagoya branch

The recall announcement issued by the Nagoya Pastry Store of Doufu Co., Ltd. said that because its eight products contain red rice malt ingredients produced by Kobayashi Pharmaceutical, there are potential health risks, so they will take the initiative to recall these products and suspend sales.

Takeya corporation

On March 25th, Takeya, a Japanese miso production company, issued a notice that the product "Low-salt Monascus Miso" used the raw materials of Monascus produced by Kobayashi Pharmaceutical, and the sales of this product will be stopped from now on and recycled independently.

Jiwen food co., ltd

Japan’s Jiwen Food Company issued a notice on March 24th, stating that the products "domestic squid pickled products" and "squid pickled products" used the raw materials of red koji produced by Kobayashi Pharmaceutical, so they were recycled independently from now on. If the products are sent to the address designated by the company, the company will refund the payment in the future.

Xiaolin Pharmaceutical’s market value evaporated by over 4.2 billion yuan.

It is reported that Kobayashi Pharmaceutical (China) Co., Ltd. is a wholly-owned subsidiary of Kobayashi Pharmaceutical Co., Ltd.

According to the national enterprise credit information publicity system, Kobayashi Pharmaceutical (China) Co., Ltd. was established in Shanghai on April 9, 2018 with a registered capital of US$ 77,982,400. The legal representative is Matsushita Tuoye, and the company is 100% owned by Kobayashi Pharmaceutical Co., Ltd.

As of the morning of 27th, the share price of Kobayashi Pharmaceutical Co., Ltd. fell by 3.53%, with a total market value of 381.7 billion yen. Since the fermentation of the event, Kobayashi Pharmaceutical has fallen by nearly 20%, and its total market value has evaporated by more than 90 billion yen (about RMB 4.29 billion) compared with the closing on March 22.

Netizen: I didn’t expect health care products to be fatal.

In response to this matter, some netizens said that it was "terrible", "too scary" and "I didn’t expect health care products to be deadly", and some netizens were worried about whether other products such as warm babies and antipyretic stickers of this brand could still be used.

(Yangcheng Evening News Yangcheng School Comprehensive CCTV News, Beijing Daily, Xinhua News Agency, China News Network, Zhongxin Jingwei, Overseas Network, Beijing Youth Daily, User Comments)

Original title: Health care products are still dying? 2 deaths and 106 people have been hospitalized! Kobayashi Pharmaceutical urgently recalled, and these products should also be noted →　

　　[Bourne ultimatum] It’s another weekend in a blink of an eye, and the new issue of Bourne ultimatum meets with you. There are many heavy models in this week’s spy photos. Domestically, there are two new cars, the new RAV4, the production version, and the speed car, and the domestic L; Overseas, there are brand-new Q5, brand-new, brand-new and brand-new G-class Toyota. Next, let’s walk into the text and see the specific situation of these 9 cars.

● Zotye Damai X7

　　All along, we can find the shadow of existing models of overseas brands in many models of Zotye. However, when faced with the BMW X7, many people may be confused, but don’t rush to deny their knowledge reserves, because this car is not a production model, but a GTE. Obviously, Zotye beat us to it.

　　Damai X7 has a high degree of restoration for the appearance of Cross GTE concept car, including the front face layout and tail shape. On the side, the lines of the Damai X7 are straighter, which is not as exaggerated as the Cross Coupe GTE concept car.

　　In the interior part, Damai X7 still draws lessons from the design of the Cross Coupe GTE concept car, and even the details of the air conditioning outlet, buttons and chrome-plated decorative parts are exactly the same as the Cross Coupe GTE concept car. However, the shift lever of the manual transmission model has no sense of design, which is not very harmonious with the overall design.

　　As for the power system, Damai X7 will provide three power options, namely 1.5T, 1.8T and 2.0T. In terms of transmission system, it is matched with 5-speed manual or 6-speed.

　　Editor’s comment:Every time Zotye launches a new car, it will become the focus of consumers’ attention, because there is really no manufacturer in the market that can reverse develop overseas car companies on a large scale like Zotye. From the earliest, to the next, Zotye’s imitation road has embarked on the "first cosmic speed". What drives Zotye to go on like this is not only high attention, low research and development cost, but also good market response. For example, the monthly sales of Zotye are often above 10,000 vehicles, and in the first five months of 2016, it also sold 43,284 vehicles.

　　Although many people will show disdain for such a product, the sales data reflect that it still has a large market. This shows that Zotye’s ability to grasp consumer demand and market hotspots is still very good. This time, the concept car that Volkswagen has not yet mass-produced is used as a blueprint to imitate, and Zotye has even walked in front of the public. Since I have such a vision, I still hope Zotye can bring us more original designs, which is really ahead of other brands.

　　Read more:

　　Two Interior Styles Zotye Damai X7 Latest Real Car Map Exposure

● FAW Toyota new RAV4

　　The market has always been one of the main battlefields among the major players. Although it is an old player, the sales performance of RAV4 has no advantage over competitors. The reason is that the configuration is one aspect that many consumers are dissatisfied with, so the new RAV4 came into being, and the new car was upgraded in the configuration part, further enhancing its competitiveness.

　　The new RAV4 continues the design of overseas models in appearance. The main change lies in the front face, the air intake grille above becomes very long and narrow, and the modeling details of the front bumper below are also adjusted. At the rear, the new car redesigned the details of the taillights and bumpers.

　　In the interior, we can see that the overall design of the new car has not changed, but some models have added a 7-inch central control LCD screen and a dashboard with a 4.2-inch LCD screen. In the configuration part, automatic start-stop and body stability systems, systems and systems are added to the entry-level models. The configuration of other models has also been improved to varying degrees, which will increase functions such as panoramic image system, outdoor (with heating), keyless entry (one-button start), and uphill assistance. On the whole, the new RAV4 has a significant improvement in configuration.

"3ZR-FAE engine for overseas models"

　　In terms of power, the new RAV4 is still equipped with 2.0L and 2.5L engines, of which the 2.0L engine is a new engine code-named 3ZR-FAE, and its maximum horsepower is increased from 147 HP to 150 HP. Due to the continuous lift technology, its fuel consumption performance is worth looking forward to.

　　Editor’s comment:For consumers who are concerned about RAV4, the upgrade of this configuration should be the most attractive. The current models are not equipped with traction control and body stability control system as standard, which makes some consumers finally choose other products. The new models have been improved in these aspects, and are fully equipped with body stability system, traction control system and uphill auxiliary system, and other configurations have also been upgraded. FAW Toyota has made positive adjustments to the feedback from the market, which is very worthy of recognition.

　　In addition to the configuration, we need to pay attention to the replacement of a new 2.0L engine. Although the new engine has little improvement in power performance, according to the introduction of Toyota manufacturers, the continuous variable lift technology can reduce fuel consumption by 5-10%. For RAV4, which is biased towards home, low fuel consumption is undoubtedly an attractive selling point, which is worth looking forward to. It is expected that the price of the new car will not change much, and it may still remain in the range of 180,000-270,000 yuan.

　　Read more:

　　Or the new RAV4 configuration will be exposed on July 28th.

● Concept B production version

　　As an evergreen tree in the China brand SUV market, Haval’s every move will attract the attention of many consumers, and so will this production version of Concept B. Concept B is a production version, focusing on young and fashionable consumer groups.

　　The production version of Harvard Concept B locates a small SUV, which will be sold at the same time as H2 in the future. In terms of appearance, this car adopts a typical blue standard style, such as hexagonal air intake grille and sharp headlights, which is very similar to other blue standard models.

　　On the side, this car largely retains the design of the concept car. The waistline rises backwards, creating a running posture. At the rear, the Concept B concept car uses two exhaust ports on both sides. Referring to the car body parameters of the concept car, the length, width and height of the car body of Concept B are 4146/1772/1623mm and 2550mm respectively, which is slightly smaller.

　　The interior of the production version of Concept B is also quite individual. The center console is equipped with a large-size LCD screen, and the layout style of buttons at the bottom of the screen is the same as that of the blue standard H2. On the right side of the center console, chrome-plated decorative pieces are integrated with the air-conditioning outlets on both sides, which is very novel. In terms of configuration, the new car is equipped with functions such as reversing radar, keyless entry and one-button start. At present, the power information of the car has not been exposed.

　　Editor’s comment:In terms of body size, the production version of Haval Concept B is a small SUV between Haval H1 and H2. It is closer to the Haval H2 blue standard in terms of body size and design, and it is also likely to be equipped with a 1.5T engine in terms of power. In terms of price, the current price of Haval H1 is 54,900-82,900 yuan, and the price of Haval H2 is 88,800-12,800 yuan, of which Haval H1 focuses on the market of about 70,000 yuan, and Haval H2 focuses on the market of about 100,000-110,000 yuan. Therefore, in the market of 800,000-100,000 yuan, Harvard still has potential to be tapped, and Concept B was born for this purpose. It is estimated that the final price of this car will be around 700,000-110,000 yuan.

　　Although it is said that having more children is easy to fight, it does not mean that children will not fight. At the same time, three products are laid out in the small SUV market, which is rare in car companies. To handle the relationship between these cars well, we must do a good job in vehicle positioning, configuration level, pricing and market strategy, so that the three can be in their respective positions and form a joint force, which will be a difficult problem before Harvard. In addition, I have a question. Since this car is positioned between H1 and H2, how will it be named? Haval H1.5?

　　Read more:

　　Provide manual transmission Haval Concept B production spy photos.